Substrate-selective COX-2 inhibition decreases anxiety via endocannabinoid activation - Wikidata - wikimedia - TriplyDB

Substrate-selective COX-2 inhibition decreases anxiety via endocannabinoid activation

Substrate-selective COX-2 inhibition decreases anxiety via endocannabinoid activation

http://www.wikidata.org/entity/Q30547823

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Towards a personalized treatment in depression: endocannabinoids, inflammation and stress response Parsing the players: 2-arachidonoylglycerol synthesis and degradation in the CNS A lipid gate for the peripheral control of pain 2-arachidonoylglycerol signaling impairs short-term fear extinction.Prediction of the potency of mammalian cyclooxygenase inhibitors with ensemble proteochemometric modeling.Peripheral FAAH and soluble epoxide hydrolase inhibitors are synergistically antinociceptive Ketoconazole inhibits the cellular uptake of anandamide via inhibition of FAAH at pharmacologically relevant concentrations Inhibition of endocannabinoid metabolism by the metabolites of ibuprofen and flurbiprofen Characterisation of (R)-2-(2-Fluorobiphenyl-4-yl)-N-(3-Methylpyridin-2-yl)Propanamide as a Dual Fatty Acid Amide Hydrolase: Cyclooxygenase Inhibitor p21-activated kinase 1 restricts tonic endocannabinoid signaling in the hippocampus Endocannabinoids and striatal function: implications for addiction-related behaviours Peripheral gating of pain signals by endogenous lipid mediators.Substrate-selective COX-2 inhibition as a novel strategy for therapeutic endocannabinoid augmentation Central anandamide deficiency predicts stress-induced anxiety: behavioral reversal through endocannabinoid augmentation.Identification of prostamides, fatty acyl ethanolamines, and their biosynthetic precursors in rabbit cornea.Genetic disruption of 2-arachidonoylglycerol synthesis reveals a key role for endocannabinoid signaling in anxiety modulation.Endocannabinoids and acute pain after total knee arthroplasty.Components of the endocannabinoid and dopamine systems are dysregulated in Huntington's disease: analysis of publicly available microarray datasets.Corticotropin-releasing hormone drives anandamide hydrolysis in the amygdala to promote anxiety.13-Methylarachidonic acid is a positive allosteric modulator of endocannabinoid oxygenation by cyclooxygenase.The fatty acid amide hydrolase inhibitor PF-3845 promotes neuronal survival, attenuates inflammation and improves functional recovery in mice with traumatic brain injury.4'-O-methylhonokiol increases levels of 2-arachidonoyl glycerol in mouse brain via selective inhibition of its COX-2-mediated oxygenation.Neurobiological Interactions Between Stress and the Endocannabinoid System.The Role of Endocannabinoid Signaling in Cortical Inhibitory Neuron Dysfunction in Schizophrenia.Sustained glucocorticoid exposure recruits cortico-limbic CRH signaling to modulate endocannabinoid function.Cyclooxygenase-2 inhibition reduces stress-induced affective pathology.Staged anticonvulsant screening for chronic epilepsy.Endocannabinoids and neuropathic pain: focus on neuron-glia and endocannabinoid-neurotrophin interactions.Prostamide F(2) α receptor antagonism combined with inhibition of FAAH may block the pro-inflammatory mediators formed following selective FAAH inhibition The cannabinoid system and pain.An Introduction to the Endogenous Cannabinoid System.Functional Redundancy Between Canonical Endocannabinoid Signaling Systems in the Modulation of Anxiety.Modulation of Glucagon-like Peptide-1 (GLP-1) Potency by Endocannabinoid-like Lipids Represents a Novel Mode of Regulating GLP-1 Receptor Signaling.Upregulation of fatty acid amide hydrolase in the dorsal periaqueductal gray is associated with neuropathic pain and reduced heart rate in rats.Cyclooxygenase Inhibition: Pain, Inflammation, and the Cardiovascular System.The endocannabinoid system as a target for novel anxiolytic drugs.Metabolism of the Endocannabinoid Anandamide: Open Questions after 25 Years.Integrating Endocannabinoid Signaling and Cannabinoids into the Biology and Treatment of Posttraumatic Stress Disorder.Regulation of human glioblastoma cell death by combined treatment of cannabidiol, γ-radiation and small molecule inhibitors of cell signaling pathways.Chronic administration of parecoxib exerts anxiolytic-like and memory enhancing effects and modulates synaptophysin expression in mice.

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Substrate-selective COX-2 inhibition decreases anxiety via endocannabinoid activation

http://www.wikidata.org/entity/Q30547823

description

2013 nî lūn-bûn

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2013 թուականի Օգոստոսին հրատարակուած գիտական յօդուած

@hyw

2013 թվականի օգոստոսին հրատարակված գիտական հոդված

@hy

2013年の論文

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2013年論文

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2013年論文

@zh-hant

2013年論文

@zh-hk

2013年論文

@zh-mo

2013年論文

@zh-tw

2013年论文

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name

Substrate-selective COX-2 inhibition decreases anxiety via endocannabinoid activation

@ast

Substrate-selective COX-2 inhibition decreases anxiety via endocannabinoid activation

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type

label

Substrate-selective COX-2 inhibition decreases anxiety via endocannabinoid activation

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Substrate-selective COX-2 inhibition decreases anxiety via endocannabinoid activation

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prefLabel

Substrate-selective COX-2 inhibition decreases anxiety via endocannabinoid activation

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Substrate-selective COX-2 inhibition decreases anxiety via endocannabinoid activation

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Nature Neuroscience

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Substrate-selective COX-2 inhibition decreases anxiety via endocannabinoid activation

@en

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Daniel J Hermanson

http://www.w3.org/2001/XMLSchema#string

Jeffrey Reese

http://www.w3.org/2001/XMLSchema#string

Lawrence J Marnett

http://www.w3.org/2001/XMLSchema#string

Naoko Brown

http://www.w3.org/2001/XMLSchema#string

Nolan D Hartley

http://www.w3.org/2001/XMLSchema#string

Phillip J Kingsley

http://www.w3.org/2001/XMLSchema#string

Sachin Patel

http://www.w3.org/2001/XMLSchema#string

P2860

Selective blockade of 2-arachidonoylglycerol hydrolysis produces cannabinoid behavioral effects

A comprehensive profile of brain enzymes that hydrolyze the endocannabinoid 2-arachidonoylglycerol

Differential sensitivity and mechanism of inhibition of COX-2 oxygenation of arachidonic acid and 2-arachidonoylglycerol by ibuprofen and mefenamic acid

R-flurbiprofen reduces neuropathic pain in rodents by restoring endogenous cannabinoids

Discovery and Characterization of a Highly Selective FAAH Inhibitor that Reduces Inflammatory Pain

(R)-Profens are substrate-selective inhibitors of endocannabinoid oxygenation by COX-2

Molecular characterization of an enzyme that degrades neuromodulatory fatty-acid amides

Enzymatic pathways that regulate endocannabinoid signaling in the nervous system

The molecular logic of endocannabinoid signalling

Modulation of anxiety through blockade of anandamide hydrolysis

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1291-1298

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10.1038/NN.3480

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P433

9

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P478

16

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Joyonna C Gamble-George

Roger J. Colbran

Brian C Shonesy

P577

2013-08-04T00:00:00Z

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255177705

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23912944

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endocannabinoids

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3788575

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