Transgenic mice carrying large human genomic sequences with expanded CTG repeat mimic closely the DM CTG repeat intergenerational and somatic instability.
about
Comparative genomics and molecular dynamics of DNA repeats in eukaryotesMolecular genetics and genetic testing in myotonic dystrophy type 1.Identification of RTG2 as a modifier gene for CTG*CAG repeat instability in Saccharomyces cerevisiaeMrc1, Tof1 and Csm3 inhibit CAG.CTG repeat instability by at least two mechanisms.Cell membrane integrity in myotonic dystrophy type 1: implications for therapyAbnormal splicing switch of DMD's penultimate exon compromises muscle fibre maintenance in myotonic dystrophy.CTG trinucleotide repeat "big jumps": large expansions, small miceMSH2 ATPase domain mutation affects CTG*CAG repeat instability in transgenic mice.Intracellular Distribution and Nuclear Activity of Antisense Oligonucleotides After Unassisted Uptake in Myoblasts and Differentiated Myotubes In Vitro.Instability of the octarepeat region of the human prion protein gene.Correlation of inter-locus polyglutamine toxicity with CAG•CTG triplet repeat expandability and flanking genomic DNA GC contentMini- and microsatellite expansions: the recombination connection.RNA-protein interactions in unstable microsatellite diseases.Does (CUG)n repeat in DMPK mRNA 'paint' chromosome 19 to suppress distant genes to create the diverse phenotype of myotonic dystrophy?: A new hypothesis of long-range cis autosomal inactivation.Expanded CTG repeat demarcates a boundary for abnormal CpG methylation in myotonic dystrophy patient tissuesTargeting nuclear RNA for in vivo correction of myotonic dystrophyMolecular, physiological, and motor performance defects in DMSXL mice carrying >1,000 CTG repeats from the human DM1 locus.Role of transcript and interplay between transcription and replication in triplet-repeat instability in mammalian cells.CTG repeat instability and size variation timing in DNA repair-deficient mice.The FMR1 gene and fragile X-associated tremor/ataxia syndrome.Microsatellite repeat instability and neurological disease.Non-radioactive detection of trinucleotide repeat size variability.Hijacking of the mismatch repair system to cause CAG expansion and cell death in neurodegenerative disease.Stabilization of expanded (CTG)•(CAG) repeats by antisense oligonucleotides.Sense and Antisense DMPK RNA Foci Accumulate in DM1 Tissues during DevelopmentInstability of (CTG)n•(CAG)n trinucleotide repeats and DNA synthesisAltered replication in human cells promotes DMPK (CTG)(n) · (CAG)(n) repeat instabilityIdentification and characterization of modified antisense oligonucleotides targeting DMPK in mice and nonhuman primates for the treatment of myotonic dystrophy type 1.Repeat instability: mechanisms of dynamic mutations.Myotonic dystrophy CTG expansion affects synaptic vesicle proteins, neurotransmission and mouse behaviour.A low absolute number of expanded transcripts is involved in myotonic dystrophy type 1 manifestation in muscle.Design and analysis of effects of triplet repeat oligonucleotides in cell models for myotonic dystrophyFeatures of trinucleotide repeat instability in vivo.Extrahelical (CAG)/(CTG) triplet repeat elements support proliferating cell nuclear antigen loading and MutLα endonuclease activationOGG1 initiates age-dependent CAG trinucleotide expansion in somatic cellsModelling and inference reveal nonlinear length-dependent suppression of somatic instability for small disease associated alleles in myotonic dystrophy type 1 and Huntington diseaseTriplet-repeat oligonucleotide-mediated reversal of RNA toxicity in myotonic dystrophy.Myotonic dystrophy mouse models: towards rational therapy development.Transcriptionally Repressive Chromatin Remodelling and CpG Methylation in the Presence of Expanded CTG-Repeats at the DM1 Locus.Synaptic protein dysregulation in myotonic dystrophy type 1: Disease neuropathogenesis beyond missplicing
P2860
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P2860
Transgenic mice carrying large human genomic sequences with expanded CTG repeat mimic closely the DM CTG repeat intergenerational and somatic instability.
description
2000 nî lūn-bûn
@nan
2000 թուականի Մայիսին հրատարակուած գիտական յօդուած
@hyw
2000 թվականի մայիսին հրատարակված գիտական հոդված
@hy
2000年の論文
@ja
2000年論文
@yue
2000年論文
@zh-hant
2000年論文
@zh-hk
2000年論文
@zh-mo
2000年論文
@zh-tw
2000年论文
@wuu
name
Transgenic mice carrying large ...... ional and somatic instability.
@ast
Transgenic mice carrying large ...... ional and somatic instability.
@en
type
label
Transgenic mice carrying large ...... ional and somatic instability.
@ast
Transgenic mice carrying large ...... ional and somatic instability.
@en
prefLabel
Transgenic mice carrying large ...... ional and somatic instability.
@ast
Transgenic mice carrying large ...... ional and somatic instability.
@en
P2093
P356
P1476
Transgenic mice carrying large ...... tional and somatic instability
@en
P2093
A S Lia-Baldini
H Hofmann-Radvanyi
P304
P356
10.1093/HMG/9.8.1185
P577
2000-05-01T00:00:00Z