Identification and characterization of a small molecule inhibitor of formin-mediated actin assembly. - Wikidata - wikimedia - TriplyDB

Identification and characterization of a small molecule inhibitor of formin-mediated actin assembly.

Identification and characterization of a small molecule inhibitor of formin-mediated actin assembly.

http://www.wikidata.org/entity/Q30491999

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L-plastin nanobodies perturb matrix degradation, podosome formation, stability and lifetime in THP-1 macrophages Actin cytoskeleton in myofibroblast differentiation: ultrastructure defining form and driving function Mechanical confinement triggers glioma linear migration dependent on formin FHOD3.Cordon bleu promotes the assembly of brush border microvilli.Integration of linear and dendritic actin nucleation in Nck-induced actin comets.Small-molecule agonists of mammalian Diaphanous-related (mDia) formins reveal an effective glioblastoma anti-invasion strategy.A dynamic formin-dependent deep F-actin network in axons.α5β1 integrin recycling promotes Arp2/3-independent cancer cell invasion via the formin FHOD3.Endothelial Cells Use a Formin-Dependent Phagocytosis-Like Process to Internalize the Bacterium Listeria monocytogenes The RhoGEF TEM4 Regulates Endothelial Cell Migration by Suppressing Actomyosin Contractility Profilin-1 serves as a gatekeeper for actin assembly by Arp2/3-dependent and -independent pathways.Actin recruitment to the Chlamydia inclusion is spatiotemporally regulated by a mechanism that requires host and bacterial factors Functional hierarchy of redundant actin assembly factors revealed by fine-grained registration of intrinsic image fluctuations.Arp2/3 inhibition induces amoeboid-like protrusions in MCF10A epithelial cells by reduced cytoskeletal-membrane coupling and focal adhesion assembly Actin kinetics shapes cortical network structure and mechanics.Identification of an ATP-controlled allosteric switch that controls actin filament nucleation by Arp2/3 complex.Structural Characterization and Computer-Aided Optimization of a Small-Molecule Inhibitor of the Arp2/3 Complex, a Key Regulator of the Actin Cytoskeleton Cdk1-dependent mitotic enrichment of cortical myosin II promotes cell rounding against confinement Integrin-matrix clusters form podosome-like adhesions in the absence of traction forces The antagonistic modulation of Arp2/3 activity by N-WASP, WAVE2 and PICK1 defines dynamic changes in astrocyte morphology Proteasomal degradation of Nck1 but not Nck2 regulates RhoA activation and actin dynamics α-Actinin-4/FSGS1 is required for Arp2/3-dependent actin assembly at the adherens junction Small molecules discovered in a pathway screen target the Rho pathway in cytokinesis.Contractility of the cell rear drives invasion of breast tumor cells in 3D Matrigel.Rac1 drives melanoblast organization during mouse development by orchestrating pseudopod- driven motility and cell-cycle progression.Analysis of turnover dynamics of the submembranous actin cortex Analysis of the local organization and dynamics of cellular actin networks Mechanisms of leading edge protrusion in interstitial migration.Formation of adherens junctions leads to the emergence of a tissue-level tension in epithelial monolayers.An optogenetic tool for the activation of endogenous diaphanous-related formins induces thickening of stress fibers without an increase in contractility A mechanism of leading-edge protrusion in the absence of Arp2/3 complex.Open source software for quantification of cell migration, protrusions, and fluorescence intensities.Profilin connects actin assembly with microtubule dynamics.Formin-mediated actin polymerization at cell-cell junctions stabilizes E-cadherin and maintains monolayer integrity during wound repair.Exosomes surf on filopodia to enter cells at endocytic hot spots, traffic within endosomes, and are targeted to the ER Role for formin-like 1-dependent acto-myosin assembly in lipid droplet dynamics and lipid storage.SMIFH2 has effects on Formins and p53 that perturb the cell cytoskeleton Actin is required for IFT regulation in Chlamydomonas reinhardtii Tension is required but not sufficient for focal adhesion maturation without a stress fiber template Loss of γ-cytoplasmic actin triggers myofibroblast transition of human epithelial cells.

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P2860

Identification and characterization of a small molecule inhibitor of formin-mediated actin assembly.

http://www.wikidata.org/entity/Q30491999

description

2009 nî lūn-bûn

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2009 թուականի Նոյեմբերին հրատարակուած գիտական յօդուած

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2009 թվականի նոյեմբերին հրատարակված գիտական հոդված

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2009年の論文

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2009年学术文章

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2009年学术文章

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2009年学术文章

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2009年学术文章

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2009年学术文章

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2009年學術文章

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name

Identification and characteriz ...... ormin-mediated actin assembly.

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Identification and characteriz ...... ormin-mediated actin assembly.

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type

label

Identification and characteriz ...... ormin-mediated actin assembly.

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Identification and characteriz ...... ormin-mediated actin assembly.

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prefLabel

Identification and characteriz ...... ormin-mediated actin assembly.

@ast

Identification and characteriz ...... ormin-mediated actin assembly.

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J.CHEMBIOL.2009.10.006

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Chemistry and Biology

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Identification and characteriz ...... ormin-mediated actin assembly.

@en

P2093

Colleen T Skau

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David R Kovar

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Erin M Neidt

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Jiayue Cui

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Margaret L Gardel

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Sergey A Kozmin

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Syed A Rizvi

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Zach Feiger

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P2860

Fission yeast Sop2p: a novel and evolutionarily conserved protein that interacts with Arp3p and modulates profilin function

A conserved mechanism for Bni1- and mDia1-induced actin assembly and dual regulation of Bni1 by Bud6 and profilin

Cell motility through plasma membrane blebbing

The yeast actin cytoskeleton: from cellular function to biochemical mechanism

Focal contacts as mechanosensors: externally applied local mechanical force induces growth of focal contacts by an mDia1-dependent and ROCK-independent mechanism

FH3, a domain found in formins, targets the fission yeast formin Fus1 to the projection tip during conjugation

Stress fibers are generated by two distinct actin assembly mechanisms in motile cells

Characterization of two classes of small molecule inhibitors of Arp2/3 complex

Formin leaky cap allows elongation in the presence of tight capping proteins.

The formins: active scaffolds that remodel the cytoskeleton

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11

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16

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40035293

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19942139

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2784894

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