DNA polymerase active site is highly mutable: evolutionary consequences.
about
Structure-guided recombination creates an artificial family of cytochromes P450.POLN, a nuclear PolA family DNA polymerase homologous to the DNA cross-link sensitivity protein Mus308Evidence for the involvement of human DNA polymerase N in the repair of DNA interstrand cross-linksJavaProtein Dossier: a novel web-based data visualization tool for comprehensive analysis of protein structureHuman DNA Polymerase Mutations Allowing Efficient Abasic Site BypassLearning from directed evolution: Thermus aquaticus DNA polymerase mutants with translesion synthesis activityProtein tolerance to random amino acid changeDNA polymerase theta contributes to the generation of C/G mutations during somatic hypermutation of Ig genes.Mechanism of suppression of chromosomal instability by DNA polymerase POLQDNA polymerases engineered by directed evolution to incorporate non-standard nucleotidesThe role of electrostatic interactions on klentaq1 insight for domain separationEnzymatic properties of rat DNA polymerase beta mutants obtained by randomized mutagenesisDistinct function of conserved amino acids in the fingers of Saccharomyces cerevisiae DNA polymerase alpha.Multiple amino acid substitutions allow DNA polymerases to synthesize RNA.Directed evolution of novel polymerase activities: mutation of a DNA polymerase into an efficient RNA polymerase.Purifying selection masks the mutational flexibility of HIV-1 reverse transcriptase.Laboratory-directed protein evolutionHighly tolerated amino acid substitutions increase the fidelity of Escherichia coli DNA polymerase I.Kinetic pathway of pyrophosphorolysis by a retrotransposon reverse transcriptase.Optimization of DNA polymerase mutation rates during bacterial evolution.Frail hypotheses in evolutionary biology.Visualizing high error levels during gene expression in living bacterial cells.Engineering processive DNA polymerases with maximum benefit at minimum costClinical and molecular findings in osteoporosis-pseudoglioma syndrome.Multiple mutations and cancer.Three R's of bacterial evolution: how replication, repair, and recombination frame the origin of species.Shotgun metagenomics indicates novel family A DNA polymerases predominate within marine virioplankton.The biochemistry and fidelity of synthesis by the apicoplast genome replication DNA polymerase Pfprex from the malaria parasite Plasmodium falciparumThe decoupling between genetic structure and metabolic phenotypes in Escherichia coli leads to continuous phenotypic diversity.Template properties of mutagenic cytosine analogues in reverse transcription.Chips and SNPs, bugs and thugs: a molecular sleuthing perspective.The Gly-952 residue of Saccharomyces cerevisiae DNA polymerase alpha is important in discriminating correct deoxyribonucleotides from incorrect ones.Arg660Ser mutation in Thermus aquaticus DNA polymerase I suppresses T-->C transitions: implication of wobble base pair formation at the nucleotide incorporation step.Phylogenetic evidence for horizontal transfer of mutS alleles among naturally occurring Escherichia coli strains.The phage N4 virion RNA polymerase catalytic domain is related to single-subunit RNA polymerases.The Translesion Polymerase ζ Has Roles Dependent on and Independent of the Nuclease MUS81 and the Helicase RECQ4A in DNA Damage Repair in Arabidopsis.DNA polymerase eta undergoes alternative splicing, protects against UV sensitivity and apoptosis, and suppresses Mre11-dependent recombination.Toward a designed genetic system with biochemical function: polymerase synthesis of single and multiple size-expanded DNA base pairsExploring the Chemistry of Genetic Information Storage and Propagation through Polymerase Engineering.Nucleotide specificity of HIV-1 reverse transcriptases with amino acid substitutions affecting Ala-114.
P2860
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P2860
DNA polymerase active site is highly mutable: evolutionary consequences.
description
2000 nî lūn-bûn
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2000 թուականի Մայիսին հրատարակուած գիտական յօդուած
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2000 թվականի մայիսին հրատարակված գիտական հոդված
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2000年の論文
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2000年論文
@yue
2000年論文
@zh-hant
2000年論文
@zh-hk
2000年論文
@zh-mo
2000年論文
@zh-tw
2000年论文
@wuu
name
DNA polymerase active site is highly mutable: evolutionary consequences.
@ast
DNA polymerase active site is highly mutable: evolutionary consequences.
@en
type
label
DNA polymerase active site is highly mutable: evolutionary consequences.
@ast
DNA polymerase active site is highly mutable: evolutionary consequences.
@en
prefLabel
DNA polymerase active site is highly mutable: evolutionary consequences.
@ast
DNA polymerase active site is highly mutable: evolutionary consequences.
@en
P2860
P356
P1476
DNA polymerase active site is highly mutable: evolutionary consequences.
@en
P2093
P2860
P304
P356
10.1073/PNAS.97.10.5095
P407
P577
2000-05-01T00:00:00Z