Dynamic steps in receptor tyrosine kinase mediated activation of class IA phosphoinositide 3-kinases (PI3K) captured by H/D exchange (HDX-MS).
about
FBXL2- and PTPL1-mediated degradation of p110-free p85β regulatory subunit controls the PI(3)K signalling cascadeBiophysical methods for the characterization of PTEN/lipid bilayer interactionsUsing hydrogen deuterium exchange mass spectrometry to engineer optimized constructs for crystallization of protein complexes: Case study of PI4KIIIβ with Rab11Engineering of an isolated p110α subunit of PI3Kα permits crystallization and provides a platform for structure-based drug designDiversity-oriented synthesis yields novel multistage antimalarial inhibitorsMolecular determinants of PI3Kγ-mediated activation downstream of G-protein-coupled receptors (GPCRs)Characterization of a tumor-associated activating mutation of the p110β PI 3-kinase.Applications of hydrogen/deuterium exchange MS from 2012 to 2014.Analysis of the ways and methods of signaling pathways in regulating cell cycle of NIH3T3 at transcriptional levelRegulation of PI3K by PKC and MARCKS: Single-Molecule Analysis of a Reconstituted Signaling PathwaySignaling via class IA Phosphoinositide 3-kinases (PI3K) in human, breast-derived cell linesPI3King the right partner: unique interactions and signaling by p110β.Targeting therapeutic liabilities engendered by PIK3R1 mutations for cancer treatment.p110α and p110β isoforms of PI3K signaling: are they two sides of the same coin?PI3K Signaling in Tissue Hyper-Proliferation: From Overgrowth Syndromes to Kidney Cysts.Domain analysis reveals striking functional differences between the regulatory subunits of phosphatidylinositol 3-kinase (PI3K), p85α and p85β.Coincident signals from GPCRs and receptor tyrosine kinases are uniquely transduced by PI3Kβ in myeloid cells.Conformational disruption of PI3Kδ regulation by immunodeficiency mutations in PIK3CD and PIK3R1.Allosteric activation of PI3Kα by oncogenic mutations.Single-Molecule Study Reveals How Receptor and Ras Synergistically Activate PI3Kα and PIP3 Signaling.Molecular Mechanisms of Human Disease Mediated by Oncogenic and Primary Immunodeficiency Mutations in Class IA Phosphoinositide 3-Kinases.Insights into the mechanism of the PIK3CA E545K activating mutation using MD simulations
P2860
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P2860
Dynamic steps in receptor tyrosine kinase mediated activation of class IA phosphoinositide 3-kinases (PI3K) captured by H/D exchange (HDX-MS).
description
2012 nî lūn-bûn
@nan
2012 թուականի Սեպտեմբերին հրատարակուած գիտական յօդուած
@hyw
2012 թվականի սեպտեմբերին հրատարակված գիտական հոդված
@hy
2012年の論文
@ja
2012年論文
@yue
2012年論文
@zh-hant
2012年論文
@zh-hk
2012年論文
@zh-mo
2012年論文
@zh-tw
2012年论文
@wuu
name
Dynamic steps in receptor tyro ...... ured by H/D exchange (HDX-MS).
@ast
Dynamic steps in receptor tyro ...... ured by H/D exchange (HDX-MS).
@en
type
label
Dynamic steps in receptor tyro ...... ured by H/D exchange (HDX-MS).
@ast
Dynamic steps in receptor tyro ...... ured by H/D exchange (HDX-MS).
@en
prefLabel
Dynamic steps in receptor tyro ...... ured by H/D exchange (HDX-MS).
@ast
Dynamic steps in receptor tyro ...... ured by H/D exchange (HDX-MS).
@en
P2860
P1476
Dynamic steps in receptor tyro ...... ured by H/D exchange (HDX-MS).
@en
P2860
P304
P356
10.1016/J.JBIOR.2012.09.005
P577
2012-09-13T00:00:00Z