Catalytic mechanism of RNA backbone cleavage by ribonuclease H from quantum mechanics/molecular mechanics simulations.
about
Role of magnesium ions in the reaction mechanism at the interface between Tm1631 protein and its DNA ligand.3′-Processing and strand transfer catalysed by retroviral integrasein crystalloNovel complex MAD phasing and RNase H structural insights using selenium oligonucleotidesVisualizing phosphodiester-bond hydrolysis by an endonucleaseGeneralized Ensemble Sampling of Enzyme Reaction Free Energy PathwaysRetroviral DNA IntegrationRevelation of a catalytic calcium-binding site elucidates unusual metal dependence of a human apyraseQuantum mechanical/molecular mechanical free energy simulations of the self-cleavage reaction in the hepatitis delta virus ribozyme.Hydrolysis of DFP and the nerve agent (S)-sarin by DFPase proceeds along two different reaction pathways: implications for engineering bioscavengers.Evidence from molecular dynamics simulations of conformational preorganization in the ribonuclease H active site.Fast exploration of an optimal path on the multidimensional free energy surfaceComprehensive classification of the PIN domain-like superfamilyComputing the Free Energy along a Reaction Coordinate Using Rigid Body DynamicsCalcium inhibition of ribonuclease H1 two-metal ion catalysisConvergent transmission of RNAi guide-target mismatch information across Argonaute internal allosteric network.Retroviral Integrase Structure and DNA Recombination MechanismRole of the active site guanine in the glmS ribozyme self-cleavage mechanism: quantum mechanical/molecular mechanical free energy simulationsConvergence and error estimation in free energy calculations using the weighted histogram analysis methodAn abridged transition state model to derive structure, dynamics, and energy components of DNA polymerase β fidelity.Metal and ligand binding to the HIV-RNase H active site are remotely monitored by Ile556Molecular simulations of RNA 2'-O-transesterification reaction models in solution.Efficient Determination of Free Energy Landscapes in Multiple Dimensions from Biased Umbrella Sampling Simulations Using Linear Regression.Stabilization of different types of transition states in a single enzyme active site: QM/MM analysis of enzymes in the alkaline phosphatase superfamily.Toward Determining ATPase Mechanism in ABC Transporters: Development of the Reaction Path-Force Matching QM/MM Method.The emerging diversity of transpososome architectures.Understanding in-line probing experiments by modeling cleavage of nonreactive RNA nucleotides.Quantum Mechanical/Molecular Mechanical Study of the HDV Ribozyme: Impact of the Catalytic Metal Ion on the Mechanism.Inverse thio effects in the hepatitis delta virus ribozyme reveal that the reaction pathway is controlled by metal ion charge density.Bayesian ensemble refinement by replica simulations and reweighting.Theoretical studies of energetics and binding isotope effects of binding a triazole-based inhibitor to HIV-1 reverse transcriptase.Assessing the Potential Effects of Active Site Mg2+ Ions in the glmS Ribozyme-Cofactor ComplexEvidence for a dual functional role of a conserved histidine in RNA·DNA heteroduplex cleavage by human RNase H1.HIV-1 Reverse Transcriptase Still Remains a New Drug Target: Structure, Function, Classical Inhibitors, and New Inhibitors with Innovative Mechanisms of Actions.Cas9-catalyzed DNA Cleavage Generates Staggered Ends: Evidence from Molecular Dynamics Simulations.Exploring the mechanism of DNA polymerases by analyzing the effect of mutations of active site acidic groups in Polymerase βRNA Structural Dynamics As Captured by Molecular Simulations: A Comprehensive Overview.Peptide dimerization-dissociation rates from replica exchange molecular dynamics.Computational Simulations of DNA Polymerases: Detailed Insights on Structure/Function/Mechanism from Native Proteins to Cancer Variants.Regulation and Plasticity of Catalysis in Enzymes: Insights from Analysis of Mechanochemical Coupling in Myosin.Glutamine Amide Flip Elicits Long Distance Allosteric Responses in the LOV Protein Vivid.
P2860
Q27331029-D3D929AB-D4C6-4F48-B413-99CD92C939A1Q27679066-33A4B34F-1121-4BAB-83AA-542F48624EDAQ27681758-0AC8213C-9EF3-44EB-8481-6868AC8C5471Q27696542-8E9CE9B8-2F16-4F52-B696-99027369A2BEQ28553422-41D25C67-29F0-41E4-B440-E65C19C17CCEQ28596842-022ED9F4-043F-47B1-942B-772231648068Q30559643-94695534-238F-4AE0-9B58-F2545D68DBA2Q30574062-FE6486C8-164B-4985-B743-2D245C8E6D9CQ33567108-6FAB1A20-8197-423B-9B1D-F0CC73776852Q33654266-C3AD1E0F-2536-49ED-AB39-FBAFFA67B29BQ33704110-3FB6448F-9D69-461A-9D8D-DBBBD417F1D6Q33878209-FE2708C6-F78E-4CA6-BEC5-77447AC44CE9Q34337357-4DF868E2-2490-4DE4-9753-3A6EB2E7B69DQ34402463-82EC2D82-434A-4ED2-9903-739E25B39427Q34426370-C97A04C8-A4F3-433E-8C22-7E2D9E71C064Q34668065-85300461-E200-434E-A49B-F2E8F770DB8CQ35020704-EC2D4ED4-2044-4B42-A55F-A86DDCA4132BQ35734759-A4EC7D88-ACAD-4BF8-B8E2-CA7E39964EACQ36335330-996BD54A-04FF-4722-88F9-407368A08AC0Q36368801-AE39A4DE-B41F-47BB-96AC-370363FA25DCQ36616106-49692F2F-CA8A-4998-9E1D-2F6211864B56Q36972268-A11A82BC-9DA5-47CD-A5F4-7982882D40EFQ37137337-6285DE52-8AB6-42AA-8625-3795E604902AQ37175775-E3BBDF70-6319-40D7-BFCF-E1A0AD3E2FE6Q38065357-B677BD90-3B6C-4E79-BD29-8DD8913605BBQ38959329-CB27A6A0-D18B-424B-9D02-0D69B9D1D27DQ39669410-1EC96F9C-C453-464F-9D2E-F21E8563A212Q39959277-988B0E5A-9AD7-493F-9904-CBF1FA7BD3ECQ40152204-BA1002A6-6BF2-4161-A151-5CAC7B09C039Q41092565-E6CC09A6-333F-4D13-B422-5E520F1FDB3EQ41675293-0A37E980-7178-45E9-9CEF-27FD7068F2CAQ41863852-2DB19C8F-4166-430F-BEA7-EA8E797570D4Q41879018-AC24D074-6ABF-4FDF-92E1-99F46575ED33Q42364944-EF03A110-FC01-49F0-AF18-C61AA563E2B3Q42598180-D0875B75-3891-40F5-B770-445309001E7BQ47235409-D7C74237-A75D-48A4-ADF6-FB295F4D75B1Q47749949-B1C96E01-AF97-4522-8615-8FEAFFC22507Q47848185-B590EDA6-151D-46CB-9D45-87D6E4F878CDQ48046709-D24BBC0A-08F6-46C4-A3D6-5A6A5C80903BQ48048450-0D6F38F6-A5FB-49AB-AFF6-7AA2C6642285
P2860
Catalytic mechanism of RNA backbone cleavage by ribonuclease H from quantum mechanics/molecular mechanics simulations.
description
2011 nî lūn-bûn
@nan
2011 թուականի Մայիսին հրատարակուած գիտական յօդուած
@hyw
2011 թվականի մայիսին հրատարակված գիտական հոդված
@hy
2011年の論文
@ja
2011年論文
@yue
2011年論文
@zh-hant
2011年論文
@zh-hk
2011年論文
@zh-mo
2011年論文
@zh-tw
2011年论文
@wuu
name
Catalytic mechanism of RNA bac ...... lecular mechanics simulations.
@ast
Catalytic mechanism of RNA bac ...... lecular mechanics simulations.
@en
type
label
Catalytic mechanism of RNA bac ...... lecular mechanics simulations.
@ast
Catalytic mechanism of RNA bac ...... lecular mechanics simulations.
@en
prefLabel
Catalytic mechanism of RNA bac ...... lecular mechanics simulations.
@ast
Catalytic mechanism of RNA bac ...... lecular mechanics simulations.
@en
P2860
P356
P1476
Catalytic mechanism of RNA bac ...... lecular mechanics simulations.
@en
P2093
Marcin Nowotny
P2860
P304
P356
10.1021/JA200173A
P407
P577
2011-05-24T00:00:00Z