Synthesis, aggregation, and neurotoxicity of the Alzheimer's Abeta1-42 amyloid peptide and its isoaspartyl isomers.

Synthesis, aggregation, and neurotoxicity of the Alzheimer's Abeta1-42 amyloid peptide and its isoaspartyl isomers.

Item
http://www.wikidata.org/entity/Q30681461
Efficient access to highly pure β-amyloid peptide by optimized solid-phase synthesis.Identification of amino acid epimerization and isomerization in crystallin proteins by tandem LC-MSMonoclonal antibody with conformational specificity for a toxic conformer of amyloid β42 and its application toward the Alzheimer's disease diagnosis.Truncated and modified amyloid-beta species.Improved chemical synthesis of hydrophobic Aβ peptides using addition of C-terminal lysines later removed by carboxypeptidase B.MER5101, a novel Aβ1-15:DT conjugate vaccine, generates a robust anti-Aβ antibody response and attenuates Aβ pathology and cognitive deficits in APPswe/PS1ΔE9 transgenic miceIdentification of aspartic and isoaspartic acid residues in amyloid beta peptides, including Abeta1-42, using electron-ion reactionsChange of dynamics of raft-model membrane induced by amyloid-β protein binding.Beta-amyloid enhances glial glutamate uptake activity and attenuates synaptic efficacy.Transgenic expression of the protein-L-isoaspartyl methyltransferase (PIMT) gene in the brain rescues mice from the fatal epilepsy of PIMT deficiency.Isoaspartate formation at position 23 of amyloid beta peptide enhanced fibril formation and deposited onto senile plaques and vascular amyloids in Alzheimer's disease.Analysis of the secondary structure of beta-amyloid (Abeta42) fibrils by systematic proline replacement.APP/Aβ structural diversity and Alzheimer's disease pathogenesis.Distinguishing d- and l-aspartic and isoaspartic acids in amyloid β peptides with ultrahigh resolution ion mobility spectrometry.Peripherally applied synthetic peptide isoAsp7-Aβ(1-42) triggers cerebral β-amyloidosis.Intravenously Injected Amyloid-β Peptide With Isomerized Asp7 and Phosphorylated Ser8 Residues Inhibits Cerebral β-Amyloidosis in AβPP/PS1 Transgenic Mice Model of Alzheimer's DiseaseImplications of Metal Binding and Asparagine Deamidation for Amyloid Formation
P2860

Synthesis, aggregation, and neurotoxicity of the Alzheimer's Abeta1-42 amyloid peptide and its isoaspartyl isomers.

Item
http://www.wikidata.org/entity/Q30681461
description
1999 nî lūn-bûn
@nan
1999 թուականի Ապրիլին հրատարակուած գիտական յօդուած
@hyw
1999 թվականի ապրիլին հրատարակված գիտական հոդված
@hy
1999年の論文
@ja
1999年論文
@yue
1999年論文
@zh-hant
1999年論文
@zh-hk
1999年論文
@zh-mo
1999年論文
@zh-tw
1999年论文
@wuu
name
Synthesis, aggregation, and ne ...... e and its isoaspartyl isomers.
@ast
Synthesis, aggregation, and ne ...... e and its isoaspartyl isomers.
@en
type
label
Synthesis, aggregation, and ne ...... e and its isoaspartyl isomers.
@ast
Synthesis, aggregation, and ne ...... e and its isoaspartyl isomers.
@en
prefLabel
Synthesis, aggregation, and ne ...... e and its isoaspartyl isomers.
@ast
Synthesis, aggregation, and ne ...... e and its isoaspartyl isomers.
@en
P1433
P1476
P2093
P304
P31
P356
P407
P433
P478
P577
P698
P921
P356
P1433
P1476
Synthesis, aggregation, and ne ...... e and its isoaspartyl isomers.
@en
P2093
P304
P31
P356
10.1016/S0960-894X(99)00121-3
P407
P433
P478
P577
P698
P921