CLEC-2 and Syk in the megakaryocytic/platelet lineage are essential for development. - Wikidata - wikimedia - TriplyDB

CLEC-2 and Syk in the megakaryocytic/platelet lineage are essential for development.

CLEC-2 and Syk in the megakaryocytic/platelet lineage are essential for development.

http://www.wikidata.org/entity/Q30514065

about

Development of the mammalian lymphatic vasculature Platelet adhesion to podoplanin under flow is mediated by the receptor CLEC-2 and stabilised by Src/Syk-dependent platelet signalling.Proteasome function is required for platelet production Critical Role for an acidic amino acid region in platelet signaling by the HemITAM (hemi-immunoreceptor tyrosine-based activation motif) containing receptor CLEC-2 (C-type lectin receptor-2).Syk and Src family kinases regulate C-type lectin receptor 2 (CLEC-2)-mediated clustering of podoplanin and platelet adhesion to lymphatic endothelial cells.Platelet ITAM signaling is critical for vascular integrity in inflammation.Adoptive transfer method to study platelet function in mouse models of disease.The N-terminal SH2 domain of Syk is required for (hem)ITAM, but not integrin, signaling in mouse platelets.Targeted downregulation of platelet CLEC-2 occurs through Syk-independent internalization.Platelets are versatile cells: New discoveries in hemostasis, thrombosis, immune responses, tumor metastasis and beyond.Syk Inhibition Induces Platelet Dependent Peri-islet Hemorrhage in the Rat Pancreas.Mutation of threonine 34 in mouse podoplanin-Fc reduces CLEC-2 binding and toxicity in vivo while retaining antilymphangiogenic activity.CLEC-2-dependent activation of mouse platelets is weakly inhibited by cAMP but not by cGMP CLEC-2 expression is maintained on activated platelets and on platelet microparticles.Lineage tracing of Pf4-Cre marks hematopoietic stem cells and their progeny.Vascular Smooth Muscle Cells Stimulate Platelets and Facilitate Thrombus Formation through Platelet CLEC-2: Implications in Atherothrombosis.Phospholipase Cγ2 Is Required for Luminal Expansion of the Epididymal Duct during Postnatal Development in Mice.CLEC-2 in megakaryocytes is critical for maintenance of hematopoietic stem cells in the bone marrow.Inflammation drives thrombosis after Salmonella infection via CLEC-2 on platelets.Fucoidan is a novel platelet agonist for the C-type lectin-like receptor 2 (CLEC-2)Discoidin domain receptor 1 protein is a novel modulator of megakaryocyte-collagen interactions A critical role of platelet TGF-β release in podoplanin-mediated tumour invasion and metastasis.Platelet immunoreceptor tyrosine-based activation motif (ITAM) signaling and vascular integrity.Platelet receptors activated via mulitmerization: glycoprotein VI, GPIb-IX-V, and CLEC-2.The functional role of platelets in the regulation of angiogenesis.Glycobiology of platelet-endothelial cell interactions.Blood and lymphatic vessel formation.Platelet CLEC-2 protects against lung injury via effects of its ligand podoplanin on inflammatory alveolar macrophages in the mouse.Platelet immunoreceptor tyrosine-based activation motif (ITAM) and hemITAM signaling and vascular integrity in inflammation and development.Building the drains: the lymphatic vasculature in health and disease.New Concepts and Mechanisms of Platelet Activation Signaling.CLEC-2 is required for development and maintenance of lymph nodes.Emerging Roles for Platelets in Inflammation and Disease.Podoplanin and CLEC-2 drive cerebrovascular patterning and integrity during development.Platelet and Erythrocyte Sources of S1P Are Redundant for Vascular Development and Homeostasis, but Both Rendered Essential After Plasma S1P Depletion in Anaphylactic Shock.Podoplanin-expressing inflammatory macrophages activate murine platelets via CLEC-2.Platelet activation receptor CLEC-2 regulates blood/lymphatic vessel separation by inhibiting proliferation, migration, and tube formation of lymphatic endothelial cells.Mice with a deficiency in CLEC-2 are protected against deep vein thrombosis.Platelets mediate lymphovenous hemostasis to maintain blood-lymphatic separation throughout life.The podoplanin-CLEC-2 axis inhibits inflammation in sepsis.

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CLEC-2 and Syk in the megakaryocytic/platelet lineage are essential for development.

http://www.wikidata.org/entity/Q30514065

description

2011 nî lūn-bûn

@nan

2011 թուականի Դեկտեմբերին հրատարակուած գիտական յօդուած

@hyw

2011 թվականի դեկտեմբերին հրատարակված գիտական հոդված

@hy

2011年の論文

@ja

2011年論文

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2011年論文

@zh-hant

2011年論文

@zh-hk

2011年論文

@zh-mo

2011年論文

@zh-tw

2011年论文

@wuu

name

CLEC-2 and Syk in the megakaryocytic/platelet lineage are essential for development.

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CLEC-2 and Syk in the megakaryocytic/platelet lineage are essential for development.

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type

label

CLEC-2 and Syk in the megakaryocytic/platelet lineage are essential for development.

@ast

CLEC-2 and Syk in the megakaryocytic/platelet lineage are essential for development.

@en

prefLabel

CLEC-2 and Syk in the megakaryocytic/platelet lineage are essential for development.

@ast

CLEC-2 and Syk in the megakaryocytic/platelet lineage are essential for development.

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BLOOD-2011-09-380709

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CLEC-2 and Syk in the megakaryocytic/platelet lineage are essential for development

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Brenda A Finney

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Diego Mourao-Sa

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Edina Schweighoffer

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Kate L Lowe

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Nicholas Smithers

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Stacey A Langan

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Steve Sheardown

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P2860

Drug transport in brain via the cerebrospinal fluid

Molecular characterization of two novel C-type lectin-like receptors, one of which is selectively expressed in human dendritic cells

Isolated lymphatic endothelial cells transduce growth, survival and migratory signals via the VEGF-C/D receptor VEGFR-3

Perinatal lethality and blocked B-cell development in mice lacking the tyrosine kinase Syk

Essential role of Src-family protein tyrosine kinases in NF-kappaB activation during B cell development

Regulation of developmental lymphangiogenesis by Syk(+) leukocytes

Glycoprotein VI but not alpha2beta1 integrin is essential for platelet interaction with collagen.

Platelets play an essential role in separating the blood and lymphatic vasculatures during embryonic angiogenesis

T1 alpha protein is developmentally regulated and expressed by alveolar type I cells, choroid plexus, and ciliary epithelia of adult rats

T1alpha/podoplanin deficiency disrupts normal lymphatic vasculature formation and causes lymphedema

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1747-1756

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10.1182/BLOOD-2011-09-380709

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7

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119

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Caetano Reis e Sousa

Steve P. Watson

Alice Y. Pollitt

Francesca Barone

Victor Tybulewicz

Cecile Bénézech

L Navarro-Nuñez

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2011-12-20T00:00:00Z

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51879900

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22186994

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