LY395756, an mGluR2 agonist and mGluR3 antagonist, enhances NMDA receptor expression and function in the normal adult rat prefrontal cortex, but fails to improve working memory and reverse MK801-induced working memory impairment.
about
Targeting metabotropic glutamate receptors for novel treatments of schizophrenia.Glutamatergic regulation of cognition and functional brain connectivity: insights from pharmacological, genetic and translational schizophrenia research.Juvenile treatment with a novel mGluR2 agonist/mGluR3 antagonist compound, LY395756, reverses learning deficits and cognitive flexibility impairments in adults in a neurodevelopmental model of schizophrenia.Juvenile treatment with mGluR2/3 agonist prevents schizophrenia-like phenotypes in adult by acting through GSK3β.
P2860
LY395756, an mGluR2 agonist and mGluR3 antagonist, enhances NMDA receptor expression and function in the normal adult rat prefrontal cortex, but fails to improve working memory and reverse MK801-induced working memory impairment.
description
2015 nî lūn-bûn
@nan
2015 թուականի Սեպտեմբերին հրատարակուած գիտական յօդուած
@hyw
2015 թվականի սեպտեմբերին հրատարակված գիտական հոդված
@hy
2015年の論文
@ja
2015年論文
@yue
2015年論文
@zh-hant
2015年論文
@zh-hk
2015年論文
@zh-mo
2015年論文
@zh-tw
2015年论文
@wuu
name
LY395756, an mGluR2 agonist an ...... ced working memory impairment.
@ast
LY395756, an mGluR2 agonist an ...... ced working memory impairment.
@en
type
label
LY395756, an mGluR2 agonist an ...... ced working memory impairment.
@ast
LY395756, an mGluR2 agonist an ...... ced working memory impairment.
@en
prefLabel
LY395756, an mGluR2 agonist an ...... ced working memory impairment.
@ast
LY395756, an mGluR2 agonist an ...... ced working memory impairment.
@en
P2093
P2860
P1476
LY395756, an mGluR2 agonist an ...... ced working memory impairment.
@en
P2093
Meng-Lin Li
Sha-Sha Yang
Wen-Jun Gao
Xi-Quan Hu
Yan-Chun Li
Yelena Gulchina
P2860
P304
P356
10.1016/J.EXPNEUROL.2015.08.019
P407
P577
2015-09-01T00:00:00Z