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Mutagenicity of the peroxisome proliferators clofibrate, Wyeth 14,643 and di-2-ethylhexyl phthalate in the lacZ plasmid-based transgenic mouse mutation assayThe role of transgenic mouse models in carcinogen identificationPET/CT imaging of c-Myc transgenic mice identifies the genotoxic N-nitroso-diethylamine as carcinogen in a short-term cancer bioassayDiscrimination of carcinogens by hepatic transcript profiling in rats following 28-day administrationProliferative and non-proliferative lesions of the rat and mouse integument.Spontaneous tumor incidence in rasH2 mice: review of internal data and published literature.Historical control data of spontaneous tumors in transgenic CByB6F1-Tg(HRAS)2Jic (Tg.rasH2) mice.Nonclinical safety profile of telbivudine, a novel potent antiviral agent for treatment of hepatitis BSuccessful drug development despite adverse preclinical findings part 2: examples.Power, expertise and the limits of representative democracy: genetics as scientific progress or political legitimation in carcinogenic risk assessment of pharmaceuticals?A tiered approach to systemic toxicity testing for agricultural chemical safety assessment.Mouse skin models for carcinogenic hazard identification: utilities and challenges.Science, politics, and health in the brave new world of pharmaceutical carcinogenic risk assessment: technical progress or cycle of regulatory capture?An industry perspective on the utility of short-term carcinogenicity testing in transgenic mice in pharmaceutical development.Alternative mouse models for carcinogenicity assessment: industry use and issues with pathology interpretation.Carcinogenicity assessments of biotechnology-derived pharmaceuticals: a review of approved molecules and best practice recommendations.Critical review of preclinical approaches to evaluate the potential of immunosuppressive drugs to influence human neoplasia.Establishing a laboratory animal model from a transgenic animal: RasH2 mice as a model for carcinogenicity studies in regulatory science.A critical appraisal of the process of regulatory implementation of novel in vivo and in vitro methods for chemical hazard and risk assessment.Twenty-six-week oral carcinogenicity study of 3-monochloropropane-1,2-diol in CB6F1-rasH2 transgenic mice.Regulatory Forum commentary: alternative mouse models for future cancer risk assessment.Progression of Serosal Vascular Proliferative Lesions to Hemangiosarcomas in the Uterus of the 26-Week Tg.rasH2 Mice Carcinogenicity Studies.Hematopoietic proliferative lesions in the spleen of rasH2 transgenic mice treated with MNU.26-Week carcinogenicity study of di-isodecyl phthalate by dietary administration to CB6F1-rasH2 transgenic mice.Interlaboratory comparison of short-term carcinogenicity studies using CB6F1-rasH2 transgenic mice.Effect of oral gavage dosing regimens in female Tg rasH2 transgenic mice.Hepatocarcinogenic susceptibility of fenofibrate and its possible mechanism of carcinogenicity in a two-stage hepatocarcinogenesis model of rasH2 mice.N-Methyl-N-Nitrosourea (MNU): A positive control chemical for p53+/- mouse carcinogenicity studies.A 26-week carcinogenicity study of 2-amino-3-methylimidazo[4,5-f]quinoline in rasH2 mice.Relationship of body weight parameters with the incidence of common spontaneous tumors in Tg.rasH2 mice.Lung Tumor Induction by 26-week Dermal Application of 1,2-Dichloroethane in CB6F1-Tg rasH2 Mice.Reduction in the number of animals and the evaluation period for the positive control group in Tg.rasH2 short-term carcinogenicity studies.Differential display in rat livers treated for 13 weeks with phenobarbital implicates a role for metabolic and oxidative stress in nongenotoxic carcinogenicity.An integrative test strategy for cancer hazard identification.Tumor promotion by 12-O-tetradecanoylphorbol-13-acetate in an ultra-short-term skin carcinogenesis bioassay using rasH2 mice.High susceptibility of human c-Ha-ras proto-oncogene transgenic rats to carcinogenesis: a cancer-prone animal model.
P2860
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P2860
description
2001 nî lūn-bûn
@nan
2001 թուականի Յունուարին հրատարակուած գիտական յօդուած
@hyw
2001 թվականի հունվարին հրատարակված գիտական հոդված
@hy
2001年の論文
@ja
2001年論文
@yue
2001年論文
@zh-hant
2001年論文
@zh-hk
2001年論文
@zh-mo
2001年論文
@zh-tw
2001年论文
@wuu
name
CB6F1-rasH2 mouse: overview of available data.
@ast
CB6F1-rasH2 mouse: overview of available data.
@en
type
label
CB6F1-rasH2 mouse: overview of available data.
@ast
CB6F1-rasH2 mouse: overview of available data.
@en
prefLabel
CB6F1-rasH2 mouse: overview of available data.
@ast
CB6F1-rasH2 mouse: overview of available data.
@en
P2093
P1476
CB6F1-rasH2 mouse: overview of available data.
@en
P2093
B McCullough
P304
P356
10.1080/019262301753178500
P407
P478
P577
2001-01-01T00:00:00Z