Opa1-mediated cristae opening is Bax/Bak and BH3 dependent, required for apoptosis, and independent of Bak oligomerization. - Wikidata - wikimedia - TriplyDB

Opa1-mediated cristae opening is Bax/Bak and BH3 dependent, required for apoptosis, and independent of Bak oligomerization.

Opa1-mediated cristae opening is Bax/Bak and BH3 dependent, required for apoptosis, and independent of Bak oligomerization.

http://www.wikidata.org/entity/Q30485835

about

The effect of OPA1 on mitochondrial Ca²⁺ signaling Bcl-2 family interaction with the mitochondrial morphogenesis machinery ChChd3, an inner mitochondrial membrane protein, is essential for maintaining crista integrity and mitochondrial function The BH3-only Bnip3 binds to the dynamin Opa1 to promote mitochondrial fragmentation and apoptosis by distinct mechanisms Bcl-xL phosphorylation at Ser49 by polo kinase 3 during cell cycle progression and checkpoints Endophilin B1/Bif-1 stimulates BAX activation independently from its capacity to produce large scale membrane morphological rearrangements Regulation of the intrinsic apoptosis pathway by reactive oxygen species Alterations of mitochondrial dynamics allow retrograde propagation of locally initiated axonal insults Mito-priming as a method to engineer Bcl-2 addiction.BH3 peptides induce mitochondrial fission and cell death independent of BAX/BAK Putting the pieces together: How is the mitochondrial pathway of apoptosis regulated in cancer and chemotherapy?Multifaceted role of prohibitin in cell survival and apoptosis The i-AAA protease YME1L and OMA1 cleave OPA1 to balance mitochondrial fusion and fission OPA1-dependent cristae modulation is essential for cellular adaptation to metabolic demand The OPA1-dependent mitochondrial cristae remodeling pathway controls atrophic, apoptotic, and ischemic tissue damage A novel prohibitin-binding compound induces the mitochondrial apoptotic pathway through NOXA and BIM upregulation Neuronal hypoxia disrupts mitochondrial fusion Specific interaction with cardiolipin triggers functional activation of Dynamin-Related Protein 1 Bcl-xL-mediated remodeling of rod and cone synaptic mitochondria after postnatal lead exposure: electron microscopy, tomography and oxygen consumption Release of mitochondrial Opa1 following oxidative stress in HT22 cells Efficient elimination of cancer cells by deoxyglucose-ABT-263/737 combination therapy Bax activation initiates the assembly of a multimeric catalyst that facilitates Bax pore formation in mitochondrial outer membranes New insights into mitochondrial structure during cell death.The micro-architecture of mitochondria at active zones: electron tomography reveals novel anchoring scaffolds and cristae structured for high-rate metabolism Loss of OPA1 disturbs cellular calcium homeostasis and sensitizes for excitotoxicity.Cholesterol and peroxidized cardiolipin in mitochondrial membrane properties, permeabilization and cell death Targeting bioenergetics to enhance cancer chemotherapy: mitochondria SLP into apoptosis.Mitochondria and apoptosis: a quick take on a long view.Mitochondrial shape changes: orchestrating cell pathophysiology.Elucidating cytochrome C release from mitochondria: insights from an in silico three-dimensional model Activation of mitochondrial protease OMA1 by Bax and Bak promotes cytochrome c release during apoptosis.Mitochondrial fission and cristae disruption increase the response of cell models of Huntington's disease to apoptotic stimuli.Modulation of mitochondrial function and morphology by interaction of Omi/HtrA2 with the mitochondrial fusion factor OPA1.APOOL is a cardiolipin-binding constituent of the Mitofilin/MINOS protein complex determining cristae morphology in mammalian mitochondria.Mitochondrial configurations in peripheral nerve suggest differential ATP production.Deregulation of mitochondria-shaping proteins Opa-1 and Drp-1 in manganese-induced apoptosis Mitochondria in apoptosis: Bcl-2 family members and mitochondrial dynamics.Mitochondrial and metabolic dysfunction in renal convoluted tubules of obese mice: protective role of melatonin.Resolving presynaptic structure by electron tomography The BCL-2 family reunion.

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P2860

Opa1-mediated cristae opening is Bax/Bak and BH3 dependent, required for apoptosis, and independent of Bak oligomerization.

http://www.wikidata.org/entity/Q30485835

description

2008 nî lūn-bûn

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2008 թուականի Օգոստոսին հրատարակուած գիտական յօդուած

@hyw

2008 թվականի օգոստոսին հրատարակված գիտական հոդված

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2008年の論文

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2008年論文

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2008年論文

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2008年論文

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2008年論文

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2008年論文

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2008年论文

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Opa1-mediated cristae opening ...... endent of Bak oligomerization.

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Opa1-mediated cristae opening ...... endent of Bak oligomerization.

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Opa1-mediated cristae opening ...... endent of Bak oligomerization.

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J.MOLCEL.2008.07.010

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Opa1-mediated cristae opening ...... endent of Bak oligomerization.

@en

P2093

Amruta Dixit

http://www.w3.org/2001/XMLSchema#string

Donald D Newmeyer

http://www.w3.org/2001/XMLSchema#string

Guy Perkins

http://www.w3.org/2001/XMLSchema#string

Lydia Lartigue

http://www.w3.org/2001/XMLSchema#string

Mark H Ellisman

http://www.w3.org/2001/XMLSchema#string

Ray T Scott

http://www.w3.org/2001/XMLSchema#string

Ryuji Yamaguchi

http://www.w3.org/2001/XMLSchema#string

Tomomi Kuwana

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Yulia Kushnareva

http://www.w3.org/2001/XMLSchema#string

P2860

Primary structure of a dynamin-related mouse mitochondrial GTPase and its distribution in brain, subcellular localization, and effect on mitochondrial morphology

Oligomeric Bax is a component of the putative cytochrome c release channel MAC, mitochondrial apoptosis-induced channel

The mitochondrial inner membrane protein mitofilin controls cristae morphology

Roles of the mammalian mitochondrial fission and fusion mediators Fis1, Drp1, and Opa1 in apoptosis

OPA1 controls apoptotic cristae remodeling independently from mitochondrial fusion

Mitochondrial rhomboid PARL regulates cytochrome c release during apoptosis via OPA1-dependent cristae remodeling

Bid, Bax, and lipids cooperate to form supramolecular openings in the outer mitochondrial membrane

The release of cytochrome c from mitochondria: a primary site for Bcl-2 regulation of apoptosis

A distinct pathway remodels mitochondrial cristae and mobilizes cytochrome c during apoptosis

Different mitochondrial intermembrane space proteins are released during apoptosis in a manner that is coordinately initiated but can vary in duration.

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10.1016/J.MOLCEL.2008.07.010

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4

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31

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2008-08-07T00:00:00Z

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23160602

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18691924

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2636708

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