A combinatorial scaffold approach toward kinase-directed heterocycle libraries.
about
High-throughput chemical screen identifies a novel potent modulator of cellular circadian rhythms and reveals CKIα as a clock regulatory kinaseDiscovery of 1-(4-(4-propionylpiperazin-1-yl)-3-(trifluoromethyl)phenyl)-9-(quinolin-3-yl)benzo[h][1,6]naphthyridin-2(1H)-one as a highly potent, selective mammalian target of rapamycin (mTOR) inhibitor for the treatment of cancerAryl hydrocarbon receptor antagonists promote the expansion of human hematopoietic stem cellsSelf-renewal of embryonic stem cells by a small moleculeFirst-in-Class Inhibitors of Sulfur Metabolism with Bactericidal Activity against Non-Replicating M. tuberculosisSynthetic small molecules that control stem cell fateDiversity-oriented synthesis: exploring the intersections between chemistry and biology.A unified synthetic approach to polyketides having both skeletal and stereochemical diversity.Small-molecule synergist of the Wnt/beta-catenin signaling pathway.A small molecule inhibitor of alpha4 integrin-dependent cell migration.An image-based screen identifies a small molecule regulator of megakaryopoiesis.Transitioning pharmacoperones to therapeutic use: in vivo proof-of-principle and design of high throughput screens.Diversity through a branched reaction pathway: generation of multicyclic scaffolds and identification of antimigratory agents.High-throughput kinase profiling: a more efficient approach toward the discovery of new kinase inhibitors.Chemical biology in stem cell research.Identification of small molecule activators of cryptochromeMicroscale technologies for tissue engineering and biologyEmulating the logic of monoterpenoid alkaloid biogenesis to access a skeletally diverse chemical library.HTS/HCS to screen molecules able to maintain embryonic stem cell self-renewal or to induce differentiation: overview of protocols.Fluorous synthesis of disubstituted pyrimidines.Inhibition of histone deacetylase activity induces developmental plasticity in oligodendrocyte precursor cells.Identification of Potential Pharmacoperones Capable of Rescuing the Functionality of Misfolded Vasopressin 2 Receptor Involved in Nephrogenic Diabetes InsipidusDifferentiation pathways in human embryonic stem cell-derived cardiomyocytes."Reversine" and its 2-substituted adenine derivatives as potent and selective A3 adenosine receptor antagonistsSynthesis at the interface of chemistry and biology.Back to the future: lessons learned in modern target-based and whole-cell lead optimization of antimalarials.Development of highly selective casein kinase 1δ/1ε (CK1δ/ε) inhibitors with potent antiproliferative propertiesDevelopment of ATP-competitive mTOR inhibitors.Expanding the diversity of allosteric bcr-abl inhibitors.Effects of Bioactive Compounds on Odontogenic Differentiation and Mineralization.Synthesis and Structure-Activity Relationship Study of 1-Phenyl-1-(quinazolin-4-yl)ethanols as Anticancer Agents.Facilitation of addition-elimination reactions in pyrimidines and purines using trifluoroacetic acid in trifluoroethanol.Hedgehog signaling and osteoblast gene expression are regulated by purmorphamine in human mesenchymal stem cells.Renewing embryonic stem cells
P2860
Q21563543-559B6A35-386E-4380-8AB9-B42937502929Q24617184-479E2229-92F4-4F52-BE63-1E18F13D8994Q24630871-DF7E6073-3CF3-4818-BB5E-DC43B9F7AB12Q24676820-53D4620D-E9F9-4F68-9745-8C088493015AQ28354028-9EF5DDDB-E749-419D-8796-F96267247ED7Q30945332-5ED3CFD6-9441-4CBA-8447-E791246F6B99Q33231454-67E6B14F-9643-4317-8834-B38A71D7EC30Q33282271-883E06E9-781A-48B4-9F76-14657D12FF0EQ33282822-88EA73BA-20F1-47C5-B452-618025D01E34Q33323130-F45DAF71-B8B0-4A2F-9189-2E338F775968Q33402801-B370189A-944C-484A-BA6E-FCE090D206FFQ33717398-24BCD898-5062-4B11-A3D5-A22EF7773586Q33786011-95AEF7C7-9712-4228-BF36-7C985BEF1C83Q33975831-9ED7883F-8D87-4B62-894F-2EBBF6BF1E00Q34174339-12B48786-D440-4438-9F88-75C7B7B2B872Q34288305-7E9FA3A4-C199-4F66-B0C8-C6368DE65907Q34479429-D5122551-DD14-4111-BEFD-E21E8F0EFBB1Q34927981-60C36B5C-C395-4879-A6D5-5BC94440EFDFQ35203982-C647AF94-CE39-405D-BFB1-59A9BB26A779Q35762365-BABE247A-3241-443A-8867-31579D447942Q36002535-E13EE439-D142-4D9F-B794-15864158D080Q36046576-FD7EFB8C-78F9-4005-B8E9-3624F95B7467Q36225114-361E5264-88EA-4205-BAAA-CDDD1C8FAFC8Q36327179-4DFCCE23-E900-4DA7-8913-9601F6E279D8Q37581575-136A8E16-0226-4782-9D59-D977A133C429Q37975527-4FC20701-7015-4184-9B5D-FAB2EF285D0CQ38453772-BE4F5493-3635-4F70-BE7F-970B54EF9B53Q38473974-705064D1-0D25-4BFD-80B0-2B892BD04ACEQ39657684-3998A307-043F-4D18-A8F6-9A777ABF1BAEQ40403277-08F1D075-FA24-4BC0-B282-347C4967E326Q41992828-AA2AE2D7-068E-47FF-A114-57183F1D2EC9Q44677043-C0EC6176-A31C-46F5-850A-D920B497EFCCQ50610661-DD8E51C1-9C31-4BCE-939A-87D51B5DFFBFQ59029711-6C001C43-EE92-4AB8-940A-EED672688F6E
P2860
A combinatorial scaffold approach toward kinase-directed heterocycle libraries.
description
2002 nî lūn-bûn
@nan
2002 թուականի Փետրուարին հրատարակուած գիտական յօդուած
@hyw
2002 թվականի փետրվարին հրատարակված գիտական հոդված
@hy
2002年の論文
@ja
2002年論文
@yue
2002年論文
@zh-hant
2002年論文
@zh-hk
2002年論文
@zh-mo
2002年論文
@zh-tw
2002年论文
@wuu
name
A combinatorial scaffold approach toward kinase-directed heterocycle libraries.
@ast
A combinatorial scaffold approach toward kinase-directed heterocycle libraries.
@en
type
label
A combinatorial scaffold approach toward kinase-directed heterocycle libraries.
@ast
A combinatorial scaffold approach toward kinase-directed heterocycle libraries.
@en
prefLabel
A combinatorial scaffold approach toward kinase-directed heterocycle libraries.
@ast
A combinatorial scaffold approach toward kinase-directed heterocycle libraries.
@en
P2093
P356
P1476
A combinatorial scaffold approach toward kinase-directed heterocycle libraries.
@en
P2093
Nathanael S Gray
Peter G Schultz
Qiang Ding
Sheng Ding
P304
P356
10.1021/JA0170302
P407
P577
2002-02-01T00:00:00Z