Paullones are potent inhibitors of glycogen synthase kinase-3beta and cyclin-dependent kinase 5/p25.
about
GSK-3 Inhibitors: Preclinical and Clinical Focus on CNSGlycogen synthase kinase 3: more than a namesakeEvidence for irreversible inhibition of glycogen synthase kinase-3β by tideglusibGSK-3: tricks of the trade for a multi-tasking kinaseSilencing of CDK5 reduces neurofibrillary tangles in transgenic alzheimer's miceLithium facilitates apoptotic signaling induced by activation of the Fas death domain-containing receptorGSK3beta in ethanol neurotoxicityAdaptive cellular stress pathways as therapeutic targets of dietary phytochemicals: focus on the nervous systemThe specificities of protein kinase inhibitors: an updateGlycogen synthase kinase-3 in the etiology and treatment of mood disorders.Macroautophagy deficiency mediates age-dependent neurodegeneration through a phospho-tau pathway.p42/p44 MAPKs are intracellular targets of the CDK inhibitor purvalanol.Inhibitors of Leishmania mexicana CRK3 cyclin-dependent kinase: chemical library screen and antileishmanial activity.Efficacy of small-molecule glycogen synthase kinase-3 inhibitors in the postnatal rat model of tau hyperphosphorylationHuman cytomegaloviruses expressing yellow fluorescent fusion proteins--characterization and use in antiviral screening.Designing of dual inhibitors for GSK-3β and CDK5: Virtual screening and in vitro biological activities studySmall-Molecule Suppressors of Cytokine-Induced beta-Cell Apoptosis.Inhibition of human immunodeficiency virus type-1 by cdk inhibitorsGlycogen synthase kinase-3 regulates inflammatory tolerance in astrocytes.Use of kinase inhibitors to correct ΔF508-CFTR function.Activation of canonical Wnt/β-catenin signaling stimulates proliferation in neuromasts in the zebrafish posterior lateral line.Ruthenium- and Osmium-Arene Complexes of 2-Substituted Indolo[3,2-c]quinolines: Synthesis, Structure, Spectroscopic Properties, and Antiproliferative Activity.Axial patterning in hydra.Structure-activity relationship study of 2,4-diaminothiazoles as Cdk5/p25 kinase inhibitors.Glycogen synthase kinase 3 (GSK-3) inhibitors as new promising drugs for diabetes, neurodegeneration, cancer, and inflammation.Overexpression of glycogen synthase kinase 3beta sensitizes neuronal cells to ethanol toxicityActivation of beta-catenin signalling by GSK-3 inhibition increases p-glycoprotein expression in brain endothelial cells.LiCl induces TNF-α and FasL production, thereby stimulating apoptosis in cancer cellsCyclin-dependent kinase 5 is a regulator of podocyte differentiation, proliferation, and morphologyAdvances in tau-based drug discovery.Glycogen synthase kinase-3: a promising therapeutic target for fragile x syndromeEmerging experimental therapeutics for bipolar disorder: insights from the molecular and cellular actions of current mood stabilizers.E-pharmacophore-based virtual screening to identify GSK-3β inhibitors.Small-Molecule Inhibitors of GSK-3: Structural Insights and Their Application to Alzheimer's Disease ModelsStructure-guided design of a highly selective glycogen synthase kinase-3β inhibitor: a superior neuroprotective pyrazolone showing antimania effectsNeural precursor cells are protected from apoptosis induced by trophic factor withdrawal or genotoxic stress by inhibitors of glycogen synthase kinase 3.Current strategies for the treatment of Alzheimer's disease and other tauopathies.Novel MicroRNA Reporter Uncovers Repression of Let-7 by GSK-3βTau as a therapeutic target in neurodegenerative disease.Glycogen synthase kinase-3 regulates microglial migration, inflammation, and inflammation-induced neurotoxicity.
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P2860
Paullones are potent inhibitors of glycogen synthase kinase-3beta and cyclin-dependent kinase 5/p25.
description
2000 nî lūn-bûn
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2000 թուականի Հոկտեմբերին հրատարակուած գիտական յօդուած
@hyw
2000 թվականի հոտեմբերին հրատարակված գիտական հոդված
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2000年の論文
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2000年論文
@yue
2000年論文
@zh-hant
2000年論文
@zh-hk
2000年論文
@zh-mo
2000年論文
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2000年论文
@wuu
name
Paullones are potent inhibitor ...... cyclin-dependent kinase 5/p25.
@ast
Paullones are potent inhibitor ...... cyclin-dependent kinase 5/p25.
@en
type
label
Paullones are potent inhibitor ...... cyclin-dependent kinase 5/p25.
@ast
Paullones are potent inhibitor ...... cyclin-dependent kinase 5/p25.
@en
prefLabel
Paullones are potent inhibitor ...... cyclin-dependent kinase 5/p25.
@ast
Paullones are potent inhibitor ...... cyclin-dependent kinase 5/p25.
@en
P2093
P2860
P1433
P1476
Paullones are potent inhibitor ...... cyclin-dependent kinase 5/p25.
@en
P2093
A M Senderowicz
D W Zaharevitz
E A Sausville
G L Snyder
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P304
P356
10.1046/J.1432-1327.2000.01673.X
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P577
2000-10-01T00:00:00Z