PSD-95 is essential for hallucinogen and atypical antipsychotic drug actions at serotonin receptors
about
Head-twitch response in rodents induced by the hallucinogen 2,5-dimethoxy-4-iodoamphetamine: a comprehensive history, a re-evaluation of mechanisms, and its utility as a model.Predicting new molecular targets for known drugsThe role of serotonin 5-HT2A receptors in memory and cognitionIndividual Differences in Impulsive Action Reflect Variation in the Cortical Serotonin 5-HT2A Receptor SystemIn Vitro and In Vivo Characterization of the Alkaloid NuciferineDisrupting 5-HT(2A) receptor/PDZ protein interactions reduces hyperalgesia and enhances SSRI efficacy in neuropathic painRegulation of GPCR activity, trafficking and localization by GPCR-interacting proteins.Chemogenetic inactivation of ventral hippocampal glutamatergic neurons disrupts consolidation of contextual fear memory.Schizophrenia risk gene CAV1 is both pro-psychotic and required for atypical antipsychotic drug actions in vivo.The presynaptic component of the serotonergic system is required for clozapine's efficacy.HTS and rational drug design to generate a class of 5-HT(2C)-selective ligands for possible use in schizophrenia.CRF receptor 1 regulates anxiety behavior via sensitization of 5-HT2 receptor signaling.Characterization of the head-twitch response induced by hallucinogens in mice: detection of the behavior based on the dynamics of head movement.Functional status of the serotonin 5-HT2C receptor (5-HT2CR) drives interlocked phenotypes that precipitate relapse-like behaviors in cocaine dependenceNeuronal ablation of p-Akt at Ser473 leads to altered 5-HT1A/2A receptor functionSerotonin at the nexus of impulsivity and cue reactivity in cocaine addiction.Assessing serotonin receptor mRNA editing frequency by a novel ultra high-throughput sequencing method.Serotonin 5-HT2C receptor protein expression is enriched in synaptosomal and post-synaptic compartments of rat cortex.Discovery of β-arrestin-biased dopamine D2 ligands for probing signal transduction pathways essential for antipsychotic efficacy.Serotonin, but not N-methyltryptamines, activates the serotonin 2A receptor via a ß-arrestin2/Src/Akt signaling complex in vivoRapid modulation of spine morphology by the 5-HT2A serotonin receptor through kalirin-7 signaling.p90 Ribosomal S6 kinase 2, a novel GPCR kinase, is required for growth factor-mediated attenuation of GPCR signaling.A novel role for PSD-95 in mediating ethanol intoxication, drinking and place preference.Antagonist functional selectivity: 5-HT2A serotonin receptor antagonists differentially regulate 5-HT2A receptor protein level in vivo.Motor impairments, striatal degeneration, and altered dopamine-glutamate interplay in mice lacking PSD-95Quantitative analysis of glutamatergic innervation of the mouse dorsal raphe nucleus using array tomography.Progressive maturation of silent synapses governs the duration of a critical period.Serotonin-2C and -2a receptor co-expression on cells in the rat medial prefrontal cortex.5-hydroxytryptamine 2C receptors tonically augment synaptic currents in the nucleus tractus solitariiSerotonin receptor signaling and regulation via β-arrestins.Repressive epigenetic changes at the mGlu2 promoter in frontal cortex of 5-HT2A knockout mice.A Gαs DREADD mouse for selective modulation of cAMP production in striatopallidal neurons.Peptide inhibitors disrupt the serotonin 5-HT2C receptor interaction with phosphatase and tensin homolog to allosterically modulate cellular signaling and behavior.Support for 5-HT2C receptor functional selectivity in vivo utilizing structurally diverse, selective 5-HT2C receptor ligands and the 2,5-dimethoxy-4-iodoamphetamine elicited head-twitch response modelModulation of behavior by scaffolding proteins of the post-synaptic density.Striatal serotonin 2C receptors decrease nigrostriatal dopamine release by increasing GABA-A receptor tone in the substantia nigra.Review: disruption of the postsynaptic density in Alzheimer's disease and other neurodegenerative dementias.Irving Page Lecture: 5-HT(2A) serotonin receptor biology: interacting proteins, kinases and paradoxical regulation.Glycogen Synthase Kinase-3 is an Intermediate Modulator of Serotonin NeurotransmissionCalcium-dependent networks in dopamine-glutamate interaction: the role of postsynaptic scaffolding proteins.
P2860
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P2860
PSD-95 is essential for hallucinogen and atypical antipsychotic drug actions at serotonin receptors
description
2009 nî lūn-bûn
@nan
2009 թուականի Յունիսին հրատարակուած գիտական յօդուած
@hyw
2009 թվականի հունիսին հրատարակված գիտական հոդված
@hy
2009年の論文
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2009年学术文章
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2009年学术文章
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2009年学术文章
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2009年学术文章
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2009年学术文章
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2009年學術文章
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name
PSD-95 is essential for halluc ...... actions at serotonin receptors
@ast
PSD-95 is essential for halluc ...... actions at serotonin receptors
@en
type
label
PSD-95 is essential for halluc ...... actions at serotonin receptors
@ast
PSD-95 is essential for halluc ...... actions at serotonin receptors
@en
prefLabel
PSD-95 is essential for halluc ...... actions at serotonin receptors
@ast
PSD-95 is essential for halluc ...... actions at serotonin receptors
@en
P2093
P2860
P1476
PSD-95 is essential for halluc ...... actions at serotonin receptors
@en
P2093
Atheir I Abbas
Bryan L Roth
Marc G Caron
Margaret I Arbuckle
Prem N Yadav
Seth G N Grant
Wei-Dong Yao
P2860
P304
P356
10.1523/JNEUROSCI.1090-09.2009
P407
P577
2009-06-01T00:00:00Z