A paired RNAi and RabGAP overexpression screen identifies Rab11 as a regulator of β-amyloid production. - Wikidata - wikimedia - TriplyDB

A paired RNAi and RabGAP overexpression screen identifies Rab11 as a regulator of β-amyloid production.

A paired RNAi and RabGAP overexpression screen identifies Rab11 as a regulator of β-amyloid production.

http://www.wikidata.org/entity/Q30577278

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Decreased CALM expression reduces Aβ42 to total Aβ ratio through clathrin-mediated endocytosis of γ-secretase G Protein-Coupled Receptors (GPCRs) in Alzheimer's Disease: A Focus on BACE1 Related GPCRs β-Amyloid: the key peptide in the pathogenesis of Alzheimer's disease The endosomal-lysosomal system: from acidification and cargo sorting to neurodegeneration Early etiology of Alzheimer's disease: tipping the balance toward autophagy or endosomal dysfunction?Physiological Functions of the β-Site Amyloid Precursor Protein Cleaving Enzyme 1 and 2 Axonal BACE1 dynamics and targeting in hippocampal neurons: a role for Rab11 GTPase Function, therapeutic potential and cell biology of BACE proteases: current status and future prospects.Dysregulation of protein trafficking in neurodegeneration.Insulin resistance in Alzheimer's disease.Evidence of a novel mechanism for partial γ-secretase inhibition induced paradoxical increase in secreted amyloid β protein Significance of transcytosis in Alzheimer's disease: BACE1 takes the scenic route to axons.Inhibiting BACE1 to reverse synaptic dysfunctions in Alzheimer's disease.A function for EHD family proteins in unidirectional retrograde dendritic transport of BACE1 and Alzheimer's disease Aβ production.The role of rab proteins in neuronal cells and in the trafficking of neurotrophin receptors.Rab11 in disease progression.Rab21, a Novel PS1 Interactor, Regulates γ-Secretase Activity via PS1 Subcellular Distribution.Small RNA sequencing revealed dysregulated piRNAs in Alzheimer's disease and their probable role in pathogenesis.Retromer and Rab2-dependent trafficking mediate PS1 degradation by proteasomes in endocytic disturbance.Endo-lysosomal and autophagic dysfunction: a driving factor in Alzheimer's disease?Exosomes and the Prion Protein: More than One Truth.Defective Transcytosis of APP and Lipoproteins in Human iPSC-Derived Neurons with Familial Alzheimer's Disease Mutations.Identification of Biomarkers Associated With Alzheimer's Disease by Bioinformatics Analysis.Genome-wide RNAi screen reveals a role for multipass membrane proteins in endosome-to-golgi retrieval.Altered protein phosphorylation as a resource for potential AD biomarkers.Derailed intraneuronal signalling drives pathogenesis in sporadic and familial Alzheimer's disease.Linkage, whole genome sequence, and biological data implicate variants in RAB10 in Alzheimer's disease resilience.GGA1 regulates signal-dependent sorting of BACE1 to recycling endosomes, which moderates Aβ production.The physical approximation of APP and BACE-1: A key event in alzheimer's disease pathogenesis.miR-186 in Alzheimer's disease: a big hope for a small RNA?Par3 and aPKC regulate BACE1 endosome-to-TGN trafficking through PACS1.Alzheimer disease: modeling an Aβ-centered biological network.ADAM10 and BACE1 are localized to synaptic vesicles.Bin1 and CD2AP polarise the endocytic generation of beta-amyloid.Overexpression of SNX3 Decreases Amyloid-β Peptide Production by Reducing Internalization of Amyloid Precursor Protein.Surface Trafficking of APP and BACE in Live Cells.Isoprenoids and protein prenylation: implications in the pathogenesis and therapeutic intervention of Alzheimer's disease.TMEM30A is a candidate interacting partner for the β-carboxyl-terminal fragment of amyloid-β precursor protein in endosomes

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A paired RNAi and RabGAP overexpression screen identifies Rab11 as a regulator of β-amyloid production.

http://www.wikidata.org/entity/Q30577278

description

2013 nî lūn-bûn

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2013 թուականի Դեկտեմբերին հրատարակուած գիտական յօդուած

@hyw

2013 թվականի դեկտեմբերին հրատարակված գիտական հոդված

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2013年の論文

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2013年論文

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2013年論文

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2013年論文

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2013年論文

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2013年論文

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2013年论文

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name

A paired RNAi and RabGAP overe ...... lator of β-amyloid production.

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A paired RNAi and RabGAP overe ...... lator of β-amyloid production.

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type

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A paired RNAi and RabGAP overe ...... lator of β-amyloid production.

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A paired RNAi and RabGAP overe ...... lator of β-amyloid production.

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prefLabel

A paired RNAi and RabGAP overe ...... lator of β-amyloid production.

@ast

A paired RNAi and RabGAP overe ...... lator of β-amyloid production.

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A paired RNAi and RabGAP overe ...... lator of β-amyloid production.

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AESG

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Virginie Buggia-Prévot

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P2860

Beta-secretase cleavage of Alzheimer's amyloid precursor protein by the transmembrane aspartic protease BACE

A mutation in APP protects against Alzheimer’s disease and age-related cognitive decline

Alzheimer mechanisms and therapeutic strategies

Structural basis for Rab11-dependent membrane recruitment of a family of Rab11-interacting protein 3 (FIP3)/Arfophilin-1

Functional dissection of Rab GTPases involved in primary cilium formation

TBC1D14 regulates autophagosome formation via Rab11- and ULK1-positive recycling endosomes

Neuronal sorting protein-related receptor sorLA/LR11 regulates processing of the amyloid precursor protein.

Rab27a and Rab27b control different steps of the exosome secretion pathway

The Rab GTPase family

The neuronal sortilin-related receptor SORL1 is genetically associated with Alzheimer disease

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Lawrence Rajendran

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