Muscle-derived stem/progenitor cell dysfunction limits healthspan and lifespan in a murine progeria model. - Wikidata - wikimedia - TriplyDB

Muscle-derived stem/progenitor cell dysfunction limits healthspan and lifespan in a murine progeria model.

Muscle-derived stem/progenitor cell dysfunction limits healthspan and lifespan in a murine progeria model.

http://www.wikidata.org/entity/Q30504731

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Hallmarks of progeroid syndromes: lessons from mice and reprogrammed cells Molecular insights into the premature aging disease progeria Health Span-Extending Activity of Human Amniotic Membrane- and Adipose Tissue-Derived Stem Cells in F344 Rats.A cautionary tale for autologous vascular tissue engineering: impact of human demographics on the ability of adipose-derived mesenchymal stem cells to recruit and differentiate into smooth muscle cells.Impact of aging on the regenerative properties of bone marrow-, muscle-, and adipose-derived mesenchymal stem/stromal cells Impaired skeletal muscle regeneration in the absence of fibrosis during hibernation in 13-lined ground squirrels The hallmarks of aging Human muscle-derived stem/progenitor cells promote functional murine peripheral nerve regeneration.Aging mesenchymal stem cells fail to protect because of impaired migration and antiinflammatory response.Inhibition of NF-κB improves the stress resistance and myogenic differentiation of MDSPCs isolated from naturally aged mice Involvement of ERCC1 in the pathogenesis of osteoarthritis through the modulation of apoptosis and cellular senescence.Alive and well? Exploring disease by studying lifespan.Coaxing stem cells for skeletal muscle repair The altered fate of aging satellite cells is determined by signaling and epigenetic changes.Cardiac aging - Getting to the stem of the problem.Comparison of mice with accelerated aging caused by distinct mechanisms Journey of mesenchymal stem cells for homing: strategies to enhance efficacy and safety of stem cell therapy.Can a young muscle's stem cell secretome prolong our lives?Lmo7 is dispensable for skeletal muscle and cardiac function.Non-passaged muscle precursor cells from 32-month old rat skeletal muscle have delayed proliferation and differentiation.Role of stem/progenitor cells in reparative disorders.Translating advances from the basic biology of aging into clinical application SIRT6 safeguards human mesenchymal stem cells from oxidative stress by coactivating NRF2.Genotoxic stress accelerates age-associated degenerative changes in intervertebral discs Long-term functional engraftment of mesenchymal progenitor cells in a mouse model of accelerated aging Cell autonomous and nonautonomous mechanisms drive hematopoietic stem/progenitor cell loss in the absence of DNA repair.DNA damage drives accelerated bone aging via an NF-κB-dependent mechanism.Regenerating the injured kidney with human umbilical cord mesenchymal stem cell-derived exosomes.Muscle-derived stem/progenitor cell dysfunction in Zmpste24-deficient progeroid mice limits muscle regeneration.Isolation of muscle-derived stem/progenitor cells based on adhesion characteristics to collagen-coated surfaces Prelamin A causes progeria through cell-extrinsic mechanisms and prevents cancer invasion.Basic biology of skeletal aging: role of stress response pathways.Identification of microRNAs dysregulated in cellular senescence driven by endogenous genotoxic stress.The influence of skeletal muscle on systemic aging and lifespan.Human Induced Pluripotent Stem Cells Differentiate Into Functional Mesenchymal Stem Cells and Repair Bone Defects Stem cell death and survival in heart regeneration and repair.Influence of age on wound healing and fibrosis.Age-associated changes in the ecological niche: implications for mesenchymal stem cell aging.Methods for the discovery of new anti-aging products--targeted approaches.Advances in Therapeutic Approaches to Extend Healthspan: a perspective from the 2nd Scripps Symposium on the Biology of Aging.

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Muscle-derived stem/progenitor cell dysfunction limits healthspan and lifespan in a murine progeria model.

http://www.wikidata.org/entity/Q30504731

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Muscle-derived stem/progenitor ...... an in a murine progeria model.

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Nature Communications

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Muscle-derived stem/progenitor ...... an in a murine progeria model.

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Aiping Lu

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Andria R Robinson

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Bahar Ahani

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Chelsea H Feldman

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Jeremy S Tilstra

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Johnny Huard

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Joseph M Feduska

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Minjung Song

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Mitra Lavasani

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P2860

Lamin A-dependent misregulation of adult stem cells associated with accelerated ageing

Hmga2 promotes neural stem cell self-renewal in young but not old mice by reducing p16Ink4a and p19Arf Expression

A perivascular origin for mesenchymal stem cells in multiple human organs

Bmi-1 is required for maintenance of adult self-renewing haematopoietic stem cells

Physiological consequences of defects in ERCC1-XPF DNA repair endonuclease

Neurogenesis in the dentate gyrus of the adult rat: age-related decrease of neuronal progenitor proliferation

A new progeroid syndrome reveals that genotoxic stress suppresses the somatotroph axis

Effects of aging and niche microenvironment on spermatogonial stem cell self-renewal

Disruption of mouse ERCC1 results in a novel repair syndrome with growth failure, nuclear abnormalities and senescence

Posterior transformation, neurological abnormalities, and severe hematopoietic defects in mice with a targeted deletion of the bmi-1 proto-oncogene

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10.1038/NCOMMS1611

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