DNA damage during mitosis in human cells delays the metaphase/anaphase transition via the spindle-assembly checkpoint.
about
CDK5RAP2 is required for spindle checkpoint functionLoss of pRB causes centromere dysfunction and chromosomal instabilityHuman enhancer of invasion-cluster, a coiled-coil protein required for passage through mitosisMaintaining Genome Stability in Defiance of Mitotic DNA DamageDNA damage associated with mitosis and cytokinesis failureBub3-BubR1-dependent sequestration of Cdc20Fizzy at DNA breaks facilitates the correct segregation of broken chromosomesHypersensitivity to DNA damage in antephase as a safeguard for genome stability.DNA topoisomerase II is a determinant of the tensile properties of yeast centromeric chromatin and the tension checkpointA mitotic topoisomerase II checkpoint in budding yeast is required for genome stability but acts independently of Pds1/securin.Kinetochore alignment within the metaphase plate is regulated by centromere stiffness and microtubule depolymerasesDrosophila CENP-A mutations cause a BubR1-dependent early mitotic delay without normal localization of kinetochore componentsA mitotic phosphorylation feedback network connects Cdk1, Plk1, 53BP1, and Chk2 to inactivate the G(2)/M DNA damage checkpointChromosome tips damaged in anaphase inhibit cytokinesisGW8510 increases insulin expression in pancreatic alpha cells through activation of p53 transcriptional activityThe E4F protein is required for mitotic progression during embryonic cell cyclesDNA damage activates the SAC in an ATM/ATR-dependent manner, independently of the kinetochore.Coordinated requirements of human topo II and cohesin for metaphase centromere alignment under Mad2-dependent spindle checkpoint surveillance.Comparative analysis of different laser systems to study cellular responses to DNA damage in mammalian cellsDNA damage-induced cell death is enhanced by progression through mitosisAnalysis of DNA double-strand break response and chromatin structure in mitosis using laser microirradiation.Chk1 and Wee1 kinases coordinate DNA replication, chromosome condensation, and anaphase entry.UV-C irradiation delays mitotic progression by recruiting Mps1 to kinetochoresTopoIIα prevents telomere fragility and formation of ultra thin DNA bridges during mitosis through TRF1-dependent binding to telomeresMitotic catenation is monitored and resolved by a PKCε-regulated pathwayAurora B-mediated localized delays in nuclear envelope formation facilitate inclusion of late-segregating chromosome fragments.Topoisomerase II and histone deacetylase inhibitors delay the G2/M transition by triggering the p38 MAPK checkpoint pathwayCharacteristics of primary and immortalized fibroblast cells derived from the miniature and domestic pigs.RPA phosphorylation facilitates mitotic exit in response to mitotic DNA damage.Ionizing radiation-dependent and independent phosphorylation of the 32-kDa subunit of replication protein A during mitosisSpatially sculpted laser scissors for study of DNA damage and repair.DNA lesions induced by replication stress trigger mitotic aberration and tetraploidy developmentDNA damage-induced mitotic catastrophe is mediated by the Chk1-dependent mitotic exit DNA damage checkpointMerotelic attachments and non-homologous end joining are the basis of chromosomal instability.Generating chromosome instability through the simultaneous deletion of Mad2 and p53.Cdk1 uncouples CtIP-dependent resection and Rad51 filament formation during M-phase double-strand break repairMU2 and HP1a regulate the recognition of double strand breaks in Drosophila melanogaster.DNA damage to a single chromosome end delays anaphase onsetModeling the basal dynamics of p53 system.Canonical non-homologous end joining in mitosis induces genome instability and is suppressed by M-phase-specific phosphorylation of XRCC4p21-Mediated nuclear retention of cyclin B1-Cdk1 in response to genotoxic stress.
P2860
Q24321342-C8A001B0-0A40-4092-B38E-EEE3390D36B6Q24321598-C1023A51-6BF8-4254-86CC-424FFEBB24EAQ24623475-3E35E2A0-CE8E-46CC-94FA-8841D16DECF4Q26738970-8FC94DE1-25C7-42BD-90FC-DE085DD54CF9Q26991874-B23634AD-0F19-449A-A2B5-04692A93C76CQ27309441-0C3A3880-F09D-4BD2-AC92-5D6D63C8327AQ27331358-2A50EE85-92C8-4E72-B273-964621EC7D1FQ27929929-A09B89D2-89EF-43AF-957E-B5703D45A4BFQ27938059-8EC118ED-96A5-4B63-9586-6655CA5981F4Q28275327-B3A7CA3E-A0DE-4BCB-8150-7399A919C296Q28469022-E745B48E-62FF-4A19-8846-15C53E32F81EQ28472643-02BA349D-35E5-40C8-8DCC-DCAFC3E1CE76Q28475293-F0B506F7-86BB-49E1-8DAE-BF3AA34EA32AQ28478710-D6B76F65-66F5-40CA-8537-790ABDF6E048Q28589183-185A9F80-9302-41AF-8542-65A024C445B6Q30443388-79F316FA-7242-4162-B61D-CA807B584F70Q30477159-B9BCF5B2-ACD8-4BAD-B562-CD05AC766409Q30487741-7388EFB3-C5A4-4FB2-B6FD-EFF83C5192F9Q30495277-66D63032-3B9E-4AF0-B6BF-6935D6D9ED23Q30497641-4BC7BA6E-B6B4-4913-BA0E-6C70B861729EQ30510173-9900BB15-030D-4FCD-9C55-9C980F283F30Q30540340-425B6546-E99B-4BFD-8360-EE331C56FA23Q30580233-F0236B82-D61C-4E81-B0DD-1BBD834EB398Q30610125-10DACF4A-E80C-49B2-97E5-AE915885AE13Q30654031-CC240C4D-645D-40F6-9AB8-D7E7DC8FBAD2Q33205671-87CCE4E6-E811-4176-BC55-C8CA73A6E40FQ33286432-C67C5A27-4297-4653-AB4A-3784D705B4B6Q33362855-CDC0E3E8-264D-41C8-AC8D-DF9629558C68Q33492639-D2920689-8804-4879-B1DA-0BA9653E1216Q33515375-336F8AAF-8AC2-4293-B39A-9AC4F6D87EB3Q33526294-20692B4D-4ECF-4C41-8BFA-238B5879C590Q33762022-50ED2A7F-525A-4A37-A707-EC6A18539786Q33884341-7A95E162-30E4-4A61-B61F-4612B99BD826Q33910498-5B38B09D-0163-4814-9E8C-55BBE725A36FQ34011429-F1CAD311-C55A-4A3F-B688-964A253DDCD4Q34038351-4F5AB5D0-1A5A-45E4-B65B-CCF167F78C36Q34044618-E3E06536-339B-4C9F-8DD6-2898E3F0DEBEQ34082945-124F896A-673F-4F99-A5DC-F1D39E79610FQ34104535-20B799A7-531A-4A61-9A3A-C93A9D5A3812Q34325063-AAA36BCC-EDA0-448A-8368-528C3C79C7D2
P2860
DNA damage during mitosis in human cells delays the metaphase/anaphase transition via the spindle-assembly checkpoint.
description
2002 nî lūn-bûn
@nan
2002 թուականի Հոկտեմբերին հրատարակուած գիտական յօդուած
@hyw
2002 թվականի հոտեմբերին հրատարակված գիտական հոդված
@hy
2002年の論文
@ja
2002年論文
@yue
2002年論文
@zh-hant
2002年論文
@zh-hk
2002年論文
@zh-mo
2002年論文
@zh-tw
2002年论文
@wuu
name
DNA damage during mitosis in h ...... e spindle-assembly checkpoint.
@ast
DNA damage during mitosis in h ...... e spindle-assembly checkpoint.
@en
type
label
DNA damage during mitosis in h ...... e spindle-assembly checkpoint.
@ast
DNA damage during mitosis in h ...... e spindle-assembly checkpoint.
@en
prefLabel
DNA damage during mitosis in h ...... e spindle-assembly checkpoint.
@ast
DNA damage during mitosis in h ...... e spindle-assembly checkpoint.
@en
P2093
P1433
P1476
DNA damage during mitosis in h ...... e spindle-assembly checkpoint.
@en
P2093
Alexei Mikhailov
Conly L Rieder
Richard W Cole
P304
P356
10.1016/S0960-9822(02)01226-5
P407
P577
2002-10-01T00:00:00Z