Evaluation of human intestinal absorption data and subsequent derivation of a quantitative structure-activity relationship (QSAR) with the Abraham descriptors.
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A long-duration dihydroorotate dehydrogenase inhibitor (DSM265) for prevention and treatment of malariaDeveloping a Physiologically-Based Pharmacokinetic Model Knowledgebase in Support of Provisional Model ConstructionADMET evaluation in drug discovery. 12. Development of binary classification models for prediction of hERG potassium channel blockagePrediction of in vivo drug interactions with eplerenone in man from in vitro metabolic inhibition data.Exploring different strategies for imbalanced ADME data problem: case study on Caco-2 permeability modeling.Can the Internet help to meet the challenges in ADME and e-ADME?The design of orally bioavailable 2, 5-diketopiperazine oxytocin antagonists: from concept to clinical candidate for premature labor.BDDCS applied to over 900 drugs.Quantitation of small intestinal permeability during normal human drug absorption.Predictive approaches to increase absorption of compounds during lead optimisation.Use of in-silico assays to characterize the ADMET profile and identify potential therapeutic targets of fusarochromanone, a novel anti-cancer agentA concise review of applications of micellar liquid chromatography to study biologically active compounds.Skin-mimetic chromatography for prediction of human percutaneous absorption of biologically active compounds occurring in medicinal plant extracts.Characterisation of data resources for in silico modelling: benchmark datasets for ADME properties.Computational models to predict aqueous drug solubility, permeability and intestinal absorption.Structure-activity models of oral clearance, cytotoxicity, and LD50: a screen for promising anticancer compounds.Structure-based design and synthesis of benzothiazole phosphonate analogues with inhibitors of human ABAD-Aβ for treatment of Alzheimer's disease.Prediction of human pharmacokinetics--gastrointestinal absorption.Modelling and simulation in drug absorption processes.Prediction of human pharmacokinetics - renal metabolic and excretion clearance.Prediction of human intestinal absorption by GA feature selection and support vector machine regression.Modeling kinetics of subcellular disposition of chemicals.Encapsulation of hydrocortisone and mesalazine in zein microparticles.Intestinal transportations of main chemical compositions of polygoni multiflori radix in caco-2 cell model.Informatics, machine learning and computational medicinal chemistry.Using artificial neural networks to predict cell-penetrating compounds.Synthesis of an anthraquinone derivative (DHAQC) and its effect on induction of G2/M arrest and apoptosis in breast cancer MCF-7 cell line.Computational-Regulatory Developments in the Prediction of Oral Drug Absorption.A QSAR, pharmacokinetic and toxicological study of new artemisinin compounds with anticancer activity.Total synthesis, cytotoxic effects of damnacanthal, nordamnacanthal and related anthraquinone analogues.Lipophilicity and biomimetic properties to support drug discovery.Multiple Kernel Learning for Drug Discovery.Identification of potential drug targets by subtractive genome analysis of Escherichia coli O157:H7: an in silico approach.Preparation and Evaluation of Potent Pentafluorosulfanyl-Substituted Anti-Tuberculosis Compounds.In vitro prediction of human intestinal absorption and blood-brain barrier partitioning: development of a lipid analog for micellar liquid chromatography.Optimizing Prednisolone Loading into Distiller's Dried Grain Kafirin Microparticles, and In vitro Release for Oral DeliveryComputational Analysis of Gynura bicolor Bioactive Compounds as Dipeptidyl Peptidase-IV Inhibitor.Molecular docking of selected phytocompounds with H1N1 Proteins.Integrated pharmacokinetic-driven approach to screen candidate anticancer drugs for brain tumor chemotherapy.Solvent effects on the structure-property relationship of anticonvulsant hydantoin derivatives: A solvatochromic analysis.
P2860
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P2860
Evaluation of human intestinal absorption data and subsequent derivation of a quantitative structure-activity relationship (QSAR) with the Abraham descriptors.
description
2001 nî lūn-bûn
@nan
2001 թուականի Յունիսին հրատարակուած գիտական յօդուած
@hyw
2001 թվականի հունիսին հրատարակված գիտական հոդված
@hy
2001年の論文
@ja
2001年論文
@yue
2001年論文
@zh-hant
2001年論文
@zh-hk
2001年論文
@zh-mo
2001年論文
@zh-tw
2001年论文
@wuu
name
Evaluation of human intestinal ...... with the Abraham descriptors.
@ast
Evaluation of human intestinal ...... with the Abraham descriptors.
@en
type
label
Evaluation of human intestinal ...... with the Abraham descriptors.
@ast
Evaluation of human intestinal ...... with the Abraham descriptors.
@en
prefLabel
Evaluation of human intestinal ...... with the Abraham descriptors.
@ast
Evaluation of human intestinal ...... with the Abraham descriptors.
@en
P2093
P356
P1476
Evaluation of human intestinal ...... ) with the Abraham descriptors
@en
P2093
B Sherborne
C N Luscombe
M H Abraham
P J Eddershaw
P304
P356
10.1002/JPS.1031
P407
P577
2001-06-01T00:00:00Z