Formation of α-synuclein Lewy neurite-like aggregates in axons impedes the transport of distinct endosomes. - Wikidata - wikimedia - TriplyDB

Formation of α-synuclein Lewy neurite-like aggregates in axons impedes the transport of distinct endosomes.

Formation of α-synuclein Lewy neurite-like aggregates in axons impedes the transport of distinct endosomes.

http://www.wikidata.org/entity/Q30607522

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Alpha-synuclein Toxicity in the Early Secretory Pathway: How It Drives Neurodegeneration in Parkinsons Disease Immunomodulators as Therapeutic Agents in Mitigating the Progression of Parkinson's Disease Autophagosome dynamics in neurodegeneration at a glance Retrograde transport of TrkB-containing autophagosomes via the adaptor AP-2 mediates neuronal complexity and prevents neurodegeneration Synuclein impairs trafficking and signaling of BDNF in a mouse model of Parkinson's disease.α-Synuclein binds to the ER-mitochondria tethering protein VAPB to disrupt Ca2+ homeostasis and mitochondrial ATP production The Protein Complex of Neurodegeneration-related Phosphoinositide Phosphatase Sac3 and ArPIKfyve Binds the Lewy Body-associated Synphilin-1, Preventing Its Aggregation.Bent out of shape: α-Synuclein misfolding and the convergence of pathogenic pathways in Parkinson's disease.G2019S-LRRK2 Expression Augments α-Synuclein Sequestration into Inclusions in Neurons.Reducing Endogenous α-Synuclein Mitigates the Degeneration of Selective Neuronal Populations in an Alzheimer's Disease Transgenic Mouse Model.Novel antibodies to phosphorylated α-synuclein serine 129 and NFL serine 473 demonstrate the close molecular homology of these epitopes Compartment-Dependent Degradation of Mutant Huntingtin Accounts for Its Preferential Accumulation in Neuronal Processes Neuropathological Staging of Brain Pathology in Sporadic Parkinson's disease: Separating the Wheat from the Chaff.Glial Cell Line-Derived Neurotrophic Factor Gene Delivery in Parkinson's Disease: A Delicate Balance between Neuroprotection, Trophic Effects, and Unwanted Compensatory Mechanisms.Review: Parkinson's disease: from synaptic loss to connectome dysfunction.α-Synuclein transfer between neurons and astrocytes indicates that astrocytes play a role in degradation rather than in spreading.Trophic factors for Parkinson's disease: To live or let die.Mesenchymal Stem Cells Stabilize Axonal Transports for Autophagic Clearance of α-Synuclein in Parkinsonian Models.Amyotrophic lateral sclerosis-like superoxide dismutase 1 proteinopathy is associated with neuronal loss in Parkinson's disease brain.Cellular models for Parkinson's disease.How can rAAV-α-synuclein and the fibril α-synuclein models advance our understanding of Parkinson's disease?Novel conformation-selective alpha-synuclein antibodies raised against different in vitro fibril forms show distinct patterns of Lewy pathology in Parkinson's disease.Internalization, axonal transport and release of fibrillar forms of alpha-synuclein.Potential Pathways of Abnormal Tau and α-Synuclein Dissemination in Sporadic Alzheimer's and Parkinson's Diseases.HIV-1 Vpr disrupts mitochondria axonal transport and accelerates neuronal aging.Defects in trafficking bridge Parkinson's disease pathology and genetics.Repairing the Aged Parkinsonian Striatum: Lessons from the Lab and Clinic.Treatments and compositions targeting α-synuclein: a patent review (2010-2016).Early Degeneration of Both Dopaminergic and Serotonergic Axons - A Common Mechanism in Parkinson's Disease.Integral Characterization of Defective BDNF/TrkB Signalling in Neurological and Psychiatric Disorders Leads the Way to New Therapies.Rab7 may be a novel therapeutic target for neurologic diseases as a key regulator in autophagy.αSynuclein control of mitochondrial homeostasis in human-derived neurons is disrupted by mutations associated with Parkinson's disease.Current concepts and controversies in the pathogenesis of Parkinson's disease dementia and Dementia with Lewy Bodies.Mitochondrial dynamics in Parkinson's disease: a role for α-synuclein?Autophagy impairment in Parkinson's disease.Synaptic phosphorylated α-synuclein in dementia with Lewy bodies.Convergent pathways in Parkinson's disease.Critical appraisal of pathology transmission in the α-synuclein fibril model of Lewy body disorders.TrkB neurotrophic activities are blocked by α-synuclein, triggering dopaminergic cell death in Parkinson's disease.Effect of Intrastriatal 6-OHDA Lesions on Extrastriatal Brain Structures in the Mouse.

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P2860

Formation of α-synuclein Lewy neurite-like aggregates in axons impedes the transport of distinct endosomes.

http://www.wikidata.org/entity/Q30607522

description

2014 nî lūn-bûn

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2014 թուականի Հոկտեմբերին հրատարակուած գիտական յօդուած

@hyw

2014 թվականի հոտեմբերին հրատարակված գիտական հոդված

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2014年の論文

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2014年論文

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2014年論文

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2014年論文

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2014年論文

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2014年論文

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2014年论文

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name

Formation of α-synuclein Lewy ...... ansport of distinct endosomes.

@ast

Formation of α-synuclein Lewy ...... ansport of distinct endosomes.

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type

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Formation of α-synuclein Lewy ...... ansport of distinct endosomes.

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Formation of α-synuclein Lewy ...... ansport of distinct endosomes.

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prefLabel

Formation of α-synuclein Lewy ...... ansport of distinct endosomes.

@ast

Formation of α-synuclein Lewy ...... ansport of distinct endosomes.

@en

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MBC.E14-02-0741

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Molecular Biology of the Cell

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Formation of α-synuclein Lewy ...... ansport of distinct endosomes.

@en

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Christine E Schultheiss

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Dawn M Riddle

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Laura A Volpicelli-Daley

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Virginia M-Y Lee

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P2860

The mammalian phosphatidylinositol 3-phosphate 5-kinase (PIKfyve) regulates endosome-to-TGN retrograde transport.

Gaucher disease glucocerebrosidase and α-synuclein form a bidirectional pathogenic loop in synucleinopathies

RAB7L1 interacts with LRRK2 to modify intraneuronal protein sorting and Parkinson's disease risk

Localization of phosphatidylinositol 3-phosphate in yeast and mammalian cells

Double-knockout mice for alpha- and beta-synucleins: effect on synaptic functions

Staging of brain pathology related to sporadic Parkinson's disease

Distinct α-synuclein strains differentially promote tau inclusions in neurons

Snapin-regulated late endosomal transport is critical for efficient autophagy-lysosomal function in neurons

Autophagosome formation: core machinery and adaptations

Dissection of the autophagosome maturation process by a novel reporter protein, tandem fluorescent-tagged LC3

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4010-4023

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scholarly article

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10.1091/MBC.E14-02-0741

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25

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25

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Karen L. Gamble

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2014-10-08T00:00:00Z

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25298402

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4263445

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