Pharmacological inhibition of mTORC1 suppresses anatomical, cellular, and behavioral abnormalities in neural-specific Pten knock-out mice - Wikidata - wikimedia - TriplyDB

Pharmacological inhibition of mTORC1 suppresses anatomical, cellular, and behavioral abnormalities in neural-specific Pten knock-out mice

Pharmacological inhibition of mTORC1 suppresses anatomical, cellular, and behavioral abnormalities in neural-specific Pten knock-out mice

http://www.wikidata.org/entity/Q30569745

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Neuropathology and animal models of autism: genetic and environmental factors Mitochondrial dysfunction in Pten haplo-insufficient mice with social deficits and repetitive behavior: interplay between Pten and p53 Phosphorylation of the actin binding protein Drebrin at S647 is regulated by neuronal activity and PTEN Ribosomal Protein S6 Phosphorylation in the Nervous System: From Regulation to Function Behavioral phenotypes of genetic mouse models of autism.Characterizing autism spectrum disorders by key biochemical pathways.Dysregulation of Mammalian Target of Rapamycin Signaling in Mouse Models of Autism Roles of mTOR Signaling in Brain Development Balancing Proliferation and Connectivity in PTEN-associated Autism Spectrum Disorder The neurology of mTOR PTEN: A master regulator of neuronal structure, function, and plasticity Networking in autism: leveraging genetic, biomarker and model system findings in the search for new treatments The molecular basis of cognitive deficits in pervasive developmental disorders Subcellular targeting and dynamic regulation of PTEN: implications for neuronal cells and neurological disorders Finding a better drug for epilepsy: the mTOR pathway as an antiepileptogenic target mTOR inhibition suppresses established epilepsy in a mouse model of cortical dysplasia.In vivo AAV1 transduction with hRheb(S16H) protects hippocampal neurons by BDNF production The parvalbumin/somatostatin ratio is increased in Pten mutant mice and by human PTEN ASD alleles.Negative allosteric modulation of the mGluR5 receptor reduces repetitive behaviors and rescues social deficits in mouse models of autism.Genetic aspects of autism spectrum disorders: insights from animal models Advancing the understanding of autism disease mechanisms through genetics A Subset of Autism-Associated Genes Regulate the Structural Stability of Neurons.Translational Mouse Models of Autism: Advancing Toward Pharmacological Therapeutics.Neuronal connectivity as a convergent target of gene × environment interactions that confer risk for Autism Spectrum Disorders DISC1 regulates new neuron development in the adult brain via modulation of AKT-mTOR signaling through KIAA1212 Pten knockdown in vivo increases excitatory drive onto dentate granule cells Autism-related deficits via dysregulated eIF4E-dependent translational control.Dendritic spine pathology in neuropsychiatric disorders Behavioural phenotyping assays for mouse models of autism Automated three-chambered social approach task for mice Comprehensive behavioral analysis of RNG105 (Caprin1) heterozygous mice: Reduced social interaction and attenuated response to novelty PTEN knockdown alters dendritic spine/protrusion morphology, not density Influence of stimulant-induced hyperactivity on social approach in the BTBR mouse model of autism PTEN regulation of local and long-range connections in mouse auditory cortex.Translational animal models of autism and neurodevelopmental disorders.Mouse models of autism: testing hypotheses about molecular mechanisms.Annual Research Review: Transgenic mouse models of childhood-onset psychiatric disorders.Pharmacological inhibition of the mammalian target of rapamycin pathway suppresses acquired epilepsy.Tsc2 gene inactivation causes a more severe epilepsy phenotype than Tsc1 inactivation in a mouse model of tuberous sclerosis complex.A pulse rapamycin therapy for infantile spasms and associated cognitive decline.

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P2860

Pharmacological inhibition of mTORC1 suppresses anatomical, cellular, and behavioral abnormalities in neural-specific Pten knock-out mice

http://www.wikidata.org/entity/Q30569745

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2009 nî lūn-bûn

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2009 թուականի Փետրուարին հրատարակուած գիտական յօդուած

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2009 թվականի փետրվարին հրատարակված գիտական հոդված

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2009年の論文

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2009年論文

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2009年論文

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2009年論文

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2009年論文

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2009年論文

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Pharmacological inhibition of ...... l-specific Pten knock-out mice

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Pharmacological inhibition of ...... l-specific Pten knock-out mice

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JNEUROSCI.5685-08.2009

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Journal of Neuroscience

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Pharmacological inhibition of ...... l-specific Pten knock-out mice

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Chang-Hyuk Kwon

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Christopher Sinton

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Jacqueline Blundell

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Jing Zhou

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Luis F Parada

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Shiori Ogawa

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Wei Zhang

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P2860

Mapping Early Brain Development in Autism

Phosphorylation and regulation of Akt/PKB by the rictor-mTOR complex

Reversal of learning deficits in a Tsc2+/- mouse model of tuberous sclerosis

Subset of individuals with autism spectrum disorders and extreme macrocephaly associated with germline PTEN tumour suppressor gene mutations

Generalized lacZ expression with the ROSA26 Cre reporter strain

TSC2 is phosphorylated and inhibited by Akt and suppresses mTOR signalling

Targets for cell cycle arrest by the immunosuppressant rapamycin in yeast

Prolonged rapamycin treatment inhibits mTORC2 assembly and Akt/PKB

A mouse model of tuberous sclerosis: neuronal loss of Tsc1 causes dysplastic and ectopic neurons, reduced myelination, seizure activity, and limited survival

Pten regulates neuronal arborization and social interaction in mice.

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10.1523/JNEUROSCI.5685-08.2009

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