Multivariate analysis of cell culture bioprocess data--lactate consumption as process indicator.
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Fingerprint detection and process prediction by multivariate analysis of fed-batch monoclonal antibody cell culture data.Cyclin and DNA distributed cell cycle model for GS-NS0 cells.Multiplicity of steady states in glycolysis and shift of metabolic state in cultured mammalian cells.Advanced multivariate data analysis to determine the root cause of trisulfide bond formation in a novel antibody-peptide fusionEstablishment of a CpG island microarray for analyses of genome-wide DNA methylation in Chinese hamster ovary cells.Metabolic flux rewiring in mammalian cell cultures.Low glucose concentrations within typical industrial operating conditions have minimal effect on the transcriptome of recombinant CHO cells.Enhanced process understanding and multivariate prediction of the relationship between cell culture process and monoclonal antibody quality.Pilot-scale verification of maximum tolerable hydrodynamic stress for mammalian cell culture.Mechanism for multiplicity of steady states with distinct cell concentration in continuous culture of mammalian cells.Effects of copper on CHO cells: cellular requirements and product quality considerations.Application of bioreactor design principles and multivariate analysis for development of cell culture scale down models.A framework for the systematic design of fed-batch strategies in mammalian cell culture.Progress toward forecasting product quality and quantity of mammalian cell culture processes by performance-based modeling.Effects of copper on CHO cells: insights from gene expression analyses.Application of multivariate analysis and mass transfer principles for refinement of a 3-L bioreactor scale-down model--when shake flasks mimic 15,000-L bioreactors better.Metabolic Control in Mammalian Fed-Batch Cell Cultures for Reduced Lactic Acid Accumulation and Improved Process RobustnessWhole-cell Escherichia coli lactate biosensor for monitoring mammalian cell cultures during biopharmaceutical production.Development of a scale down cell culture model using multivariate analysis as a qualification tool.First CpG island microarray for genome-wide analyses of DNA methylation in Chinese hamster ovary cells: new insights into the epigenetic answer to butyrate treatment.The emerging role of systems biology for engineering protein production in CHO cells.A practical approach in bioreactor scale-up and process transfer using a combination of constant P/V and vvm as the criterion.Metabolic phenotyping of CHO cells varying in cellular biomass accumulation and maintenance during fed-batch culture.Kinetic Modeling of Mammalian Cell Culture Bioprocessing: The Quest to Advance Biomanufacturing.A robust feeding strategy to maintain set-point glucose in mammalian fed-batch cultures when input parameters have a large error.Combining metabolic and process engineering strategies to improve recombinant glycoprotein production and quality.A Simple Method to Reduce both Lactic Acid and Ammonium Production in Industrial Animal Cell Culture.Lactate and glucose concomitant consumption as a self-regulated pH detoxification mechanism in HEK293 cell cultures.Closed loop control of lactate concentration in mammalian cell culture by Raman spectroscopy leads to improved cell density, viability, and biopharmaceutical protein production.
P2860
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P2860
Multivariate analysis of cell culture bioprocess data--lactate consumption as process indicator.
description
2012 nî lūn-bûn
@nan
2012 թուականի Սեպտեմբերին հրատարակուած գիտական յօդուած
@hyw
2012 թվականի սեպտեմբերին հրատարակված գիտական հոդված
@hy
2012年の論文
@ja
2012年論文
@yue
2012年論文
@zh-hant
2012年論文
@zh-hk
2012年論文
@zh-mo
2012年論文
@zh-tw
2012年论文
@wuu
name
Multivariate analysis of cell ...... sumption as process indicator.
@ast
Multivariate analysis of cell ...... sumption as process indicator.
@en
type
label
Multivariate analysis of cell ...... sumption as process indicator.
@ast
Multivariate analysis of cell ...... sumption as process indicator.
@en
prefLabel
Multivariate analysis of cell ...... sumption as process indicator.
@ast
Multivariate analysis of cell ...... sumption as process indicator.
@en
P2093
P1476
Multivariate analysis of cell ...... sumption as process indicator.
@en
P2093
George Karypis
Keri Mills
Kevin Johnson
Luciano Pollastrini
Santosh Kabbur
Wei-Shou Hu
P304
P356
10.1016/J.JBIOTEC.2012.08.021
P577
2012-09-10T00:00:00Z