Establishment of a binding assay for protein kinase C isozymes using synthetic C1 peptides and development of new medicinal leads with protein kinase C isozyme and C1 domain selectivity.

Establishment of a binding assay for protein kinase C isozymes using synthetic C1 peptides and development of new medicinal leads with protein kinase C isozyme and C1 domain selectivity.

Item
http://www.wikidata.org/entity/Q30844400
Identification of the activator-binding residues in the second cysteine-rich regulatory domain of protein kinase Cθ (PKCθ)Targeting of protein kinase C-epsilon during Fcgamma receptor-dependent phagocytosis requires the epsilonC1B domain and phospholipase C-gamma1.PKC-ε pseudosubstrate and catalytic activity are necessary for membrane delivery during IgG-mediated phagocytosis.Diacylglycerol-dependent binding recruits PKCtheta and RasGRP1 C1 domains to specific subcellular localizations in living T lymphocytes.Two new lyngbyatoxin derivatives from the Cyanobacterium, Moorea producens.Structural Basis for the Failure of the C1 Domain of Ras Guanine Nucleotide Releasing Protein 2 (RasGRP2) to Bind Phorbol Ester with High Affinity.Potential for pharmacological manipulation of human embryonic stem cells.The many hats of protein kinase Cδ: one enzyme with many functions.A comparison of the membrane binding properties of C1B domains of PKCgamma, PKCdelta, and PKCepsilon.A novel diacylglycerol-lactone shows marked selectivity in vitro among C1 domains of protein kinase C (PKC) isoforms alpha and delta as well as selectivity for RasGRP compared with PKCalpha.Alcohol binding in the C1 (C1A+C1B) domain of protein kinase C epsilon.Interfacial partitioning of a loop hinge residue contributes to diacylglycerol affinity of conserved region 1 domains.Modeling studies on the structural determinants for the DAG/phorbol ester binding to C1 domain.The C1 domain of Vav3, a novel potential therapeutic target.REDOR NMR Reveals Multiple Conformers for a Protein Kinase C Ligand in a Membrane Environment.Mutant protein kinase Cgamma found in spinocerebellar ataxia type 14 is susceptible to aggregation and causes cell death.Ethanol-Induced Changes in PKCε: From Cell to Behavior.
P2860

Establishment of a binding assay for protein kinase C isozymes using synthetic C1 peptides and development of new medicinal leads with protein kinase C isozyme and C1 domain selectivity.

Item
http://www.wikidata.org/entity/Q30844400
description
2002 nî lūn-bûn
@nan
2002 թուականի Փետրուարին հրատարակուած գիտական յօդուած
@hyw
2002 թվականի փետրվարին հրատարակված գիտական հոդված
@hy
2002年の論文
@ja
2002年論文
@yue
2002年論文
@zh-hant
2002年論文
@zh-hk
2002年論文
@zh-mo
2002年論文
@zh-tw
2002年论文
@wuu
name
Establishment of a binding ass ...... yme and C1 domain selectivity.
@ast
Establishment of a binding ass ...... yme and C1 domain selectivity.
@en
type
label
Establishment of a binding ass ...... yme and C1 domain selectivity.
@ast
Establishment of a binding ass ...... yme and C1 domain selectivity.
@en
prefLabel
Establishment of a binding ass ...... yme and C1 domain selectivity.
@ast
Establishment of a binding ass ...... yme and C1 domain selectivity.
@en
P1433
P1476
P2093
P304
P31
P356
P433
P478
P50
P577
P698
P356
P1433
P1476
Establishment of a binding ass ...... yme and C1 domain selectivity.
@en
P2093
P304
P31
P356
10.1016/S0163-7258(02)00196-1
P433
P478
P50
P577
P698