Copper(II)-induced conformational changes and protease resistance in recombinant and cellular PrP. Effect of protein age and deamidation.
about
Disruption of copper homeostasis due to a mutation of Atp7a delays the onset of prion diseaseThe PrP-like protein Doppel binds copperThe oxidative mechanism of heparin interferes with radical production by glucose and reduces the degree of glycooxidative modifications on human serum albumin.Comparative analysis of the human and chicken prion protein copper binding regions at pH 6.5.Utilizing NMR and EPR spectroscopy to probe the role of copper in prion diseases.Identification of metal-binding proteins in human hepatoma lines by immobilized metal affinity chromatography and mass spectrometry.Cleavage of the amino terminus of the prion protein by reactive oxygen species.Mapping Cu(II) binding sites in prion proteins by diethyl pyrocarbonate modification and matrix-assisted laser desorption ionization-time of flight (MALDI-TOF) mass spectrometric footprinting.High sensitivity detection of protein molecules picked up on a probe of atomic force microscope based on the fluorescence detection by a total internal reflection fluorescence microscope.Effects of spontaneous deamidation on the cytotoxic activity of the Bacillus anthracis protective antigen.Insights into prion protein function from atomistic simulations.Cellular prion protein and NMDA receptor modulation: protecting against excitotoxicity.Immunomodulation for prion and prion-related diseases.The transmissible spongiform encephalopathies: pathogenic mechanisms and strategies for therapeutic intervention.Insect cell-derived cofactors become fully functional after proteinase K and heat treatment for high-fidelity amplification of glycosylphosphatidylinositol-anchored recombinant scrapie and BSE prion proteins.Octarepeat region flexibility impacts prion function, endoproteolysis and disease manifestationCopper alters aggregation behavior of prion protein and induces novel interactions between its N- and C-terminal regions.Recent advances in prion chemotherapeutics.Modulation of proteinase K-resistant prion protein in cells and infectious brain homogenate by redox iron: implications for prion replication and disease pathogenesisCopper and Zinc Interactions with Cellular Prion Proteins Change Solubility of Full-Length Glycosylated Isoforms and Induce the Occurrence of Heterogeneous PhenotypesCopper-induced structural conversion templates prion protein oligomerization and neurotoxicity.Modeling by assembly and molecular dynamics simulations of the low Cu2+ occupancy form of the mammalian prion protein octarepeat region: gaining insight into Cu2+-mediated beta-cleavage.Ligand binding promotes prion protein aggregation--role of the octapeptide repeatsProtein-protein interactions and lens transparency.Functional implications of multistage copper binding to the prion protein.Metal Dyshomeostasis and Their Pathological Role in Prion and Prion-Like Diseases: The Basis for a Nutritional Approach.Metal attenuating therapies in neurodegenerative disease.Role of lipid in forming an infectious prion?Prion disease: a tale of folds and strains.Antioxidant and Metal Chelation-Based Therapies in the Treatment of Prion Disease.Flotillin-1 mediates PrPc endocytosis in the cultured cells during Cu²⁺ stimulation through molecular interaction.Genetic mapping of activity determinants within cellular prion proteins: N-terminal modules in PrPC offset pro-apoptotic activity of the Doppel helix B/B' region.An aggregation-specific enzyme-linked immunosorbent assay: detection of conformational differences between recombinant PrP protein dimers and PrP(Sc) aggregatesCopper induces increased beta-sheet content in the scrapie-susceptible ovine prion protein PrPVRQ compared with the resistant allelic variant PrPARR.Effects of metal binding on solubility and resistance of physiological prions depend on tissues and glycotypes.Binding of recombinant but not endogenous prion protein to DNA causes DNA internalization and expression in mammalian cells.Fragment length influences affinity for Cu2+ and Ni2+ binding to His96 or His111 of the prion protein and spectroscopic evidence for a multiple histidine binding only at low pH.Aggregation of prion protein with insertion mutations is proportional to the number of inserts.Effect of deamidation on folding of ribonuclease A.Eukaryotic CTR copper uptake transporters require two faces of the third transmembrane domain for helix packing, oligomerization, and function.
P2860
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P2860
Copper(II)-induced conformational changes and protease resistance in recombinant and cellular PrP. Effect of protein age and deamidation.
description
2000 nî lūn-bûn
@nan
2000 թուականի Յունիսին հրատարակուած գիտական յօդուած
@hyw
2000 թվականի հունիսին հրատարակված գիտական հոդված
@hy
2000年の論文
@ja
2000年論文
@yue
2000年論文
@zh-hant
2000年論文
@zh-hk
2000年論文
@zh-mo
2000年論文
@zh-tw
2000年论文
@wuu
name
Copper(II)-induced conformatio ...... f protein age and deamidation.
@ast
Copper(II)-induced conformatio ...... f protein age and deamidation.
@en
type
label
Copper(II)-induced conformatio ...... f protein age and deamidation.
@ast
Copper(II)-induced conformatio ...... f protein age and deamidation.
@en
prefLabel
Copper(II)-induced conformatio ...... f protein age and deamidation.
@ast
Copper(II)-induced conformatio ...... f protein age and deamidation.
@en
P2093
P2860
P356
P1476
Copper(II)-induced conformatio ...... f protein age and deamidation.
@en
P2093
Chishti MA
Kretzschmar HA
Westaway D
P2860
P304
19121-19131
P356
10.1074/JBC.275.25.19121
P407
P577
2000-06-01T00:00:00Z