Dynamic removal of replication protein A by Dna2 facilitates primer cleavage during Okazaki fragment processing in Saccharomyces cerevisiae
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Acetylation of Dna2 endonuclease/helicase and flap endonuclease 1 by p300 promotes DNA stability by creating long flap intermediatesBiochemical analyses indicate that binding and cleavage specificities define the ordered processing of human Okazaki fragments by Dna2 and FEN1Okazaki fragment processing-independent role for human Dna2 enzyme during DNA replicationComponents of the secondary pathway stimulate the primary pathway of eukaryotic Okazaki fragment processingAn alternative pathway for Okazaki fragment processing: resolution of fold-back flaps by Pif1 helicaseDynamic binding of replication protein a is required for DNA repair.Structure and conformational change of a replication protein A heterotrimer bound to ssDNASystematic identification of cell cycle-dependent yeast nucleocytoplasmic shuttling proteins by prediction of composite motifsDna2 exhibits a unique strand end-dependent helicase function.Xenopus DNA2 is a helicase/nuclease that is found in complexes with replication proteins And-1/Ctf4 and Mcm10 and DSB response proteins Nbs1 and ATMSignificance of the dissociation of Dna2 by flap endonuclease 1 to Okazaki fragment processing in Saccharomyces cerevisiae.Pif1 helicase lengthens some Okazaki fragment flaps necessitating Dna2 nuclease/helicase action in the two-nuclease processing pathway.Dna2 is a structure-specific nuclease, with affinity for 5'-flap intermediates.Reconstitution of eukaryotic lagging strand DNA replication.Human nuclease/helicase DNA2 alleviates replication stress by promoting DNA end resection.Eukaryotic lagging strand DNA replication employs a multi-pathway mechanism that protects genome integrityCharacterization of the endonuclease and ATP-dependent flap endo/exonuclease of Dna2.The Saccharomyces cerevisiae Dna2 can function as a sole nuclease in the processing of Okazaki fragments in DNA replicationDna2 nuclease-helicase structure, mechanism and regulation by Rpa.Genetic Interactions Implicating Postreplicative Repair in Okazaki Fragment Processing.A Selective Small Molecule DNA2 Inhibitor for Sensitization of Human Cancer Cells to ChemotherapyOkazaki fragment metabolism.Sulfolobus chromatin proteins modulate strand displacement by DNA polymerase B1Dna2 on the road to Okazaki fragment processing and genome stability in eukaryotes.The role of the DNA sliding clamp in Okazaki fragment maturation in archaea and eukaryotes.A novel role of the Dna2 translocase function in DNA break resectionInviability of a DNA2 deletion mutant is due to the DNA damage checkpoint.Dynamic DNA binding, junction recognition and G4 melting activity underlie the telomeric and genome-wide roles of human CST.A Critical Role for Dna2 at Unwound Telomeres.Dna2 processes behind the fork long ssDNA flaps generated by Pif1 and replication-dependent strand displacement
P2860
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P2860
Dynamic removal of replication protein A by Dna2 facilitates primer cleavage during Okazaki fragment processing in Saccharomyces cerevisiae
description
2008 nî lūn-bûn
@nan
2008 թուականի Սեպտեմբերին հրատարակուած գիտական յօդուած
@hyw
2008 թվականի սեպտեմբերին հրատարակված գիտական հոդված
@hy
2008年の論文
@ja
2008年論文
@yue
2008年論文
@zh-hant
2008年論文
@zh-hk
2008年論文
@zh-mo
2008年論文
@zh-tw
2008年论文
@wuu
name
Dynamic removal of replication ...... ng in Saccharomyces cerevisiae
@ast
Dynamic removal of replication ...... ng in Saccharomyces cerevisiae
@en
type
label
Dynamic removal of replication ...... ng in Saccharomyces cerevisiae
@ast
Dynamic removal of replication ...... ng in Saccharomyces cerevisiae
@en
prefLabel
Dynamic removal of replication ...... ng in Saccharomyces cerevisiae
@ast
Dynamic removal of replication ...... ng in Saccharomyces cerevisiae
@en
P2093
P2860
P356
P1476
Dynamic removal of replication ...... ng in Saccharomyces cerevisiae
@en
P2093
Adam S Miller
Jason A Stewart
Judith L Campbell
Robert A Bambara
P2860
P304
31356-31365
P356
10.1074/JBC.M805965200
P407
P577
2008-09-17T00:00:00Z