Mechanisms contributing to synaptic Ca2+ signals and their heterogeneity in hair cells
about
A 'calcium capacitor' shapes cholinergic inhibition of cochlear hair cellsRab3-interacting molecules 2α and 2β promote the abundance of voltage-gated CaV1.3 Ca2+ channels at hair cell active zonesThe Ca2+ channel subunit beta2 regulates Ca2+ channel abundance and function in inner hair cells and is required for hearingNew insights into cochlear sound encodingHair cells use active zones with different voltage dependence of Ca2+ influx to decompose sounds into complementary neural codes.Synaptopathy in the noise-exposed and aging cochlea: Primary neural degeneration in acquired sensorineural hearing loss.Cochlear hair cells: The sound-sensing machines.Phase-locking precision is enhanced by multiquantal release at an auditory hair cell ribbon synapse.Relating structure and function of inner hair cell ribbon synapses.Developmental refinement of hair cell synapses tightens the coupling of Ca2+ influx to exocytosis.Fine Tuning of CaV1.3 Ca2+ channel properties in adult inner hair cells positioned in the most sensitive region of the Gerbil CochleaTransmitter release from cochlear hair cells is phase locked to cyclic stimuli of different intensities and frequencies.Opposing gradients of ribbon size and AMPA receptor expression underlie sensitivity differences among cochlear-nerve/hair-cell synapsesThe diverse roles of ribbon synapses in sensory neurotransmission.Functional properties of synaptic transmission in primary sense organsTwo modes of release shape the postsynaptic response at the inner hair cell ribbon synapseBassoon and the synaptic ribbon organize Ca²+ channels and vesicles to add release sites and promote refillingLocation of release sites and calcium-activated chloride channels relative to calcium channels at the photoreceptor ribbon synapse.Burst activity and ultrafast activation kinetics of CaV1.3 Ca²⁺ channels support presynaptic activity in adult gerbil hair cell ribbon synapses.Calcium regulates molecular interactions of otoferlin with soluble NSF attachment protein receptor (SNARE) proteins required for hair cell exocytosis.EF-hand protein Ca2+ buffers regulate Ca2+ influx and exocytosis in sensory hair cellsA new probe for super-resolution imaging of membranes elucidates trafficking pathwaysSpecialized postsynaptic morphology enhances neurotransmitter dilution and high-frequency signaling at an auditory synapseAre unreliable release mechanisms conserved from NMJ to CNS?Development of new peptide-based tools for studying synaptic ribbon functionAdvances in imaging ultrastructure yield new insights into presynaptic biologyReduced endogenous Ca2+ buffering speeds active zone Ca2+ signalingRelease probability of hippocampal glutamatergic terminals scales with the size of the active zone.Presynaptic localization of GluK5 in rod photoreceptors suggests a novel function of high affinity glutamate receptors in the mammalian retina.Unfolding mechanism of thrombin-binding aptamer revealed by molecular dynamics simulation and Markov State Model.Presynaptic CaV1.3 channels regulate synaptic ribbon size and are required for synaptic maintenance in sensory hair cells.Response properties from turtle auditory hair cell afferent fibers suggest spike generation is driven by synchronized release both between and within synapses.Maturation of active zone assembly by Drosophila BruchpilotPresynaptic [Ca(2+)] and GCAPs: aspects on the structure and function of photoreceptor ribbon synapses.Global Ca2+ signaling drives ribbon-independent synaptic transmission at rod bipolar cell synapses.Structure and development of cochlear afferent innervation in mammals.EF hand-mediated Ca- and cGMP-signaling in photoreceptor synaptic terminals.Neural circuit development in the mammalian cochlea.New developments in understanding the mechanisms and function of spontaneous electrical activity in the developing mammalian auditory system.Role of intracellular calcium stores in hair-cell ribbon synapse.
P2860
Q26830727-21F39187-8BBA-47DC-BC57-AC50545A376EQ27326298-FB16FE4B-6FCE-4AC3-9BA7-A85AAD53F90FQ27347987-F592A6F0-3D03-45E0-BF69-C379E7C7C569Q28068730-E1AB583E-33A1-44FD-B491-AE9C2B6C8ECBQ30363786-6F93AAD1-D143-4A67-BF65-DA980854A423Q30368644-31796F98-3FCE-4DEA-BAF9-BB0B02E8A4B0Q30370018-674AEDE2-04EB-4A34-82E3-EA6DD49101B5Q30402776-851CA7BE-BE70-48B0-8DFD-3C7B69698509Q30407369-1D55ED24-16FF-4F27-92DF-FC3421C005B0Q30419502-5C393D29-106C-456C-B013-3BEACBE66D3DQ30425542-2B655933-BE18-4980-B2A8-1A78D67B6DFAQ30452490-0A0199AD-198B-4CC0-A0C4-18A32476B895Q30470171-A51599D7-1CB9-4922-93CA-7EE2C6C20CB5Q30475345-6185A46E-0140-4903-ABDE-D3A209C22BF7Q30482047-CF2E337B-E5DB-4979-B437-92C35A8CFAF0Q30494256-ED50B03B-BBB7-473B-BCF4-5BB6F0E19580Q30497701-27D48E12-C890-4380-B34E-F0343FF704B9Q30497941-1830089D-FB4E-4ED2-9CB9-5D0B552CFF9EQ30544155-DA5E8D3C-FE9E-48EF-B291-F748A0BA414DQ30575681-EA1E45B7-8528-41CC-965A-63EF75BE89D8Q30625597-13ED8C4A-55B0-4C21-B6A7-2E5CF53983BCQ33663162-65A4C276-A634-4E53-B3E6-8C53A84395BEQ33735553-44A18F47-B52C-4195-A5D9-602B8D1349D2Q33827714-E6FE45EC-EFAB-4BA1-A266-2AB88BAD5B14Q35160455-74C32CED-7F57-45A4-AFEB-5866FFC58BDBQ35635007-BE6A175F-3A9C-4AA0-B97D-ACABBE445D2FQ35740458-69235DA9-0D25-48A6-BFA8-2645C6CD6CDDQ36068532-1C400397-513E-4878-B3C7-11FA6CD40137Q36290014-505FEDC6-3BAD-4B29-8C6B-B54500326578Q36764871-025FA6FF-4AE4-4F35-8CB0-0B5CB98FC03CQ37032158-63CA4874-D91A-436F-840B-B083BB5ACD99Q37054747-0CDA1EC9-9FA6-4C36-8CCD-B8B826FCE5F4Q37267704-31F26A9E-E6F5-4021-847E-DB06F34A64E1Q37559115-39E2EFC9-CE67-46CB-A30D-4100F7E08EF5Q37732638-932D0847-5251-4BF4-8FAE-513E6E5D6A14Q37900809-6A53A24A-FC5D-4943-B11B-48E3D9442954Q37990913-2A0BD807-925E-418F-B73E-5169AF9892D4Q38002837-7DEDAB77-9B0B-441E-A722-5A362EB5753DQ38004829-8F316E8E-C860-4E85-B30A-06FAB9AA385DQ38223753-315EAD11-2E0A-4315-86FF-CF007887C9E6
P2860
Mechanisms contributing to synaptic Ca2+ signals and their heterogeneity in hair cells
description
2009 nî lūn-bûn
@nan
2009 թուականի Փետրուարին հրատարակուած գիտական յօդուած
@hyw
2009 թվականի փետրվարին հրատարակված գիտական հոդված
@hy
2009年の論文
@ja
2009年論文
@yue
2009年論文
@zh-hant
2009年論文
@zh-hk
2009年論文
@zh-mo
2009年論文
@zh-tw
2009年论文
@wuu
name
Mechanisms contributing to synaptic Ca2+ signals and their heterogeneity in hair cells
@ast
Mechanisms contributing to synaptic Ca2+ signals and their heterogeneity in hair cells
@en
type
label
Mechanisms contributing to synaptic Ca2+ signals and their heterogeneity in hair cells
@ast
Mechanisms contributing to synaptic Ca2+ signals and their heterogeneity in hair cells
@en
prefLabel
Mechanisms contributing to synaptic Ca2+ signals and their heterogeneity in hair cells
@ast
Mechanisms contributing to synaptic Ca2+ signals and their heterogeneity in hair cells
@en
P2860
P356
P1476
Mechanisms contributing to synaptic Ca2+ signals and their heterogeneity in hair cells
@en
P2093
Andreas Neef
Darina Khimich
P2860
P304
P356
10.1073/PNAS.0813213106
P407
P577
2009-02-25T00:00:00Z