A genetic model of amyotrophic lateral sclerosis in zebrafish displays phenotypic hallmarks of motoneuron disease - Wikidata - wikimedia - TriplyDB

A genetic model of amyotrophic lateral sclerosis in zebrafish displays phenotypic hallmarks of motoneuron disease

A genetic model of amyotrophic lateral sclerosis in zebrafish displays phenotypic hallmarks of motoneuron disease

http://www.wikidata.org/entity/Q30496374

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From animal models to human disease: a genetic approach for personalized medicine in ALS Growth differentiation factor 6 as a putative risk factor in neuromuscular degeneration INaP selective inhibition reverts precocious inter- and motorneurons hyperexcitability in the Sod1-G93R zebrafish ALS model FUS and TARDBP but not SOD1 interact in genetic models of amyotrophic lateral sclerosis Temporal requirement for SMN in motoneuron development.Early development of the gonadotropin-releasing hormone neuronal network in transgenic zebrafish Dimerization is required for GARS-mediated neurotoxicity in dominant CMT disease Triggering Cell Stress and Death Using Conventional UV Laser Confocal Microscopy Modelling amyotrophic lateral sclerosis: progress and possibilities A novel ALS-associated variant in UBQLN4 regulates motor axon morphogenesis Kisspeptins modulate the biology of multiple populations of gonadotropin-releasing hormone neurons during embryogenesis and adulthood in zebrafish (Danio rerio).Axonal Transport Defects in a Mitofusin 2 Loss of Function Model of Charcot-Marie-Tooth Disease in Zebrafish.Model systems of motor neuron diseases as a platform for studying pathogenic mechanisms and searching for therapeutic agents.Studying synthetic lethal interactions in the zebrafish system: insight into disease genes and mechanisms.Survival motor neuron affects plastin 3 protein levels leading to motor defects In vivo assessment of contractile strength distinguishes differential gene function in skeletal muscle of zebrafish larvae.Neuromuscular effects of G93A-SOD1 expression in zebrafish.Early interneuron dysfunction in ALS: insights from a mutant sod1 zebrafish model Tardbpl splicing rescues motor neuron and axonal development in a mutant tardbp zebrafish.The wobbler mouse, an ALS animal model.A new zebrafish model produced by TILLING of SOD1-related amyotrophic lateral sclerosis replicates key features of the disease and represents a tool for in vivo therapeutic screening.Microfluidic tools for developmental studies of small model organisms--nematodes, fruit flies, and zebrafish Zebrafish as a model to understand autophagy and its role in neurological disease.Zebrafish as a genomics model for human neurological and polygenic disorders.SOD1 and TDP-43 animal models of amyotrophic lateral sclerosis: recent advances in understanding disease toward the development of clinical treatments.Molecular pathways of motor neuron injury in amyotrophic lateral sclerosis.Using induced pluripotent stem cells (iPSC) to model human neuromuscular connectivity: promise or reality?Neuromuscular disorders in zebrafish: state of the art and future perspectives.Mitophagy and neurodegeneration: the zebrafish model system.Fishing for causes and cures of motor neuron disorders.Loss and gain of FUS function impair neuromuscular synaptic transmission in a genetic model of ALS.Simple animal models for amyotrophic lateral sclerosis drug discovery.Potential new complication in drug therapy development for amyotrophic lateral sclerosis.Zebrafish models in neuropsychopharmacology and CNS drug discovery.ZNStress: a high-throughput drug screening protocol for identification of compounds modulating neuronal stress in the transgenic mutant sod1G93R zebrafish model of amyotrophic lateral sclerosis Generation and Characterization of a genetic zebrafish model of SMA carrying the human SMN2 gene.Canine degenerative myelopathy: biochemical characterization of superoxide dismutase 1 in the first naturally occurring non-human amyotrophic lateral sclerosis model.A zebrafish model exemplifies the long preclinical period of motor neuron disease.Genomic editing opens new avenues for zebrafish as a model for neurodegeneration.Atomic structure of a toxic, oligomeric segment of SOD1 linked to amyotrophic lateral sclerosis (ALS).

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A genetic model of amyotrophic lateral sclerosis in zebrafish displays phenotypic hallmarks of motoneuron disease

http://www.wikidata.org/entity/Q30496374

description

2010 nî lūn-bûn

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2010 թուականի Մայիսին հրատարակուած գիտական յօդուած

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2010 թվականի մայիսին հրատարակված գիտական հոդված

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2010年の論文

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2010年論文

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2010年論文

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2010年論文

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2010年論文

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2010年论文

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A genetic model of amyotrophic ...... allmarks of motoneuron disease

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A genetic model of amyotrophic ...... allmarks of motoneuron disease

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Disease Models & Mechanisms

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A genetic model of amyotrophic ...... allmarks of motoneuron disease

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Alison N Lyon

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Benjamin D Canan

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Christine E Beattie

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Chunping Wang

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Ricardo H Pineda

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Tennore Ramesh

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How common are the "common" neurologic disorders?

Targeted gene inactivation in zebrafish using engineered zinc-finger nucleases

Heritable targeted gene disruption in zebrafish using designed zinc-finger nucleases

Amyotrophic lateral sclerosis and structural defects in Cu,Zn superoxide dismutase

Mutations in Cu/Zn superoxide dismutase gene are associated with familial amyotrophic lateral sclerosis

Early and selective loss of neuromuscular synapse subtypes with low sprouting competence in motoneuron diseases

Motor neuron degeneration in mice that express a human Cu,Zn superoxide dismutase mutation

A highly efficient recombineering-based method for generating conditional knockout mutations

Animal models of human disease: zebrafish swim into view

Automatic and quantitative measurement of protein-protein colocalization in live cells.

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9-10

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3

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44632685

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20504969

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amyotrophic lateral sclerosis

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2931540

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