Total synthesis and evaluation of cytostatin, its C10-C11 diastereomers, and additional key analogues: impact on PP2A inhibition

Total synthesis and evaluation of cytostatin, its C10-C11 diastereomers, and additional key analogues: impact on PP2A inhibition

Item
http://www.wikidata.org/entity/Q30484031
Suppression of Ser/Thr phosphatase 4 (PP4C/PPP4C) mimics a novel post-mitotic action of fostriecin, producing mitotic slippage followed by tetraploid cell deathTotal synthesis, assignment of the relative and absolute stereochemistry, and structural reassignment of phostriecin (aka Sultriecin)Total synthesis of fostriecin: via a regio- and stereoselective polyene hydration, oxidation, and hydroboration sequenceTotal synthesis and evaluation of phostriecin and key structural analoguesEnantioselective hydroformylation of N-vinyl carboxamides, allyl carbamates, and allyl ethers using chiral diazaphospholane ligands.A Highly Convergent Total Synthesis of Leustroducsin Bcis-Delta(2,3)-double bond of phoslactomycins is generated by a post-PKS tailoring enzyme.Structure-activity relationship studies of fostriecin, cytostatin, and key analogs, with PP1, PP2A, PP5, and( beta12-beta13)-chimeras (PP1/PP2A and PP5/PP2A), provide further insight into the inhibitory actions of fostriecin family inhibitorsThe phosphoprotein phosphatase family of Ser/Thr phosphatases as principal targets of naturally occurring toxins.De novo synthesis of natural products via the asymmetric hydration of polyenes.Synthetic Strategies Employed for the Construction of Fostriecin and Related Natural Products.Natural product analogues: towards a blueprint for analogue-focused synthesis.The Difference a Single Atom Can Make: Synthesis and Design at the Chemistry-Biology Interface.Formation of α-chiral centers by asymmetric β-C(sp3)-H arylation, alkenylation, and alkynylation.
P2860

Total synthesis and evaluation of cytostatin, its C10-C11 diastereomers, and additional key analogues: impact on PP2A inhibition

Item
http://www.wikidata.org/entity/Q30484031
description
2006 nî lūn-bûn
@nan
2006 թուականի Դեկտեմբերին հրատարակուած գիտական յօդուած
@hyw
2006 թվականի դեկտեմբերին հրատարակված գիտական հոդված
@hy
2006年の論文
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2006年論文
@yue
2006年論文
@zh-hant
2006年論文
@zh-hk
2006年論文
@zh-mo
2006年論文
@zh-tw
2006年论文
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name
Total synthesis and evaluation ...... ues: impact on PP2A inhibition
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Total synthesis and evaluation ...... ues: impact on PP2A inhibition
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type
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Total synthesis and evaluation ...... ues: impact on PP2A inhibition
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Total synthesis and evaluation ...... ues: impact on PP2A inhibition
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Total synthesis and evaluation ...... ues: impact on PP2A inhibition
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Total synthesis and evaluation ...... ues: impact on PP2A inhibition
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P2093
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P5875
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Total synthesis and evaluation ...... ues: impact on PP2A inhibition
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P2093
P2860
P304
P31
P356
P407
P433
P478
P577
P5875
P698
P932