Reduced cognition in Syngap1 mutants is caused by isolated damage within developing forebrain excitatory neurons - Wikidata - wikimedia - TriplyDB

Reduced cognition in Syngap1 mutants is caused by isolated damage within developing forebrain excitatory neurons

Reduced cognition in Syngap1 mutants is caused by isolated damage within developing forebrain excitatory neurons

http://www.wikidata.org/entity/Q30584376

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SYNGAP1: Mind the Gap Rapid dispersion of SynGAP from synaptic spines triggers AMPA receptor insertion and spine enlargement during LTP.A Subset of Autism-Associated Genes Regulate the Structural Stability of Neurons.BRaf signaling principles unveiled by large-scale human mutation analysis with a rapid lentivirus-based gene replacement method.Prioritizing the development of mouse models for childhood brain disorders Decrease of SYNGAP1 in GABAergic cells impairs inhibitory synapse connectivity, synaptic inhibition and cognitive function.Epilepsy and Autism.Syngap1 haploinsufficiency damages a postnatal critical period of pyramidal cell structural maturation linked to cortical circuit assembly Input-specific regulation of hippocampal circuit maturation by non-muscle myosin IIB.Convergence of Hippocampal Pathophysiology in Syngap+/- and Fmr1-/y Mice.Pathway-driven discovery of epilepsy genes.Single-Gene Determinants of Epilepsy Comorbidity.Genetic and Pharmacological Reversibility of Phenotypes in Mouse Models of Autism Spectrum Disorder.Neurobiological bases of autism-epilepsy comorbidity: a focus on excitation/inhibition imbalance.Autism spectrum disorder: neuropathology and animal models.Disrupted circuits in mouse models of autism spectrum disorder and intellectual disability.Anchoring high concentrations of SynGAP at postsynaptic densities via liquid-liquid phase separation.DNA Methylation Signatures of Early Childhood Malnutrition Associated With Impairments in Attention and Cognition.The first international conference on SYNGAP1-related brain disorders: a stakeholder meeting of families, researchers, clinicians, and regulators.Species-conserved SYNGAP1 phenotypes associated with neurodevelopmental disorders.Synaptic Disorders

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Reduced cognition in Syngap1 mutants is caused by isolated damage within developing forebrain excitatory neurons

http://www.wikidata.org/entity/Q30584376

description

2014 nî lūn-bûn

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2014 թուականի Յունիսին հրատարակուած գիտական յօդուած

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2014 թվականի հունիսին հրատարակված գիտական հոդված

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2014年の論文

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2014年論文

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2014年論文

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2014年論文

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2014年論文

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2014年論文

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2014年论文

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name

Reduced cognition in Syngap1 m ...... g forebrain excitatory neurons

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Reduced cognition in Syngap1 m ...... g forebrain excitatory neurons

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type

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Reduced cognition in Syngap1 m ...... g forebrain excitatory neurons

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Reduced cognition in Syngap1 m ...... g forebrain excitatory neurons

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prefLabel

Reduced cognition in Syngap1 m ...... g forebrain excitatory neurons

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Reduced cognition in Syngap1 m ...... g forebrain excitatory neurons

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J.NEURON.2014.05.015

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Reduced cognition in Syngap1 m ...... g forebrain excitatory neurons

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Alex H Babyan

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Camilo Rojas

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Courtney A Miller

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Emin D Ozkan

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Enikö A Kramár

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Gary Lynch

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Gavin Rumbaugh

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Rocco Lucero

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Ron R Seese

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Thomas K Creson

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P2860

SynGAP regulates synaptic strength and mitogen-activated protein kinases in cultured neurons

Targeted resequencing in epileptic encephalopathies identifies de novo mutations in CHD2 and SYNGAP1.

Pathogenic SYNGAP1 mutations impair cognitive development by disrupting maturation of dendritic spine synapses.

Mutations in SYNGAP1 in autosomal nonsyndromic mental retardation

A developmental switch in the response of DRG neurons to ETS transcription factor signaling

The role of synaptic GTPase-activating protein in neuronal development and synaptic plasticity

SynGAP: a synaptic RasGAP that associates with the PSD-95/SAP90 protein family

A synaptic Ras-GTPase activating protein (p135 SynGAP) inhibited by CaM kinase II

Range of genetic mutations associated with severe non-syndromic sporadic intellectual disability: an exome sequencing study

Dendritic spine geometry is critical for AMPA receptor expression in hippocampal CA1 pyramidal neurons

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scholarly article

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10.1016/J.NEURON.2014.05.015

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6

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Jeffrey L. Noebels

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2014-06-01T00:00:00Z

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24945774

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