Peptide deformylase in Staphylococcus aureus: resistance to inhibition is mediated by mutations in the formyltransferase gene
about
Human mitochondrial peptide deformylase, a new anticancer target of actinonin-based antibioticsAntibiotic Activity and Characterization of BB-3497, a Novel Peptide Deformylase InhibitorStructural variation and inhibitor binding in polypeptide deformylase from four different bacterial speciesThe Role of a Novel Auxiliary Pocket in Bacterial Phenylalanyl-tRNA Synthetase DruggabilityEukaryotic peptide deformylases. Nuclear-encoded and chloroplast-targeted enzymes in ArabidopsisNew antibiotic molecules: bypassing the membrane barrier of gram negative bacteria increases the activity of peptide deformylase inhibitorsFmt bypass in Pseudomonas aeruginosa causes induction of MexXY efflux pump expressionThe Pseudomonas aeruginosa initiation factor IF-2 is responsible for formylation-independent protein initiation in P. aeruginosaH2-M3-restricted CD8+ T cells are not required for MHC class Ib-restricted immunity against Listeria monocytogenesReduced susceptibility of Haemophilus influenzae to the peptide deformylase inhibitor LBM415 can result from target protein overexpression due to amplified chromosomal def gene copy number.Comparative antimicrobial characterization of LBM415 (NVP PDF-713), a new peptide deformylase inhibitor of clinical importance.Resistance of Streptococcus pneumoniae to deformylase inhibitors is due to mutations in defB.N-alkyl urea hydroxamic acids as a new class of peptide deformylase inhibitors with antibacterial activityPeptide deformylase: a target for novel antibiotics?Role of N-terminal protein formylation in central metabolic processes in Staphylococcus aureus.Reducing the fitness cost of antibiotic resistance by amplification of initiator tRNA genes.Peptide deformylase inhibitors as potent antimycobacterial agents.Determination of the core of a minimal bacterial gene setNew advances in antibiotic development and discovery.Anti-MRSA agents: under investigation, in the exploratory phase and clinically available.Therapeutic potential of peptide deformylase inhibitors.Zinc is the metal cofactor of Borrelia burgdorferi peptide deformylase.Novel approaches to developing new antibiotics for bacterial infections.Drug forecast - the peptide deformylase inhibitors as antibacterial agents.Investigational treatments for postoperative surgical site infections.Expression, crystallization and preliminary X-ray crystallographic analysis of peptide deformylase from Xanthomonas oryzae pv. oryzaeMutations in three distinct loci cause resistance to peptide deformylase inhibitors in Bacillus subtilis.The Inhibition and Resistance Mechanisms of Actinonin, Isolated from Marine Streptomyces sp. NHF165, against Vibrio anguillarum.A unique peptide deformylase platform to rationally design and challenge novel active compounds.Potent sub-MIC effect of GSK1322322 and other peptide deformylase inhibitors on in vitro growth of Staphylococcus aureus.Sequencing of bacterial genomes: principles and insights into pathogenesis and development of antibiotics.Marine bacteria: potential sources for compounds to overcome antibiotic resistance.Three consecutive arginines are important for the mycobacterial peptide deformylase enzyme activityEnemy attraction: bacterial agonists for leukocyte chemotaxis receptors.Crystallization and preliminary X-ray crystallographic analysis of peptide deformylase (PDF) from Bacillus cereus in ligand-free and actinonin-bound forms.Evaluation of antibacterial and antibiofilm mechanisms by usnic acid against methicillin-resistant Staphylococcus aureus.Lack of formylated methionyl-tRNA has pleiotropic effects on Bacillus subtilis.Identification of regions involved in enzymatic stability of peptide deformylase of Mycobacterium tuberculosis.Comparative analysis of the antibacterial activity of a novel peptide deformylase inhibitor, GSK1322322.Small molecule inhibition of apicomplexan FtsH1 disrupts plastid biogenesis in human pathogens.
P2860
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P2860
Peptide deformylase in Staphylococcus aureus: resistance to inhibition is mediated by mutations in the formyltransferase gene
description
2000 nî lūn-bûn
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2000 թուականի Յուլիսին հրատարակուած գիտական յօդուած
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2000 թվականի հուլիսին հրատարակված գիտական հոդված
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2000年の論文
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2000年論文
@yue
2000年論文
@zh-hant
2000年論文
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2000年論文
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2000年論文
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2000年论文
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name
Peptide deformylase in Staphyl ...... in the formyltransferase gene
@ast
Peptide deformylase in Staphyl ...... in the formyltransferase gene
@en
type
label
Peptide deformylase in Staphyl ...... in the formyltransferase gene
@ast
Peptide deformylase in Staphyl ...... in the formyltransferase gene
@en
prefLabel
Peptide deformylase in Staphyl ...... in the formyltransferase gene
@ast
Peptide deformylase in Staphyl ...... in the formyltransferase gene
@en
P2093
P2860
P1476
Peptide deformylase in Staphyl ...... in the formyltransferase gene
@en
P2093
Hackbarth CJ
Margolis PS
P2860
P304
P356
10.1128/AAC.44.7.1825-1831.2000
P407
P577
2000-07-01T00:00:00Z