Increasing microtubule acetylation rescues axonal transport and locomotor deficits caused by LRRK2 Roc-COR domain mutations. - Wikidata - wikimedia - TriplyDB

Increasing microtubule acetylation rescues axonal transport and locomotor deficits caused by LRRK2 Roc-COR domain mutations.

Increasing microtubule acetylation rescues axonal transport and locomotor deficits caused by LRRK2 Roc-COR domain mutations.

http://www.wikidata.org/entity/Q30596172

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Neurodegeneration and microtubule dynamics: death by a thousand cuts HDAC6 Inhibitors Rescued the Defective Axonal Mitochondrial Movement in Motor Neurons Derived from the Induced Pluripotent Stem Cells of Peripheral Neuropathy Patients with HSPB1 Mutation Epothilone D prevents binge methamphetamine-mediated loss of striatal dopaminergic markers.Development of Improved HDAC6 Inhibitors as Pharmacological Therapy for Axonal Charcot-Marie-Tooth Disease Phosphatidylserine improves axonal transport by inhibition of HDAC and has potential in treatment of neurodegenerative diseases.Role of LRRK2 in the regulation of dopamine receptor trafficking Tubulin acetylation: responsible enzymes, biological functions and human diseases.The Parkinson's Disease-Associated Mutation LRRK2-G2019S Impairs Synaptic Plasticity in Mouse Hippocampus.Understanding the susceptibility of dopamine neurons to mitochondrial stressors in Parkinson's disease.Reducing Lissencephaly-1 levels augments mitochondrial transport and has a protective effect in adult Drosophila neurons.Mechanism of microtubule lumen entry for the α-tubulin acetyltransferase enzyme αTAT1.Back to the tubule: microtubule dynamics in Parkinson's disease.Contribution of Neuroepigenetics to Huntington's Disease.Microtubule-Targeting Agents Enter the Central Nervous System (CNS): Double-edged Swords for Treating CNS Injury and Disease.Cellular processes associated with LRRK2 function and dysfunction LRRK2 Kinase Inhibition as a Therapeutic Strategy for Parkinson's Disease, Where Do We Stand?Pyridine Dinucleotides from Molecules to Man.LRRK2 at the Crossroad Between Autophagy and Microtubule Trafficking: Insights into Parkinson's Disease.Tissue-specific transcription of the neuronal gene Lim3 affects Drosophila melanogaster lifespan and locomotion.GTP binding regulates cellular localization of Parkinson's disease-associated LRRK2.Endolysosomal dysfunction in Parkinson's disease: Recent developments and future challenges.An update on potential therapeutic strategies for Parkinson's disease based on pathogenic mechanisms.Sirtuins as modifiers of Parkinson's disease pathology.Mitochondrial Metabolism Regulates Microtubule Acetylome and Autophagy Trough Sirtuin-2: Impact for Parkinson's Disease.Microtubule Destabilization Paves the Way to Parkinson's Disease.Neurobiology of axonal transport defects in motor neuron diseases: Opportunities for translational research?Understanding the GTPase Activity of LRRK2: Regulation, Function, and Neurotoxicity.Models of LRRK2-Associated Parkinson's Disease.Targeting LRRK2 in Parkinson's disease: an update on recent developments.Axonal transport defects are a common phenotype in Drosophila models of ALS.SIRT2 regulates nuclear envelope reassembly through ANKLE2 deacetylation.68 and FX2149 Attenuate Mutant LRRK2-R1441C-Induced Neural Transport Impairment.HDAC6 inhibition reverses axonal transport defects in motor neurons derived from FUS-ALS patients.Effects of Paclitaxel and Eribulin in Mouse Sciatic Nerve: A Microtubule-Based Rationale for the Differential Induction of Chemotherapy-Induced Peripheral Neuropathy.Microtubule-Targeting Agents Eribulin and Paclitaxel Differentially Affect Neuronal Cell Bodies in Chemotherapy-Induced Peripheral Neuropathy.The Upshot of LRRK2 Inhibition to Parkinson's Disease Paradigm.Liraglutide activates autophagy via GLP-1R to improve functional recovery after spinal cord injury.Neuron and microglia/macrophage-derived FGF10 activate neuronal FGFR2/PI3K/Akt signaling and inhibit microglia/macrophages TLR4/NF-κB-dependent neuroinflammation to improve functional recovery after spinal cord injury.Mitochondria: A Common Target for Genetic Mutations and Environmental Toxicants in Parkinson's Disease.G2019S LRRK2 enhances the neuronal transmission of tau in the mouse brain.

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Increasing microtubule acetylation rescues axonal transport and locomotor deficits caused by LRRK2 Roc-COR domain mutations.

http://www.wikidata.org/entity/Q30596172

description

2014 nî lūn-bûn

@nan

2014 թուականի Հոկտեմբերին հրատարակուած գիտական յօդուած

@hyw

2014 թվականի հոտեմբերին հրատարակված գիտական հոդված

@hy

2014年の論文

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2014年論文

@yue

2014年論文

@zh-hant

2014年論文

@zh-hk

2014年論文

@zh-mo

2014年論文

@zh-tw

2014年论文

@wuu

name

Increasing microtubule acetyla ...... RRK2 Roc-COR domain mutations.

@ast

Increasing microtubule acetyla ...... RRK2 Roc-COR domain mutations.

@en

type

label

Increasing microtubule acetyla ...... RRK2 Roc-COR domain mutations.

@ast

Increasing microtubule acetyla ...... RRK2 Roc-COR domain mutations.

@en

prefLabel

Increasing microtubule acetyla ...... RRK2 Roc-COR domain mutations.

@ast

Increasing microtubule acetyla ...... RRK2 Roc-COR domain mutations.

@en

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Nature Communications

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Increasing microtubule acetyla ...... RRK2 Roc-COR domain mutations.

@en

P2093

Annekathrin Moller

http://www.w3.org/2001/XMLSchema#string

Gary Shaw

http://www.w3.org/2001/XMLSchema#string

Matthew Oswald

http://www.w3.org/2001/XMLSchema#string

Nicholas Brookes-Hocking

http://www.w3.org/2001/XMLSchema#string

Rosa M Sancho

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Vinay K Godena

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P2860

Parkinson's disease-associated kinase PINK1 regulates Miro protein level and axonal transport of mitochondria

Parkinson's disease-associated mutations in leucine-rich repeat kinase 2 augment kinase activity

PINK1 and Parkin target Miro for phosphorylation and degradation to arrest mitochondrial motility

HDAC6 is a microtubule-associated deacetylase

Direct binding of alpha-actinin enhances TRPP3 channel activity

MEC-17 is an alpha-tubulin acetyltransferase

The R1441C mutation of LRRK2 disrupts GTP hydrolysis

Insight into the mode of action of the LRRK2 Y1699C pathogenic mutant

Mutations in the parkin gene cause autosomal recessive juvenile parkinsonism

A direct interaction between leucine-rich repeat kinase 2 and specific β-tubulin isoforms regulates tubulin acetylation

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10.1038/NCOMMS6245

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5

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Alexander J. Whitworth

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2014-10-15T00:00:00Z

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266946031

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1006619181

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25316291

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4208097

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