CCM3 signaling through sterile 20-like kinases plays an essential role during zebrafish cardiovascular development and cerebral cavernous malformations - Wikidata - wikimedia - TriplyDB

CCM3 signaling through sterile 20-like kinases plays an essential role during zebrafish cardiovascular development and cerebral cavernous malformations

CCM3 signaling through sterile 20-like kinases plays an essential role during zebrafish cardiovascular development and cerebral cavernous malformations

http://www.wikidata.org/entity/Q30495754

about

CCM3/PDCD10 heterodimerizes with germinal center kinase III (GCKIII) proteins using a mechanism analogous to CCM3 homodimerization Adaptor protein cerebral cavernous malformation 3 (CCM3) mediates phosphorylation of the cytoskeletal proteins ezrin/radixin/moesin by mammalian Ste20-4 to protect cells from oxidative stress Loss of CCM3 impairs DLL4-Notch signalling: implication in endothelial angiogenesis and in inherited cerebral cavernous malformations MST kinases in development and disease Cerebral cavernous malformation is a vascular disease associated with activated RhoA signaling Molecular mechanisms controlling vascular lumen formation in three-dimensional extracellular matrices Micro-CT Imaging Reveals Mekk3 Heterozygosity Prevents Cerebral Cavernous Malformations in Ccm2-Deficient Mice Molecular Recognition of Leucine-Aspartate Repeat (LD) Motifs by the Focal Adhesion Targeting Homology Domain of Cerebral Cavernous Malformation 3 (CCM3)Tiered assembly of the yeast Far3-7-8-9-10-11 complex at the endoplasmic reticulum Cerebral Cavernous Malformations: Review of the Genetic and Protein-Protein Interactions Resulting in Disease Pathogenesis Dynamic regulation of the cerebral cavernous malformation pathway controls vascular stability and growth The transcription factor Atonal homolog 8 regulates Gata4 and Friend of Gata-2 during vertebrate development PDCD10 gene mutations in multiple cerebral cavernous malformations PDCD10/CCM3 acts downstream of {gamma}-protocadherins to regulate neuronal survival.The vasculome of the mouse brain.Loss of cerebral cavernous malformation 3 (Ccm3) in neuroglia leads to CCM and vascular pathology.ccm2-like is required for cardiovascular development as a novel component of the Heg-CCM pathway.Genetics of cerebral cavernous malformations: current status and future prospects A novel non-canonical mechanism of regulation of MST3 (mammalian Sterile20-related kinase 3).ANKS1B Interacts with the Cerebral Cavernous Malformation Protein-1 and Controls Endothelial Permeability but Not Sprouting Angiogenesis.Crystallization and preliminary crystallographic studies of CCM3 in complex with the C-terminal domain of MST4.The cerebral cavernous malformation pathway controls cardiac development via regulation of endocardial MEKK3 signaling and KLF expression.The cerebral cavernous malformation proteins CCM2L and CCM2 prevent the activation of the MAP kinase MEKK3.Arteriovenous malformations and other vascular malformation syndromes.Apicobasal polarity of brain endothelial cells.Cytochrome P450 and matrix metalloproteinase genetic modifiers of disease severity in Cerebral Cavernous Malformation type 1.Loss of endothelial programmed cell death 10 activates glioblastoma cells and promotes tumor growth.Endothelial exocytosis of angiopoietin-2 resulting from CCM3 deficiency contributes to cerebral cavernous malformation.A network of interactions enables CCM3 and STK24 to coordinate UNC13D-driven vesicle exocytosis in neutrophils.Cerebral cavernous malformation proteins at a glance.STRIPAK complexes: structure, biological function, and involvement in human diseases.Ccm3, a gene associated with cerebral cavernous malformations, is required for neuronal migration.The zebrafish model system in cardiovascular research: A tiny fish with mighty prospects.STRIPAK components determine mode of cancer cell migration and metastasis.Signaling pathways and the cerebral cavernous malformations proteins: lessons from structural biology.Cerebral cavernous malformations: from molecular pathogenesis to genetic counselling and clinical management.Endothelial cell-to-cell junctions: adhesion and signaling in physiology and pathology.SOcK, MiSTs, MASK and STicKs: the GCKIII (germinal centre kinase III) kinases and their heterologous protein-protein interactions.CCM1 and the second life of proteins in adhesion complexes.STRIPAK complexes in cell signaling and cancer.

P2860

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P2860

CCM3 signaling through sterile 20-like kinases plays an essential role during zebrafish cardiovascular development and cerebral cavernous malformations

http://www.wikidata.org/entity/Q30495754

description

2010 nî lūn-bûn

@nan

2010 թուականի Յուլիսին հրատարակուած գիտական յօդուած

@hyw

2010 թվականի հուլիսին հրատարակված գիտական հոդված

@hy

2010年の論文

@ja

2010年論文

@yue

2010年論文

@zh-hant

2010年論文

@zh-hk

2010年論文

@zh-mo

2010年論文

@zh-tw

2010年论文

@wuu

name

CCM3 signaling through sterile ...... rebral cavernous malformations

@ast

CCM3 signaling through sterile ...... rebral cavernous malformations

@en

type

label

CCM3 signaling through sterile ...... rebral cavernous malformations

@ast

CCM3 signaling through sterile ...... rebral cavernous malformations

@en

prefLabel

CCM3 signaling through sterile ...... rebral cavernous malformations

@ast

CCM3 signaling through sterile ...... rebral cavernous malformations

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P1433

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P1433

Journal of Clinical Investigation

P1476

CCM3 signaling through sterile ...... rebral cavernous malformations

@en

P2093

Benjamin Kleaveland

http://www.w3.org/2001/XMLSchema#string

Chong Xu

http://www.w3.org/2001/XMLSchema#string

Christoph Seiler

http://www.w3.org/2001/XMLSchema#string

Jie He

http://www.w3.org/2001/XMLSchema#string

Jiping Xiao

http://www.w3.org/2001/XMLSchema#string

Lan Cheng

http://www.w3.org/2001/XMLSchema#string

Mark L Kahn

http://www.w3.org/2001/XMLSchema#string

Mei Chen

http://www.w3.org/2001/XMLSchema#string

Michael A Pack

http://www.w3.org/2001/XMLSchema#string

William C Sessa

http://www.w3.org/2001/XMLSchema#string

P2860

PDCD10 interacts with Ste20-related kinase MST4 to promote cell growth and transformation via modulation of the ERK pathway

Mutations within the MGC4607 gene cause cerebral cavernous malformations

CCM1 and CCM2 protein interactions in cell signaling: implications for cerebral cavernous malformations pathogenesis

Association of Krev-1/rap1a with Krit1, a novel ankyrin repeat-containing protein encoded by a gene mapping to 7q21-22

CCM3 interacts with CCM2 indicating common pathogenesis for cerebral cavernous malformations

Mutations within the programmed cell death 10 gene cause cerebral cavernous malformations

Mutations in a gene encoding a novel protein containing a phosphotyrosine-binding domain cause type 2 cerebral cavernous malformations.

Regulation of cardiovascular development and integrity by the heart of glass-cerebral cavernous malformation protein pathway

KRIT1 is mutated in hyperkeratotic cutaneous capillary-venous malformation associated with cerebral capillary malformation

Mutations in the gene encoding KRIT1, a Krev-1/rap1a binding protein, cause cerebral cavernous malformations (CCM1)

P304

2795-2804

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scholarly article

P356

10.1172/JCI39679

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P407

P433

8

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P478

120

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P50

Annarita Di Lorenzo

Xiangjian Zheng

P577

2010-07-01T00:00:00Z

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P698

20592472

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P921

Aparato circulatorio

P932

2912181

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