Rescue from excitotoxicity and axonal degeneration accompanied by age-dependent behavioral and neuroanatomical alterations in caspase-6-deficient mice.
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A Huntingtin-based peptide inhibitor of caspase-6 provides protection from mutant Huntingtin-induced motor and behavioral deficits.Executioner Caspase-3 and 7 Deficiency Reduces Myocyte Number in the Developing Mouse HeartCaspase vinyl sulfone small molecule inhibitors prevent axonal degeneration in human neurons and reverse cognitive impairment in Caspase-6-overexpressing mice.Distinct pathways mediate axon degeneration during apoptosis and axon-specific pruningCaspase-6 does not contribute to the proteolysis of mutant huntingtin in the HdhQ150 knock-in mouse model of Huntington's diseaseInflammation-induced tumorigenesis in mouse colon is caspase-6 independent.Expression and activation of caspase-6 in human fetal and adult tissuesTranscriptomic analysis unveils correlations between regulative apoptotic caspases and genes of cholesterol homeostasis in human brain.Sox11 Reduces Caspase-6 Cleavage and Activity.Caspase-6 activity in a BACHD mouse modulates steady-state levels of mutant huntingtin protein but is not necessary for production of a 586 amino acid proteolytic fragment.A caspase cascade regulating developmental axon degeneration.Does Caspase-6 Have a Role in Perinatal Brain Injury?A Rare Recurrent 4q25 Proximal Deletion Not Involving the PITX2 Gene: A Genomic Disorder Distinct from Axenfeld-Rieger Syndrome.Cerebrospinal fluid tau cleaved by caspase-6 reflects brain levels and cognition in aging and Alzheimer diseaseIncreased Caspase-6 activity in the human anterior olfactory nuclei of the olfactory bulb is associated with cognitive impairment.Axon degeneration is key component of neuronal death in amyloid-β toxicity.Extracellular caspase-6 drives murine inflammatory pain via microglial TNF-α secretionCaspase-6 activity in the CA1 region of the hippocampus induces age-dependent memory impairment.Caspase-6 as a novel early target in the treatment of Alzheimer's disease.Concepts for regulation of axon integrity by enwrapping glia.Methylene Blue Inhibits Caspases by Oxidation of the Catalytic Cysteine.Targeting TEAD/YAP-transcription-dependent necrosis, TRIAD, ameliorates Huntington's disease pathology.Identification of Caspase-6 as a New Regulator of Alternatively Activated Macrophages.Neuronal NLRP1 inflammasome activation of Caspase-1 coordinately regulates inflammatory interleukin-1-beta production and axonal degeneration-associated Caspase-6 activation.Peptide inhibitors: Four of a kind beats a pair.Activation of caspase-6 and cleavage of caspase-6 substrates is an early event in NMDA receptor-mediated excitotoxicity.Probing the correlation of neuronal loss, neurofibrillary tangles, and cell death markers across the Alzheimer's disease Braak stages: a quantitative study in humans.Death Receptor 6 and Caspase-6 Regulate Prion Peptide-Induced Axonal Degeneration in Rat Spinal Neurons.Differential susceptibility of striatal, hippocampal and cortical neurons to Caspase-6.Rare human Caspase-6-R65W and Caspase-6-G66R variants identify a novel regulatory region of Caspase-6 activity.Constitutive ablation of caspase-6 reduces the inflammatory response and behavioural changes caused by peripheral pro-inflammatory stimuli.
P2860
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P2860
Rescue from excitotoxicity and axonal degeneration accompanied by age-dependent behavioral and neuroanatomical alterations in caspase-6-deficient mice.
description
2012 nî lūn-bûn
@nan
2012 թուականի Յունուարին հրատարակուած գիտական յօդուած
@hyw
2012 թվականի հունվարին հրատարակված գիտական հոդված
@hy
2012年の論文
@ja
2012年論文
@yue
2012年論文
@zh-hant
2012年論文
@zh-hk
2012年論文
@zh-mo
2012年論文
@zh-tw
2012年论文
@wuu
name
Rescue from excitotoxicity and ...... s in caspase-6-deficient mice.
@ast
Rescue from excitotoxicity and ...... s in caspase-6-deficient mice.
@en
type
label
Rescue from excitotoxicity and ...... s in caspase-6-deficient mice.
@ast
Rescue from excitotoxicity and ...... s in caspase-6-deficient mice.
@en
prefLabel
Rescue from excitotoxicity and ...... s in caspase-6-deficient mice.
@ast
Rescue from excitotoxicity and ...... s in caspase-6-deficient mice.
@en
P2093
P2860
P356
P1476
Rescue from excitotoxicity and ...... s in caspase-6-deficient mice.
@en
P2093
Amanda Spreeuw
Bibiana K Y Wong
Corey L Cusack
Dagmar E Ehrnhoefer
David Howland
Freda D Miller
Konstantin Feinberg
Kuljeet Vaid
Mahmoud A Pouladi
Mohanish Deshmukh
P2860
P304
P356
10.1093/HMG/DDS005
P577
2012-01-18T00:00:00Z