Antiphospholipid antibodies promote leukocyte-endothelial cell adhesion and thrombosis in mice by antagonizing eNOS via β2GPI and apoER2. - Wikidata - wikimedia - TriplyDB

Antiphospholipid antibodies promote leukocyte-endothelial cell adhesion and thrombosis in mice by antagonizing eNOS via β2GPI and apoER2.

Antiphospholipid antibodies promote leukocyte-endothelial cell adhesion and thrombosis in mice by antagonizing eNOS via β2GPI and apoER2.

http://www.wikidata.org/entity/Q30497721

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Loss of Reelin protects against atherosclerosis by reducing leukocyte-endothelial cell adhesion and lesion macrophage accumulation A novel pathway for human endothelial cell activation by antiphospholipid/anti-β2 glycoprotein I antibodies.Inhibition of nitric oxide and antiphospholipid antibody-mediated thrombosis.The cholesterol metabolite 27-hydroxycholesterol promotes atherosclerosis via proinflammatory processes mediated by estrogen receptor alpha.Platelets are required for enhanced activation of the endothelium and fibrinogen in a mouse thrombosis model of APS.Apolipoprotein E receptor-2 deficiency enhances macrophage susceptibility to lipid accumulation and cell death to augment atherosclerotic plaque progression and necrosis.Genetic variants of ApoE and ApoER2 differentially modulate endothelial function.Pathophysiology of thrombosis and pregnancy morbidity in the antiphospholipid syndrome.Antiphospholipid antibodies attenuate endothelial repair and promote neointima formation in mice.An A1-A1 mutant with improved binding and inhibition of β2GPI/antibody complexes in antiphospholipid syndrome.A Subregion of Reelin Suppresses Lipoprotein-Induced Cholesterol Accumulation in Macrophages.Identification of a Monoclonal Antibody That Attenuates Antiphospholipid Syndrome-Related Pregnancy Complications and Thrombosis.Apelin/APJ signaling is a critical regulator of statin effects in vascular endothelial cells--brief report.ApoE Receptor 2 Mediation of Trophoblast Dysfunction and Pregnancy Complications Induced by Antiphospholipid Antibodies in Mice Soluble analog of ApoER2 targeting beta2-glycoprotein I in immune complexes counteracts hypertension in lupus-prone mice with spontaneous antiphospholipid syndrome Anti-β2GPI antibodies stimulate endothelial cell microparticle release via a nonmuscle myosin II motor protein-dependent pathway.A novel TRPV4-specific agonist inhibits monocyte adhesion and atherosclerosis.Prevalence of anti- beta2GPI antibodies and their isotypes in patients with renal diseases and clinical suspicion of antiphospholipid syndrome Recent advances in understanding antiphospholipid syndrome.Inhibition of thrombotic properties of persistent autoimmune anti-β2GPI antibodies in the mouse model of antiphospholipid syndrome The Utility of Ovotransferrin and Ovotransferrin-Derived Peptides as Possible Candidates in the Clinical Treatment of Cardiovascular Diseases β(2) -Glycoprotein I: evolution, structure and function.Pathogenesis of antiphospholipid syndrome: understanding the antibodies.Endothelium--role in regulation of coagulation and inflammation.Recent developments in our understanding of the antiphospholipid syndrome.New Insights into the Molecular Basis of the Antiphospholipid Syndrome.Movement disorders in systemic lupus erythematosus and the antiphospholipid syndrome.The current standing of diagnosis of antiphospholipid syndrome associated with systemic lupus erythematosus.The journey of antiphospholipid antibodies from cellular activation to antiphospholipid syndrome.Clinical Risk Assessment in the Antiphospholipid Syndrome: Current Landscape and Emerging Biomarkers.Antiphospholipid syndrome: an update for clinicians and scientists.Renal involvement in primary antiphospholipid syndrome.Reprogramming Bone Marrow Stem Cells to Functional Endothelial Cells in a Mini Pig Animal Model H(2)S inhibits oscillatory shear stress-induced monocyte binding to endothelial cells via nitric oxide production.Circulating anti-beta2-glycoprotein I antibodies are associated with endothelial dysfunction, inflammation, and high nitrite plasma levels in patients with intermittent claudication.Activated signature of antiphospholipid syndrome neutrophils reveals potential therapeutic target Identification of the binding site for fondaparinux on Beta2-glycoprotein I.Low molecular weight heparin and aspirin exacerbate human endometrial endothelial cell responses to antiphospholipid antibodies.Antiphospholipid antibody-induced cellular responses depend on epitope specificity : implications for treatment of antiphospholipid syndrome.Is there a link between mean platelet volume and thrombotic events in antiphospholipid syndrome?

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P2860

Antiphospholipid antibodies promote leukocyte-endothelial cell adhesion and thrombosis in mice by antagonizing eNOS via β2GPI and apoER2.

http://www.wikidata.org/entity/Q30497721

description

2010 nî lūn-bûn

@nan

2010 թուականի Դեկտեմբերին հրատարակուած գիտական յօդուած

@hyw

2010 թվականի դեկտեմբերին հրատարակված գիտական հոդված

@hy

2010年の論文

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2010年論文

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2010年論文

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2010年論文

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2010年論文

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2010年論文

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2010年论文

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name

Antiphospholipid antibodies pr ...... ing eNOS via β2GPI and apoER2.

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Antiphospholipid antibodies pr ...... ing eNOS via β2GPI and apoER2.

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Antiphospholipid antibodies pr ...... ing eNOS via β2GPI and apoER2.

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Journal of Clinical Investigation

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Antiphospholipid antibodies pr ...... zing eNOS via β2GPI and apoER2

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P2093

Chieko Mineo

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Craig N Morrell

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Ivan S Yuhanna

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Jane E Salmon

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Joachim Herz

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Philip E Thorpe

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Philip G de Groot

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Philip W Shaul

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Sangeetha Ramesh

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P2860

Reeler/Disabled-like disruption of neuronal migration in knockout mice lacking the VLDL receptor and ApoE receptor 2

Identification of a novel exon in apolipoprotein E receptor 2 leading to alternatively spliced mRNAs found in cells of the vascular wall but not in neuronal tissue

Anti-phospholipid antibodies are directed against a complex antigen that includes a lipid-binding inhibitor of coagulation: beta 2-glycoprotein I (apolipoprotein H)

Signal transduction of eNOS activation

Apolipoprotein E (apoE) isoforms differentially induce nitric oxide production in endothelial cells

Regulation of endothelial nitric oxide synthase: location, location, location

Annexin A5 as a novel player in prevention of atherothrombosis in SLE and in the general population

39-kDa protein modulates binding of ligands to low density lipoprotein receptor-related protein/alpha 2-macroglobulin receptor

International consensus statement on an update of the classification criteria for definite antiphospholipid syndrome (APS)

Neuronal nitric oxide synthase (NOS) regulates leukocyte-endothelial cell interactions in endothelial NOS deficient mice

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120-131

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10.1172/JCI39828

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1

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121

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Guillermina Girardi

Cristina Tarango

Rolf T. Urbanus

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2010-12-01T00:00:00Z

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21123944

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3007129

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