Orai1 and STIM1 move to the immunological synapse and are up-regulated during T cell activation. - Wikidata - wikimedia - TriplyDB

Orai1 and STIM1 move to the immunological synapse and are up-regulated during T cell activation.

Orai1 and STIM1 move to the immunological synapse and are up-regulated during T cell activation.

http://www.wikidata.org/entity/Q30483548

about

Localization of Kv1.3 channels in the immunological synapse modulates the calcium response to antigen stimulation in T lymphocytes Junctate is a Ca2+-sensing structural component of Orai1 and stromal interaction molecule 1 (STIM1)Human muscle economy myoblast differentiation and excitation-contraction coupling use the same molecular partners, STIM1 and STIM2 The STIM1/Orai signaling machinery Molecular regulation of CRAC channels and their role in lymphocyte function The naturally processed CD95L elicits a c-yes/calcium/PI3K-driven cell migration pathway Junctophilin-4, a component of the endoplasmic reticulum-plasma membrane junctions, regulates Ca2+ dynamics in T cells Dynamic movement of the calcium sensor STIM1 and the calcium channel Orai1 in activated T-cells: puncta and distal caps.STIMulating store-operated Ca(2+) entry.Adhesion shapes T cells for prompt and sustained T-cell receptor signalling.Migrational guidance of neutrophils is mechanotransduced via high-affinity LFA-1 and calcium flux Orai1 function is essential for T cell homing to lymph nodes Morphological change of CD4(+) T cell during contact with DC modulates T-cell activation by accumulation of F-actin in the immunology synapse A large Rab GTPase encoded by CRACR2A is a component of subsynaptic vesicles that transmit T cell activation signals.Orai1 regulates intracellular calcium, arrest, and shape polarization during neutrophil recruitment in shear flow.Differential calcium signaling and Kv1.3 trafficking to the immunological synapse in systemic lupus erythematosus Molecular basis of calcium signaling in lymphocytes: STIM and ORAI The immunological synapse: a dynamic platform for local signaling.Calcium signaling in immune cells.Sequential Steps of CRAC Channel Activation.Endothelial and smooth muscle cell ion channels in pulmonary vasoconstriction and vascular remodeling Pannexin-1 hemichannel-mediated ATP release together with P2X1 and P2X4 receptors regulate T-cell activation at the immune synapse.STIM proteins and the endoplasmic reticulum-plasma membrane junctions.Differential STIM1 expression in T and B cell subsets suggests a role in determining antigen receptor signal amplitude Real-time in vivo analysis of T cell activation in the central nervous system using a genetically encoded calcium indicator.Stromal interaction molecule 1 (STIM1) and Orai1 mediate histamine-evoked calcium entry and nuclear factor of activated T-cells (NFAT) signaling in human umbilical vein endothelial cells.KCa3.1 and TRPM7 channels at the uropod regulate migration of activated human T cells.Store-operated Ca²+ signaling in dendritic cells occurs independently of STIM1 Polarized but differential localization and recruitment of STIM1, Orai1 and TRPC channels in secretory cells.Nuclear calcium is required for human T cell activation.TRPM7 regulates quiescent/proliferative metabolic transitions in lymphocytes.The Orai-1 and STIM-1 complex controls human dendritic cell maturation Calcium signaling in lymphocytes Formation of STIM and Orai complexes: puncta and distal caps.Itk: the rheostat of the T cell response.STIM and Orai: the long-awaited constituents of store-operated calcium entry Activity and Ca²⁺ regulate the mobility of TRPV1 channels in the plasma membrane of sensory neurons.Immune synapse: conductor of orchestrated organelle movement.ORAI1 deficiency impairs activated T cell death and enhances T cell survival A truncation variant of the cation channel P2RX5 is upregulated during T cell activation.

P2860

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P2860

Orai1 and STIM1 move to the immunological synapse and are up-regulated during T cell activation.

http://www.wikidata.org/entity/Q30483548

description

2008 nî lūn-bûn

@nan

2008 թուականի Փետրուարին հրատարակուած գիտական յօդուած

@hyw

2008 թվականի փետրվարին հրատարակված գիտական հոդված

@hy

2008年の論文

@ja

2008年論文

@yue

2008年論文

@zh-hant

2008年論文

@zh-hk

2008年論文

@zh-mo

2008年論文

@zh-tw

2008年论文

@wuu

name

Orai1 and STIM1 move to the im ...... ated during T cell activation.

@ast

Orai1 and STIM1 move to the im ...... ated during T cell activation.

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type

label

Orai1 and STIM1 move to the im ...... ated during T cell activation.

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Orai1 and STIM1 move to the im ...... ated during T cell activation.

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prefLabel

Orai1 and STIM1 move to the im ...... ated during T cell activation.

@ast

Orai1 and STIM1 move to the im ...... ated during T cell activation.

@en

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P356

PNAS.0706122105

P1433

Proceedings of the National Academy of Sciences of the United States of America

P1476

Orai1 and STIM1 move to the im ...... lated during T cell activation

@en

P2093

J Ashot Kozak

http://www.w3.org/2001/XMLSchema#string

Jack Roos

http://www.w3.org/2001/XMLSchema#string

Kenneth A Stauderman

http://www.w3.org/2001/XMLSchema#string

Maria I Lioudyno

http://www.w3.org/2001/XMLSchema#string

Michael D Cahalan

http://www.w3.org/2001/XMLSchema#string

Olga Safrina

http://www.w3.org/2001/XMLSchema#string

Shenyuan L Zhang

http://www.w3.org/2001/XMLSchema#string

P2860

Orai1 is an essential pore subunit of the CRAC channel

STIM is a Ca2+ sensor essential for Ca2+-store-depletion-triggered Ca2+ influx

STIM1 is a Ca2+ sensor that activates CRAC channels and migrates from the Ca2+ store to the plasma membrane

Genome-wide RNAi screen of Ca(2+) influx identifies genes that regulate Ca(2+) release-activated Ca(2+) channel activity

Kv1.3 potassium channels are localized in the immunological synapse formed between cytotoxic and target cells

K+ channels as targets for specific immunomodulation

Kv1.3 channels are a therapeutic target for T cell-mediated autoimmune diseases

STIM1, an essential and conserved component of store-operated Ca2+ channel function

Molecular identification of the CRAC channel by altered ion selectivity in a mutant of Orai

Three-dimensional segregation of supramolecular activation clusters in T cells

P304

2011-2016

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scholarly article

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10.1073/PNAS.0706122105

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6

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105

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2008-02-04T00:00:00Z

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5602701

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18250319

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2538873

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