Electrostatic funneling of substrate in mitochondrial inner membrane carriers
about
Visualizing functional motions of membrane transporters with molecular dynamics simulationsEfficient Atomistic Simulation of Pathways and Calculation of Rate Constants for a Protein-Peptide Binding Process: Application to the MDM2 Protein and an Intrinsically Disordered p53 Peptide.Modeling and dynamics of the inward-facing state of a Na+/Cl- dependent neurotransmitter transporter homologueMitochondrial uncoupling protein 2 structure determined by NMR molecular fragment searchingStructures of yeast mitochondrial ADP/ATP carriers support a domain-based alternating-access transport mechanismThe substrate specificity of mitochondrial carriers: mutagenesis revisitedThe mechanism of transport by mitochondrial carriers based on analysis of symmetryTyrosine phosphorylation by Src within the cavity of the adenine nucleotide translocase 1 regulates ADP/ATP exchange in mitochondria.Pathway and mechanism of drug binding to G-protein-coupled receptors.Adenine nucleotide translocase is acetylated in vivo in human muscle: Modeling predicts a decreased ADP affinity and altered control of oxidative phosphorylation.Fatty acid flippase activity of UCP2 is essential for its proton transport in mitochondria.Tetrahydrofolate recognition by the mitochondrial folate transporter.Mapping conformational heterogeneity of mitochondrial nucleotide transporter in uninhibited states.The transmembrane prolines of the mitochondrial ADP/ATP carrier are involved in nucleotide binding and transport and its biogenesisSubstrate-modulated ADP/ATP-transporter dynamics revealed by NMR relaxation dispersion.A biophysical study on molecular physiology of the uncoupling proteins of the central nervous system.Channel character of uncoupling protein-mediated transportCapture and quality control mechanisms for adenosine-5'-triphosphate binding.Mutation of the mitochondrial carrier SLC25A42 causes a novel form of mitochondrial myopathy in humansMolecular dynamics simulations of membrane channels and transportersStructural basis of substrate selectivity in the glycerol-3-phosphate: phosphate antiporter GlpT.High-chloride concentrations abolish the binding of adenine nucleotides in the mitochondrial ADP/ATP carrier family.Structure and function of mitochondrial carriers - role of the transmembrane helix P and G residues in the gating and transport mechanism.Drug transport by breast cancer resistance protein.The molecular features of uncoupling protein 1 support a conventional mitochondrial carrier-like mechanismSimulation of spontaneous substrate binding revealing the binding pathway and mechanism and initial conformational response of GlpT.Homodimeric intrinsic membrane proteins. Identification and modulation of interactions between mitochondrial transporter (carrier) subunits.Capturing Functional Motions of Membrane Channels and Transporters with Molecular Dynamics Simulation.Atomistic modeling of alternating access of a mitochondrial ADP/ATP membrane transporter with molecular simulations.Mapping the nucleotide binding site of uncoupling protein 1 using atomic force microscopy.Consistent improvement of cross-docking results using binding site ensembles generated with elastic network normal modes.Conformational dynamics of the bovine mitochondrial ADP/ATP carrier isoform 1 revealed by hydrogen/deuterium exchange coupled to mass spectrometry.Formation of a cytoplasmic salt bridge network in the matrix state is a fundamental step in the transport mechanism of the mitochondrial ADP/ATP carrier.Trends in thermostability provide information on the nature of substrate, inhibitor, and lipid interactions with mitochondrial carriersModelling the free energy profile of the mitochondrial ADP/ATP carrier.Single-nucleotide evolution quantifies the importance of each site along the structure of mitochondrial carriers.The substrate specificity of the human ADP/ATP carrier AAC1.Mitochondrial ADP/ATP Carrier in Dodecylphosphocholine Binds Cardiolipins with Non-native Affinity.Dynamic Docking: A Paradigm Shift in Computational Drug Discovery.De Novo Mutations in SLC25A24 Cause a Disorder Characterized by Early Aging, Bone Dysplasia, Characteristic Face, and Early Demise.
P2860
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P2860
Electrostatic funneling of substrate in mitochondrial inner membrane carriers
description
2008 nî lūn-bûn
@nan
2008 թուականի Յուլիսին հրատարակուած գիտական յօդուած
@hyw
2008 թվականի հուլիսին հրատարակված գիտական հոդված
@hy
2008年の論文
@ja
2008年論文
@yue
2008年論文
@zh-hant
2008年論文
@zh-hk
2008年論文
@zh-mo
2008年論文
@zh-tw
2008年论文
@wuu
name
Electrostatic funneling of substrate in mitochondrial inner membrane carriers
@ast
Electrostatic funneling of substrate in mitochondrial inner membrane carriers
@en
type
label
Electrostatic funneling of substrate in mitochondrial inner membrane carriers
@ast
Electrostatic funneling of substrate in mitochondrial inner membrane carriers
@en
prefLabel
Electrostatic funneling of substrate in mitochondrial inner membrane carriers
@ast
Electrostatic funneling of substrate in mitochondrial inner membrane carriers
@en
P2860
P356
P1476
Electrostatic funneling of substrate in mitochondrial inner membrane carriers
@en
P2093
P2860
P304
P356
10.1073/PNAS.0801786105
P407
P577
2008-07-08T00:00:00Z