Lipotoxicity disrupts incretin-regulated human β cell connectivity - Wikidata - wikimedia - TriplyDB

Lipotoxicity disrupts incretin-regulated human β cell connectivity

Lipotoxicity disrupts incretin-regulated human β cell connectivity

http://www.wikidata.org/entity/Q30634760

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ADCY5 couples glucose to insulin secretion in human islets Membrane Potential and Calcium Dynamics in Beta Cells from Mouse Pancreas Tissue Slices: Theory, Experimentation, and Analysis Lipotoxicity in the pancreatic beta cell: not just survival and function, but proliferation as well?Role of microRNAs in islet beta-cell compensation and failure during diabetes Non-alcoholic fatty liver disease and type 2 diabetes mellitus: the liver disease of our age?Testing pancreatic islet function at the single cell level by calcium influx with associated marker expression The Beta Cell in Its Cluster: Stochastic Graphs of Beta Cell Connectivity in the Islets of Langerhans Phase transitions in the multi-cellular regulatory behavior of pancreatic islet excitability The transcription factor Pax6 is required for pancreatic β cell identity, glucose-regulated ATP synthesis, and Ca2+ dynamics in adult mice Incretin-modulated beta cell energetics in intact islets of Langerhans.Inadequate Triglyceride Management Worsens the Durability of Dipeptidyl Peptidase-4 Inhibitor in Subjects with Type 2 Diabetes Mellitus JNK3 is required for the cytoprotective effect of exendin 4 Optical control of insulin release using a photoswitchable sulfonylurea Progressive glucose stimulation of islet beta cells reveals a transition from segregated to integrated modular functional connectivity patterns.Genetic targeting of a small fluorescent zinc indicator to cell surface for monitoring zinc secretion.Incretin action on bone: An added benefit?Defects in mitophagy promote redox-driven metabolic syndrome in the absence of TP53INP1 Proglucagon Promoter Cre-Mediated AMPK Deletion in Mice Increases Circulating GLP-1 Levels and Oral Glucose Tolerance.Rfx6 maintains the functional identity of adult pancreatic β cells.Loss of Liver Kinase B1 (LKB1) in Beta Cells Enhances Glucose-stimulated Insulin Secretion Despite Profound Mitochondrial Defects.Limited impact on glucose homeostasis of leptin receptor deletion from insulin- or proglucagon-expressing cells Decreases in Gap Junction Coupling Recovers Ca2+ and Insulin Secretion in Neonatal Diabetes Mellitus, Dependent on Beta Cell Heterogeneity and Noise Kin of IRRE-like Protein 2 Is a Phosphorylated Glycoprotein That Regulates Basal Insulin Secretion.Low Level Pro-inflammatory Cytokines Decrease Connexin36 Gap Junction Coupling in Mouse and Human Islets through Nitric Oxide-mediated Protein Kinase Cδ.The two pore channel TPC2 is dispensable in pancreatic β-cells for normal Ca²⁺ dynamics and insulin secretion.CoA protects against the deleterious effects of caloric overload in Drosophila Sorcin Links Pancreatic β-Cell Lipotoxicity to ER Ca2+ Stores.Molecular Genetic Regulation of Slc30a8/ZnT8 Reveals a Positive Association With Glucose Tolerance.Changes in the expression of the type 2 diabetes-associated gene VPS13C in the β-cell are associated with glucose intolerance in humans and mice.Beta Cell Hubs Dictate Pancreatic Islet Responses to Glucose.MiRNAs in β-Cell Development, Identity, and Disease.New insights into the role of connexins in pancreatic islet function and diabetes.Minireview: intraislet regulation of insulin secretion in humans.Cellular communication and heterogeneity in pancreatic islet insulin secretion dynamics.Dorothy Hodgkin Lecture 2014. Understanding genes identified by genome-wide association studies for type 2 diabetes.Beta cell connectivity in pancreatic islets: a type 2 diabetes target?The past 10 years-new hormones, new functions, new endocrine organs.Elevated circulating stearic acid leads to a major lipotoxic effect on mouse pancreatic beta cells in hyperlipidaemia via a miR-34a-5p-mediated PERK/p53-dependent pathway.Optical Control of Insulin Secretion Using an Incretin Switch.Fluorescence recovery after photobleaching reveals regulation and distribution of connexin36 gap junction coupling within mouse islets of Langerhans.

P2860

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P2860

Lipotoxicity disrupts incretin-regulated human β cell connectivity

http://www.wikidata.org/entity/Q30634760

description

2013 nî lūn-bûn

@nan

2013 թուականի Սեպտեմբերին հրատարակուած գիտական յօդուած

@hyw

2013 թվականի սեպտեմբերին հրատարակված գիտական հոդված

@hy

2013年の論文

@ja

2013年学术文章

@wuu

2013年学术文章

@zh-cn

2013年学术文章

@zh-hans

2013年学术文章

@zh-my

2013年学术文章

@zh-sg

2013年學術文章

@yue

name

Lipotoxicity disrupts incretin-regulated human β cell connectivity

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Lipotoxicity disrupts incretin-regulated human β cell connectivity

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type

label

Lipotoxicity disrupts incretin-regulated human β cell connectivity

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Lipotoxicity disrupts incretin-regulated human β cell connectivity

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prefLabel

Lipotoxicity disrupts incretin-regulated human β cell connectivity

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Lipotoxicity disrupts incretin-regulated human β cell connectivity

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Journal of Clinical Investigation

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Lipotoxicity disrupts incretin-regulated human β cell connectivity

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Daliang Li

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Domenico Bosco

http://www.w3.org/2001/XMLSchema#string

Gao Sun

http://www.w3.org/2001/XMLSchema#string

Laurent Vinet

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Paolo Meda

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Paul Johnson

http://www.w3.org/2001/XMLSchema#string

Stephen J Hughes

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Wen-Hong Li

http://www.w3.org/2001/XMLSchema#string

P2860

The mitochondrial Ca2+ uniporter MCU is essential for glucose-induced ATP increases in pancreatic β-cells

The unique cytoarchitecture of human pancreatic islets has implications for islet cell function

Alpha cells secrete acetylcholine as a non-neuronal paracrine signal priming beta cell function in humans

Critical role of gap junction coupled KATP channel activity for regulated insulin secretion

Glucose-stimulated calcium dynamics in islets of Langerhans in acute mouse pancreas tissue slices

Functional connectivity in islets of Langerhans from mouse pancreas tissue slices

The multiple actions of GLP-1 on the process of glucose-stimulated insulin secretion.

Double incretin receptor knockout (DIRKO) mice reveal an essential role for the enteroinsular axis in transducing the glucoregulatory actions of DPP-IV inhibitors

The Physiology of Glucagon-like Peptide 1

Glucagon-like peptide-1 receptor signaling modulates beta cell apoptosis

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4182-4194

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scholarly article

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10.1172/JCI68459

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10

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123

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Ryan K Mitchell

Lorenzo Piemonti

Piero Marchetti

Elisa A. Bellomo

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2013-09-09T00:00:00Z

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24018562

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4382273

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