Electrophysiological changes precede morphological changes to frontal cortical pyramidal neurons in the rTg4510 mouse model of progressive tauopathy
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Tau Oligomers: The Toxic Player at Synapses in Alzheimer's DiseaseTau-mediated synaptic damage in Alzheimer's diseaseTau pathology induces loss of GABAergic interneurons leading to altered synaptic plasticity and behavioral impairments.Neurofibrillary tangle-bearing neurons are functionally integrated in cortical circuits in vivo.Tau deposition drives neuropathological, inflammatory and behavioral abnormalities independently of neuronal loss in a novel mouse modelHyperphosphorylated tau causes reduced hippocampal CA1 excitability by relocating the axon initial segment.Tau association with synaptic vesicles causes presynaptic dysfunction.Expression of P301L-hTau in mouse MEC induces hippocampus-dependent memory deficit.The intersection of amyloid beta and tau at synapses in Alzheimer's diseaseTau pathology does not affect experience-driven single-neuron and network-wide Arc/Arg3.1 responses.P301L tau expression affects glutamate release and clearance in the hippocampal trisynaptic pathway.Tau causes synapse loss without disrupting calcium homeostasis in the rTg4510 model of tauopathyRescue of tau-induced synaptic transmission pathology by paclitaxel.Neural precursor lineages specify distinct neocortical pyramidal neuron types.Progressive functional impairments of hippocampal neurons in a tauopathy mouse model.Early maturation and distinct tau pathology in induced pluripotent stem cell-derived neurons from patients with MAPT mutations.Age-related decline in white matter integrity in a mouse model of tauopathy: an in vivo diffusion tensor magnetic resonance imaging study.Calcium dysregulation contributes to neurodegeneration in FTLD patient iPSC-derived neuronsThe intersection of amyloid β and tau in glutamatergic synaptic dysfunction and collapse in Alzheimer's disease.The potential role of rho GTPases in Alzheimer's disease pathogenesis.Propagation of Aß pathology: hypotheses, discoveries, and yet unresolved questions from experimental and human brain studies.Altered Intrinsic Pyramidal Neuron Properties and Pathway-Specific Synaptic Dysfunction Underlie Aberrant Hippocampal Network Function in a Mouse Model of Tauopathy.Electrical and Network Neuronal Properties Are Preferentially Disrupted in Dorsal, But Not Ventral, Medial Entorhinal Cortex in a Mouse Model of Tauopathy.Pathological stress granules in Alzheimer's disease.Emergence of early alterations in network oscillations and functional connectivity in a tau seeding mouse model of Alzheimer's disease pathology.Area-Specific Features of Pyramidal Neurons-a Comparative Study in Mouse and Rhesus Monkey.
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P2860
Electrophysiological changes precede morphological changes to frontal cortical pyramidal neurons in the rTg4510 mouse model of progressive tauopathy
description
2012 nî lūn-bûn
@nan
2012 թուականի Սեպտեմբերին հրատարակուած գիտական յօդուած
@hyw
2012 թվականի սեպտեմբերին հրատարակված գիտական հոդված
@hy
2012年の論文
@ja
2012年論文
@yue
2012年論文
@zh-hant
2012年論文
@zh-hk
2012年論文
@zh-mo
2012年論文
@zh-tw
2012年论文
@wuu
name
Electrophysiological changes p ...... model of progressive tauopathy
@ast
Electrophysiological changes p ...... model of progressive tauopathy
@en
type
label
Electrophysiological changes p ...... model of progressive tauopathy
@ast
Electrophysiological changes p ...... model of progressive tauopathy
@en
prefLabel
Electrophysiological changes p ...... model of progressive tauopathy
@ast
Electrophysiological changes p ...... model of progressive tauopathy
@en
P2860
P1476
Electrophysiological changes p ...... model of progressive tauopathy
@en
P2093
Anne B Rocher
Johanna L Crimins
P2860
P2888
P304
P356
10.1007/S00401-012-1038-9
P577
2012-09-14T00:00:00Z
P6179
1050674700