RGS/Gi2alpha interactions modulate platelet accumulation and thrombus formation at sites of vascular injury
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Platelet signalingTACTIC: Trans-Agency Consortium for Trauma-Induced CoagulopathyRegulator of G-protein signaling 18 controls both platelet generation and function.The loss of RGS protein-Gα(i2) interactions results in markedly impaired mouse neutrophil trafficking to inflammatory sites.Hierarchical organization in the hemostatic response and its relationship to the platelet-signaling network.Regulators of G-protein signaling and their Gα substrates: promises and challenges in their use as drug discovery targets.An essential role for RGS protein/Gαi2 interactions in B lymphocyte-directed cell migration and traffickingDissociation of SHP-1 from spinophilin during platelet activation exposes an inhibitory binding site for protein phosphatase-1 (PP1)Platelet Gi protein Gαi2 is an essential mediator of thrombo-inflammatory organ damage in mice.A newly identified complex of spinophilin and the tyrosine phosphatase, SHP-1, modulates platelet activation by regulating G protein-dependent signaling.RGS10 Negatively Regulates Platelet Activation and Thrombogenesis.Modulating platelet reactivity through control of RGS18 availability.Live imaging of extracellular signal-regulated kinase and protein kinase A activities during thrombus formation in mice expressing biosensors based on Förster resonance energy transfer.Human genome-wide association and mouse knockout approaches identify platelet supervillin as an inhibitor of thrombus formation under shear stressA systems approach to hemostasis: 4. How hemostatic thrombi limit the loss of plasma-borne molecules from the microvasculature.Regulating thrombus growth and stability to achieve an optimal response to injury.Regulators of G protein signaling: role in hematopoiesis, megakaryopoiesis and platelet function.Harnessing the platelet signaling network to produce an optimal hemostatic response.Spatiotemporal regulation of coagulation and platelet activation during the hemostatic response in vivo.The impact of RGS and other G-protein regulatory proteins on Gαi-mediated signaling in immunity.Normal Thymocyte Egress, T Cell Trafficking, and CD4+ T Cell Homeostasis Require Interactions between RGS Proteins and Gαi2.Paxillin is an intrinsic negative regulator of platelet activation in mice.Filling GAPs in the understanding of cardioprotection induced by GPCR activation: RGS proteins modulate ischaemic injury.Negative regulators of platelet activation and adhesion.New single nucleotide polymorphisms associated with differences in platelets reactivity in patients with type 2 diabetes treated with acetylsalicylic acid: genome-wide association approach and pooled DNA strategy.RGS10 shapes the hemostatic response to injury through its differential effects on intracellular signaling by platelet agonists
P2860
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P2860
RGS/Gi2alpha interactions modulate platelet accumulation and thrombus formation at sites of vascular injury
description
2010 nî lūn-bûn
@nan
2010 թուականի Սեպտեմբերին հրատարակուած գիտական յօդուած
@hyw
2010 թվականի սեպտեմբերին հրատարակված գիտական հոդված
@hy
2010年の論文
@ja
2010年論文
@yue
2010年論文
@zh-hant
2010年論文
@zh-hk
2010年論文
@zh-mo
2010年論文
@zh-tw
2010年论文
@wuu
name
RGS/Gi2alpha interactions modu ...... on at sites of vascular injury
@ast
RGS/Gi2alpha interactions modu ...... on at sites of vascular injury
@en
type
label
RGS/Gi2alpha interactions modu ...... on at sites of vascular injury
@ast
RGS/Gi2alpha interactions modu ...... on at sites of vascular injury
@en
prefLabel
RGS/Gi2alpha interactions modu ...... on at sites of vascular injury
@ast
RGS/Gi2alpha interactions modu ...... on at sites of vascular injury
@en
P2093
P2860
P1433
P1476
RGS/Gi2alpha interactions modu ...... on at sites of vascular injury
@en
P2093
Aleksandra Cierniewska
Karen P Fong
Lawrence F Brass
Manash S Chatterjee
Paul R Hess
Peisong Ma
Rachel S Signarvic
Scott L Diamond
P2860
P304
P356
10.1182/BLOOD-2010-05-283846
P407
P577
2010-09-17T00:00:00Z