Adeno-associated virus gene therapy with cholesterol 24-hydroxylase reduces the amyloid pathology before or after the onset of amyloid plaques in mouse models of Alzheimer's disease. - Wikidata - wikimedia - TriplyDB

Adeno-associated virus gene therapy with cholesterol 24-hydroxylase reduces the amyloid pathology before or after the onset of amyloid plaques in mouse models of Alzheimer's disease.

Adeno-associated virus gene therapy with cholesterol 24-hydroxylase reduces the amyloid pathology before or after the onset of amyloid plaques in mouse models of Alzheimer's disease.

http://www.wikidata.org/entity/Q30493684

about

Structural basis of drug binding to CYP46A1, an enzyme that controls cholesterol turnover in the brain Gene transfer of human Apoe isoforms results in differential modulation of amyloid deposition and neurotoxicity in mouse brain 24S-hydroxycholesterol effects on lipid metabolism genes are modeled in traumatic brain injury Cholesterol balance in prion diseases and Alzheimer's disease Dysregulation of cholesterol balance in the brain: contribution to neurodegenerative diseases Inhibiting cholesterol degradation induces neuronal sclerosis and epileptic activity in mouse hippocampus.Exosome-associated AAV vector as a robust and convenient neuroscience tool In Silico and Intuitive Predictions of CYP46A1 Inhibition by Marketed Drugs with Subsequent Enzyme Crystallization in Complex with Fluvoxamine ACAT1/SOAT1 as a therapeutic target for Alzheimer's disease Enhanced production of 24S-hydroxycholesterol is not sufficient to drive liver X receptor target genes in vivo Targeted delivery of self-complementary adeno-associated virus serotype 9 to the brain, using magnetic resonance imaging-guided focused ultrasound Increasing membrane cholesterol of neurons in culture recapitulates Alzheimer's disease early phenotypes.Cholesterol in the Pathogenesis of Alzheimer's, Parkinson's Diseases and Autism: Link to Synaptic Dysfunction ACAT1 gene ablation increases 24(S)-hydroxycholesterol content in the brain and ameliorates amyloid pathology in mice with AD.Marked variability in hepatic expression of cytochromes CYP7A1 and CYP27A1 as compared to cerebral CYP46A1. Lessons from a dietary study with omega 3 fatty acids in hamsters.The effects of cholesterol on learning and memory.Cholesterol 24-hydroxylase defect is implicated in memory impairments associated with Alzheimer-like Tau pathology.Genetic connections between neurological disorders and cholesterol metabolism Acceleration of gene transfection efficiency in neuroblastoma cells through polyethyleneimine/poly(methyl methacrylate) core-shell magnetic nanoparticles.Cholesterol in brain disease: sometimes determinant and frequently implicated.Is it possible to improve memory function by upregulation of the cholesterol 24S-hydroxylase (CYP46A1) in the brain?Features of the retinal environment which affect the activities and product profile of cholesterol-metabolizing cytochromes P450 CYP27A1 and CYP11A1.CYP46A1, the rate-limiting enzyme for cholesterol degradation, is neuroprotective in Huntington's disease.On the regulatory role of side-chain hydroxylated oxysterols in the brain. Lessons from CYP27A1 transgenic and Cyp27a1(-/-) mice Mapping of the Allosteric Site in Cholesterol Hydroxylase CYP46A1 for Efavirenz, a Drug That Stimulates Enzyme Activity Dyslipidemia and dementia: current epidemiology, genetic evidence, and mechanisms behind the associations.Neuronal cholesterol metabolism increases dendritic outgrowth and synaptic markers via a concerted action of GGTase-I and Trk.Citrulline diet supplementation improves specific age-related raft changes in wild-type rodent hippocampus.Gene therapy in Alzheimer's disease - potential for disease modification Pharmacologic stimulation of cytochrome P450 46A1 and cerebral cholesterol turnover in mice.Genetic therapy for the nervous system.Gene therapy for neurological disorders.In vitro cytochrome P450 46A1 (CYP46A1) activation by neuroactive compounds.Viral vectors for therapy of neurologic diseases.Brain Cholesterol Metabolism and Its Defects: Linkage to Neurodegenerative Diseases and Synaptic Dysfunction.Adeno-Associated Virus-Based Gene Therapy for CNS Diseases.Cellular Cholesterol Homeostasis in Alzheimer's Disease.Okadaic acid inhibits the trichostatin A-mediated increase of human CYP46A1 neuronal expression in a ERK1/2-Sp3-dependent pathway.Neuronal differentiation alters the ratio of Sp transcription factors recruited to the CYP46A1 promoter.CYP46A1 inhibition, brain cholesterol accumulation and neurodegeneration pave the way for Alzheimer's disease.

P2860

Q24293342-D5A8F9AC-3C40-458E-BA74-C84A1EE01091 Q24308258-2C47441E-4685-45BB-BCA3-45E4D8CE1176 Q24644336-D8E920BA-841D-4F8C-A877-E58BE4C68A0F Q27002948-DFDBC3E9-6285-44B1-A94C-6BD538DACBD2 Q27009984-E1340DFF-2456-4A60-B09A-40B6641A22C9 Q27313143-61B51DB3-77FE-457B-A8AA-49C7F77B0DC2 Q27323458-44F5766F-5C80-49C2-A7BC-2EACDBEF99EE Q27671113-A2A9A067-430D-4E7F-9C85-570070DFDDAB Q28081654-AA7F73B4-DB1B-4102-8780-612E86AC0421 Q28235379-676E1B3F-8918-45B3-9E7B-BCB19AB28FAC Q30447740-09F1D10A-9620-4788-A33E-99BB5B4C1B46 Q30612060-51BA18CA-707C-495F-9AE6-1B158E4386E0 Q33607803-F4CD5685-6CBE-403C-BF99-3C6DB3793EBC Q33733667-9874A0FE-F442-4FD5-9AC8-DB1163FDF3E6 Q33835559-0096CCD2-9C64-4D1C-921C-4A0132E1031F Q33976829-DF8EB57C-1198-469F-9FA8-9F802B92A21B Q34044871-32EFAFD0-AAAD-44A3-8FF3-E1BC07D531FF Q34053056-A5D17670-9F66-4192-B2BF-2010718384D2 Q34304899-64392CA8-48E9-409A-AC9C-BD42A79F5572 Q34621446-E24AD6AF-0113-4AB4-BC3D-755A03C60C8A Q34849215-CC6D5163-4E02-48DA-B57E-6CC9D00EE0BF Q35742601-4B00E3D5-40EB-4990-B707-CAC08B38DA37 Q36615488-680755F4-0DA3-4AD4-9BE7-CA4547E0CAFE Q36709582-A9877AA9-63A8-45E2-9033-2351D132570A Q36941138-60304B0F-19A2-4930-81E3-C973BAED0BDC Q36946758-BABB9049-0591-476A-A1C4-470FBAC85B25 Q37153998-7C806CA6-A40B-417B-A778-E05991DFCC8E Q37179936-EDACBE0E-CE9D-4A70-AD76-35867EE405CC Q37295252-3911CBAD-CA20-4716-9232-E3DCCABE4FDC Q37563496-5A1FC02A-6D7F-49D8-B361-E34BC2C6F71B Q37856565-4A0FD275-5539-498C-BCCC-3D9193F1593F Q38661071-FE3AF4AB-BA06-4892-B004-BDF351E49BB1 Q38713074-2DC46E1D-9210-451A-9906-DE8EA8945E02 Q38746238-91B33756-833B-4D50-A5FA-083CF244ABE0 Q38813613-782AF950-8D76-4CC7-BFEA-D9AA1F6F52AF Q38856794-262F311B-E504-4869-A626-6D5946E644EB Q39180626-5435C6E7-AF2D-4FDB-81D2-9459D005E5E3 Q39332138-03D66AFF-4C53-4A56-A2AD-C2E74D54A675 Q39447001-53A3F425-1059-401F-820F-646BDF20A4D8 Q41614229-39307250-8A42-4B78-AA58-71EF1B5A6034

P2860

Adeno-associated virus gene therapy with cholesterol 24-hydroxylase reduces the amyloid pathology before or after the onset of amyloid plaques in mouse models of Alzheimer's disease.

http://www.wikidata.org/entity/Q30493684

description

2009 nî lūn-bûn

@nan

2009 թուականի Օգոստոսին հրատարակուած գիտական յօդուած

@hyw

2009 թվականի օգոստոսին հրատարակված գիտական հոդված

@hy

2009年の論文

@ja

2009年論文

@yue

2009年論文

@zh-hant

2009年論文

@zh-hk

2009年論文

@zh-mo

2009年論文

@zh-tw

2009年论文

@wuu

name

Adeno-associated virus gene th ...... models of Alzheimer's disease.

@ast

Adeno-associated virus gene th ...... models of Alzheimer's disease.

@en

type

label

Adeno-associated virus gene th ...... models of Alzheimer's disease.

@ast

Adeno-associated virus gene th ...... models of Alzheimer's disease.

@en

prefLabel

Adeno-associated virus gene th ...... models of Alzheimer's disease.

@ast

Adeno-associated virus gene th ...... models of Alzheimer's disease.

@en

P1433

Q30493684-B8EB18E1-5C41-4DD3-A085-B173407EBED7

P1476

Q30493684-7216C0F3-D6E8-4E88-82EF-C1A2F851A8D1

P2093

Q30493684-0B2E6E39-FB9B-4812-9E39-5ECA2466249C

Q30493684-1D763C0F-978B-478C-80A5-C36E91D4FFE9

Q30493684-8D0AEFA6-BC2A-465E-B44E-FB5368B377E3

Q30493684-A2D04775-C824-497F-B4F2-DF465591FE4C

Q30493684-A8BED2FC-5206-4688-A4FD-35C67B7A604E

Q30493684-AB3138BF-7785-4285-B77E-3E43F968B22B

Q30493684-C697882A-0FAA-4394-911F-0C715BB577F1

Q30493684-E4B48591-F6ED-4A4B-A6C0-026978DF8182

Q30493684-E5B6005B-1617-45B5-A932-39FD0BF494DC

Q30493684-F754380B-DF2E-48A6-89EF-BE9D00CD3AAF

P2860

Q30493684-038A9695-5415-4849-81AD-48CE2F69C988

Q30493684-08A05445-C843-4F62-8595-939EB322871C

Q30493684-0F20977B-BCB0-4594-AAD5-D7EC766D1BD9

Q30493684-14DF9598-B623-4E2F-94F4-8742138179F8

Q30493684-1CDB929C-21E1-48B2-B753-B6CDDD773354

Q30493684-1FA83050-F997-4E88-A6F4-BE9C69553558

Q30493684-28A50AAA-6DAF-449F-B7EF-1EFBFFC2889E

Q30493684-2CCBD360-5E2E-4E27-937B-0841D7443613

Q30493684-36CBB95A-BD8F-4849-A07F-D14A7D5DAA76

Q30493684-3B481008-F191-4B25-98EC-78DAE45A948E

P304

Q30493684-79839921-6968-430B-87F8-BF6EE5A3D054

P31

Q30493684-6310A6A1-2414-494E-B506-CFDBBF412C2C

P356

Q30493684-231E5BC3-E26B-4A07-92BE-F705B05590A5

P433

Q30493684-A8FEB757-B6AE-4CAF-9B4C-046FA0874E12

P478

Q30493684-3E84BA3C-758F-44BA-962A-7D1E2455F31E

P50

Q30493684-9997AF93-47A9-4DD9-AC42-5FBACD509BDD

P577

Q30493684-DD3295FC-8816-4F5C-92A8-B0E274C91CF6

P5875

Q30493684-C3976D9A-E7A9-4563-9D1C-DD6B9F4FBF1E

P698

Q30493684-AF915C06-F7D2-47E0-A330-EEBD14147992

P921

Q30493684-676acfe7-7c08-4291-8941-6de2b2c1dd59

Q30493684-6D11C8BD-67A8-4D6F-B5AA-4F05D14ACD92

Q30493684-F3869908-8E7A-45C9-872D-AE8212887BD1

P932

Q30493684-6BB340F3-C12F-4FFF-B23D-BF72774938F1

P356

P1433

Molecular Therapy

P1476

Adeno-associated virus gene th ...... models of Alzheimer's disease.

@en

P2093

Abdellatif Benraiss

http://www.w3.org/2001/XMLSchema#string

André Delacourte

http://www.w3.org/2001/XMLSchema#string

Debby Van Dam

http://www.w3.org/2001/XMLSchema#string

Eloise Hudry

http://www.w3.org/2001/XMLSchema#string

Femke S Stet

http://www.w3.org/2001/XMLSchema#string

Nathalie Cartier

http://www.w3.org/2001/XMLSchema#string

Ornella Ahouansou

http://www.w3.org/2001/XMLSchema#string

Patrick Aubourg

http://www.w3.org/2001/XMLSchema#string

Peter P De Deyn

http://www.w3.org/2001/XMLSchema#string

Wim Kulik

http://www.w3.org/2001/XMLSchema#string

P2860

cDNA cloning of cholesterol 24-hydroxylase, a mediator of cholesterol homeostasis in the brain

Apolipoprotein E: high-avidity binding to beta-amyloid and increased frequency of type 4 allele in late-onset familial Alzheimer disease

Association of gamma-secretase with lipid rafts in post-Golgi and endosome membranes.

ApoE promotes the proteolytic degradation of Abeta

Amyloidogenic processing of the Alzheimer beta-amyloid precursor protein depends on lipid rafts

Soluble protein oligomers in neurodegeneration: lessons from the Alzheimer's amyloid beta-peptide

Photoactivated gamma-secretase inhibitors directed to the active site covalently label presenilin 1

Alzheimer's disease: the cholesterol connection

Differential expression of cholesterol hydroxylases in Alzheimer's disease

Abeta-induced inflammatory processes in microglia cells of APP23 transgenic mice

P304

44-53

http://www.w3.org/2001/XMLSchema#string

P31

scholarly article

P356

10.1038/MT.2009.175

http://www.w3.org/2001/XMLSchema#string

P433

1

http://www.w3.org/2001/XMLSchema#string

P478

18

http://www.w3.org/2001/XMLSchema#string

P50

Pierre Bougnères

P577

2009-08-04T00:00:00Z

http://www.w3.org/2001/XMLSchema#dateTime

P5875

245975111

http://www.w3.org/2001/XMLSchema#string

P698

19654569

http://www.w3.org/2001/XMLSchema#string

P921

Alzheimer's disease

P932

2839219

http://www.w3.org/2001/XMLSchema#string