Genome-wide association analysis reveals a SOD1 mutation in canine degenerative myelopathy that resembles amyotrophic lateral sclerosis. - Wikidata - wikimedia - TriplyDB

Genome-wide association analysis reveals a SOD1 mutation in canine degenerative myelopathy that resembles amyotrophic lateral sclerosis.

Genome-wide association analysis reveals a SOD1 mutation in canine degenerative myelopathy that resembles amyotrophic lateral sclerosis.

http://www.wikidata.org/entity/Q30485762

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The domestic dog: man's best friend in the genomic era A retrospective study of the prevalence of the canine degenerative myelopathy associated superoxide dismutase 1 mutation (SOD1:c.118G > A) in a referral population of German Shepherd dogs from the UK Cell-based therapy for neural disorders--anticipating challenges From animal models to human disease: a genetic approach for personalized medicine in ALS DNA testing in neurologic diseases Array-based whole-genome survey of dog saliva DNA yields high quality SNP data Cu,Zn-superoxide dismutase is required for cell wall structure and for tolerance to cell wall-perturbing agents in Saccharomyces cerevisiae.A contracted DNA repeat in LHX3 intron 5 is associated with aberrant splicing and pituitary dwarfism in German shepherd dogs Genetic and phenotypic variations of inherited retinal diseases in dogs: the power of within- and across-breed studies Man's best friend becomes biology's best in show: genome analyses in the domestic dog Localization of canine brachycephaly using an across breed mapping approach.From caveman companion to medical innovator: genomic insights into the origin and evolution of domestic dogs.Differential genetic regulation of canine hip dysplasia and osteoarthritis.A role for copper in the toxicity of zinc-deficient superoxide dismutase to motor neurons in amyotrophic lateral sclerosis Upregulation of CB2 receptors in reactive astrocytes in canine degenerative myelopathy, a disease model of amyotrophic lateral sclerosis.A transcription factor map as revealed by a genome-wide gene expression analysis of whole-blood mRNA transcriptome in multiple sclerosis.Leading the way: canine models of genomics and disease Characterization of thoracic motor and sensory neurons and spinal nerve roots in canine degenerative myelopathy, a potential disease model of amyotrophic lateral sclerosis.Characterization of intercostal muscle pathology in canine degenerative myelopathy: a disease model for amyotrophic lateral sclerosis.LGI2 truncation causes a remitting focal epilepsy in dogs.Mechanisms, models and biomarkers in amyotrophic lateral sclerosis Aggregation propensities of superoxide dismutase G93 hotspot mutants mirror ALS clinical phenotypes Progress of genome wide association study in domestic animals The domestic cat as a large animal model for characterization of disease and therapeutic intervention in hereditary retinal blindness.The prevalence of nine genetic disorders in a dog population from Belgium, the Netherlands and Germany.Breed-specific hematological phenotypes in the dog: a natural resource for the genetic dissection of hematological parameters in a mammalian species Model systems of motor neuron diseases as a platform for studying pathogenic mechanisms and searching for therapeutic agents.DNA testing and domestic dogs Th17 Pathway As a Target for Multipotent Stromal Cell Therapy in Dogs: Implications for Translational Research.Genome-wide association studies for multiple diseases of the German Shepherd Dog.Genomic analyses of modern dog breeds Variants within the SP110 nuclear body protein modify risk of canine degenerative myelopathy.IQCB1 and PDE6B mutations cause similar early onset retinal degenerations in two closely related terrier dog breeds Variation in aggregation propensities among ALS-associated variants of SOD1: correlation to human disease.Changes in respiratory function in Pembroke Welsh Corgi dogs with degenerative myelopathy.Adeno-associated virus serotypes 9 and rh10 mediate strong neuronal transduction of the dog brain.Degenerative myelopathy in the Collie breed: a retrospective immunohistochemical analysis of superoxide dismutase 1 in an affected Rough Collie, and a molecular epidemiological survey of the SOD1: c.118G>A mutation in Japan.Cerebrospinal Fluid Levels of Phosphorylated Neurofilament Heavy as a Diagnostic Marker of Canine Degenerative Myelopathy.SOD1 and TDP-43 animal models of amyotrophic lateral sclerosis: recent advances in understanding disease toward the development of clinical treatments.Intervertebral disk degeneration in dogs: consequences, diagnosis, treatment, and future directions.

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P2860

Genome-wide association analysis reveals a SOD1 mutation in canine degenerative myelopathy that resembles amyotrophic lateral sclerosis.

http://www.wikidata.org/entity/Q30485762

description

2009 nî lūn-bûn

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2009 թուականի Փետրուարին հրատարակուած գիտական յօդուած

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2009 թվականի փետրվարին հրատարակված գիտական հոդված

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2009年の論文

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2009年論文

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2009年論文

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2009年論文

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2009年論文

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2009年論文

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2009年论文

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Genome-wide association analys ...... amyotrophic lateral sclerosis.

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Genome-wide association analys ...... amyotrophic lateral sclerosis.

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Genome-wide association analys ...... amyotrophic lateral sclerosis.

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Genome-wide association analys ...... amyotrophic lateral sclerosis.

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Proceedings of the National Academy of Sciences of the United States of America

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Genome-wide association analys ...... amyotrophic lateral sclerosis.

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Dennis P O'Brien

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G Diane Shelton

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Gary S Johnson

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Gayle C Johnson

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Izabella Baranowska

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Jeremy F Taylor

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Joan R Coates

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Martin L Katz

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Michele Perloski

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Natasha J Olby

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P2860

Aggregation and Motor Neuron Toxicity of an ALS-Linked SOD1 Mutant Independent from Wild-Type SOD1

PLINK: a tool set for whole-genome association and population-based linkage analyses

Amyotrophic lateral sclerosis and structural defects in Cu,Zn superoxide dismutase

Haploview: analysis and visualization of LD and haplotype maps

Mutations in Cu/Zn superoxide dismutase gene are associated with familial amyotrophic lateral sclerosis

Motor neurons in Cu/Zn superoxide dismutase-deficient mice develop normally but exhibit enhanced cell death after axonal injury

Motor neuron degeneration in mice that express a human Cu,Zn superoxide dismutase mutation

ALS: a disease of motor neurons and their nonneuronal neighbors

Function of the Greek key connection analysed using circular permutants of superoxide dismutase.

Homozygosity for Asn86Ser mutation in the CuZn-superoxide dismutase gene produces a severe clinical phenotype in a juvenile onset case of familial amyotrophic lateral sclerosis.

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