A high-throughput screening method for the determination of aqueous drug solubility using laser nephelometry in microtiter plates.
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Structure-Guided Lead Optimization of Triazolopyrimidine-Ring Substituents Identifies Potent Plasmodium falciparum Dihydroorotate Dehydrogenase Inhibitors with Clinical Candidate PotentialIn vitro assessment of the antimicrobial activity of wound dressings: influence of the test method selected and impact of the pHSynthesis and Evaluation of a 2,11-Cembranoid-Inspired LibraryThermodynamic parameters for salt-induced reversible protein precipitation from automated microscale experiments.Monitoring of HTS compound library quality via a high-resolution image acquisition and processing instrument.Interpreting physicochemical experimental data sets.High-throughput identification of inhibitors of human mitochondrial peptide deformylase.Lead optimization studies of cinnamic amide EP2 antagonistsAntiparasitic Sesquiterpenes from the Cameroonian Spice Scleria striatinux and Preliminary In Vitro and In Silico DMPK Assessment.Development of second generation EP2 antagonists with high selectivitySolubility at the molecular level: development of a critical aggregation concentration (CAC) assay for estimating compound monomer solubility.Analysis of the adaptation capacity of Staphylococcus aureus to commonly used antiseptics by microplate laser nephelometry.Predictive approaches to increase absorption of compounds during lead optimisation.Enone- and chalcone-chloroquinoline hybrid analogues: in silico guided design, synthesis, antiplasmodial activity, in vitro metabolism, and mechanistic studies.Chemiluminescent nitrogen detection (CLND) to measure kinetic aqueous solubility.Structure-activity relationships of a novel pyranopyridine series of Gram-negative bacterial efflux pump inhibitors.Identification of inhibitors that target dual-specificity phosphatase 5 provide new insights into the binding requirements for the two phosphate pocketsHigh-throughput in vitro profiling assays: lessons learnt from experiences at Novartis.In vitro models for processes involved in intestinal absorption.Maximising use of in vitro ADMET tools to predict in vivo bioavailability and safety.Tetrahydro-2-naphthyl and 2-Indanyl Triazolopyrimidines Targeting Plasmodium falciparum Dihydroorotate Dehydrogenase Display Potent and Selective Antimalarial ActivityDiscovery and characterization of carbamothioylacrylamides as EP2 selective antagonists.A novel derivative of the natural agent deguelin for cancer chemoprevention and therapy.Optimization of novel indole-2-carboxamide inhibitors of neurotropic alphavirus replication.Revisiting the SAR of the Antischistosomal Aryl Hydantoin (Ro 13-3978).Aqueous solubility of crystalline and amorphous drugs: Challenges in measurement.Hybrid imidazole (benzimidazole)/pyridine (quinoline) derivatives and evaluation of their anticancer and antimycobacterial activity.Synthesis, structure, antimycobacterial and anticancer evaluation of new pyrrolo-phenanthroline derivatives.Discovery pharmaceutics--challenges and opportunities.Preparation and Evaluation of Potent Pentafluorosulfanyl-Substituted Anti-Tuberculosis Compounds.Determination of drug-like properties of a novel antileishmanial compound: In vitro absorption, distribution, metabolism, and excretion studies.Use of the Biopharmaceutical Classification System in early drug development.Trypanothione reductase high-throughput screening campaign identifies novel classes of inhibitors with antiparasitic activity.Novel selective β1-adrenoceptor antagonists for concomitant cardiovascular and respiratory disease.Bioactive compounds of Shuang-Huang-Lian prescription and an insight into its binding mechanism by β2 -adrenoceptor chromatography coupled with site-directed molecular docking.Overview of drug discovery and development.Linking solubility and permeability assays for maximum throughput and reproducibility.Progress in antischistosomal N,N'-diaryl urea SAR.Vehicle development, pharmacokinetics and toxicity of the anti-invasive agent 4-fluoro-3',4',5'-trimethoxychalcone in rodents.Studies of the precipitation pattern of paclitaxel in intravenous infusions and rat plasma using laser nephelometry.
P2860
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P2860
A high-throughput screening method for the determination of aqueous drug solubility using laser nephelometry in microtiter plates.
description
2000 nî lūn-bûn
@nan
2000 թուականի Ապրիլին հրատարակուած գիտական յօդուած
@hyw
2000 թվականի ապրիլին հրատարակված գիտական հոդված
@hy
2000年の論文
@ja
2000年論文
@yue
2000年論文
@zh-hant
2000年論文
@zh-hk
2000年論文
@zh-mo
2000年論文
@zh-tw
2000年论文
@wuu
name
A high-throughput screening me ...... elometry in microtiter plates.
@ast
A high-throughput screening me ...... elometry in microtiter plates.
@en
type
label
A high-throughput screening me ...... elometry in microtiter plates.
@ast
A high-throughput screening me ...... elometry in microtiter plates.
@en
prefLabel
A high-throughput screening me ...... elometry in microtiter plates.
@ast
A high-throughput screening me ...... elometry in microtiter plates.
@en
P356
P1433
P1476
A high-throughput screening me ...... elometry in microtiter plates.
@en
P2093
P304
P356
10.1021/AC9912247
P407
P577
2000-04-01T00:00:00Z