Drosophila TDP-43 dysfunction in glia and muscle cells cause cytological and behavioural phenotypes that characterize ALS and FTLD
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Aging and Autophagic Function Influences the Progressive Decline of Adult Drosophila BehaviorsTDP-43 Proteinopathy and ALS: Insights into Disease Mechanisms and Therapeutic Targets.Neural Circuits Underlying Fly Larval LocomotionDrosophila lines with mutant and wild type human TDP-43 replacing the endogenous gene reveals phosphorylation and ubiquitination in mutant lines in the absence of viability or lifespan defects.An ALS-mutant TDP-43 neurotoxic peptide adopts an anti-parallel β-structure and induces TDP-43 redistribution.A fruitful endeavor: modeling ALS in the fruit flyInduction of COX-2-PGE2 synthesis by activation of the MAPK/ERK pathway contributes to neuronal death triggered by TDP-43-depleted microglia.VCP-dependent muscle degeneration is linked to defects in a dynamic tubular lysosomal network in vivo.Glial TDP-43 regulates axon wrapping, GluRIIA clustering and fly motility by autonomous and non-autonomous mechanisms.Retrotransposon activation contributes to neurodegeneration in a Drosophila TDP-43 model of ALSTDP-43 causes differential pathology in neuronal versus glial cells in the mouse brain.Glial cells in amyotrophic lateral sclerosisDrosophila as a model to study the role of glia in neurodegeneration.Restoration of motor defects caused by loss of Drosophila TDP-43 by expression of the voltage-gated calcium channel, Cacophony, in central neurons.Synapse Dysfunction of Layer V Pyramidal Neurons Precedes Neurodegeneration in a Mouse Model of TDP-43 Proteinopathies.Reduced TDP-43 Expression Improves Neuronal Activities in a Drosophila Model of Perry Syndrome.Failure to Deliver and Translate-New Insights into RNA Dysregulation in ALS.TDP-43 Proteinopathy: Aggregation and Propagation in the Pathogenesis of Amyotrophic Lateral Sclerosis.EAAT2 and the Molecular Signature of Amyotrophic Lateral Sclerosis.
P2860
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P2860
Drosophila TDP-43 dysfunction in glia and muscle cells cause cytological and behavioural phenotypes that characterize ALS and FTLD
description
2013 nî lūn-bûn
@nan
2013 թուականի Մայիսին հրատարակուած գիտական յօդուած
@hyw
2013 թվականի մայիսին հրատարակված գիտական հոդված
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2013年の論文
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2013年論文
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2013年論文
@zh-hant
2013年論文
@zh-hk
2013年論文
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2013年論文
@zh-tw
2013年论文
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name
Drosophila TDP-43 dysfunction ...... that characterize ALS and FTLD
@ast
Drosophila TDP-43 dysfunction ...... that characterize ALS and FTLD
@en
type
label
Drosophila TDP-43 dysfunction ...... that characterize ALS and FTLD
@ast
Drosophila TDP-43 dysfunction ...... that characterize ALS and FTLD
@en
prefLabel
Drosophila TDP-43 dysfunction ...... that characterize ALS and FTLD
@ast
Drosophila TDP-43 dysfunction ...... that characterize ALS and FTLD
@en
P2093
P2860
P921
P356
P1476
Drosophila TDP-43 dysfunction ...... that characterize ALS and FTLD
@en
P2093
Angelique Di Domenico
Christopher E Shaw
Daniel A Solomon
Danielle C Diaper
Daryl Cheng
Dickon M Humphrey
Fabio A Simoes
Frank Hirth
Luke Lazarou
Max Greenstein
P2860
P304
P356
10.1093/HMG/DDT243
P577
2013-05-31T00:00:00Z