Engineered fibronectin type III domain with a RGDWXE sequence binds with enhanced affinity and specificity to human alphavbeta3 integrin.
about
Structural basis for pure antagonism of integrin αVβ3 by a high-affinity form of fibronectinA simple method for displaying recalcitrant proteins on the surface of bacteriophage lambda.Crystal structure of the complete integrin αVβ3 ectodomain plus an α/β transmembrane fragmentIsolation of monobodies that bind specifically to the SH3 domain of the Fyn tyrosine protein kinase.Picomolar affinity fibronectin domains engineered utilizing loop length diversity, recursive mutagenesis, and loop shuffling.Engineered cystine-knot peptides that bind alpha(v)beta(3) integrin with antibody-like affinities.Engineered cystine knot peptides that bind alphavbeta3, alphavbeta5, and alpha5beta1 integrins with low-nanomolar affinity.The full amino acid repertoire is superior to serine/tyrosine for selection of high affinity immunoglobulin G binders from the fibronectin scaffoldThe use of one-bead one-compound combinatorial library technology to discover high-affinity αvβ3 integrin and cancer targeting arginine-glycine-aspartic acid ligands with a built-in handleAdnectins: engineered target-binding protein therapeuticsCystine-knot peptides engineered with specificities for α(IIb)β(3) or α(IIb)β(3) and α(v)β(3) integrins are potent inhibitors of platelet aggregation.Functional mutation of multiple solvent-exposed loops in the Ecballium elaterium trypsin inhibitor-II cystine knot miniprotein.Anti-idiotypic monobodies derived from a fibronectin scaffold.The α-subunit regulates stability of the metal ion at the ligand-associated metal ion-binding site in β3 integrins.A hypersensitive estrogen receptor alpha mutation that alters dynamic protein interactions(68)Ga-PRGD2 PET/CT in the evaluation of Glioma: a prospective study.A noncanonical function of sortase enables site-specific conjugation of small molecules to lysine residues in proteinsSelection of high-affinity Centyrin FN3 domains from a simple library diversified at a combination of strand and loop positions.Engineering a genetically encoded competitive inhibitor of the KEAP1-NRF2 interaction via structure-based design and phage display.Emerging concepts in engineering extracellular matrix variants for directing cell phenotype.sNASP and ASF1A function through both competitive and compatible modes of histone binding.A comparison of peptide and folate receptor targeting of cancer cells: from single agent to nanoparticle.In vivo gene delivery and expression by bacteriophage lambda vectors.Recombinant adenovirus type 5 vectors that target DC-SIGN, ChemR23 and alpha(v)beta3 integrin efficiently transduce human dendritic cells and enhance presentation of vectored antigensGeneration of surface-bound multicomponent protein gradients.Unexpected multivalent display of proteins by temperature triggered self-assembly of elastin-like polypeptide block copolymers.Generating FN3-Based Affinity Reagents Through Phage Display
P2860
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P2860
Engineered fibronectin type III domain with a RGDWXE sequence binds with enhanced affinity and specificity to human alphavbeta3 integrin.
description
2003 nî lūn-bûn
@nan
2003 թուականի Մարտին հրատարակուած գիտական յօդուած
@hyw
2003 թվականի մարտին հրատարակված գիտական հոդված
@hy
2003年の論文
@ja
2003年論文
@yue
2003年論文
@zh-hant
2003年論文
@zh-hk
2003年論文
@zh-mo
2003年論文
@zh-tw
2003年论文
@wuu
name
Engineered fibronectin type II ...... to human alphavbeta3 integrin.
@ast
Engineered fibronectin type II ...... to human alphavbeta3 integrin.
@en
type
label
Engineered fibronectin type II ...... to human alphavbeta3 integrin.
@ast
Engineered fibronectin type II ...... to human alphavbeta3 integrin.
@en
prefLabel
Engineered fibronectin type II ...... to human alphavbeta3 integrin.
@ast
Engineered fibronectin type II ...... to human alphavbeta3 integrin.
@en
P2093
P1476
Engineered fibronectin type II ...... to human alphavbeta3 integrin.
@en
P2093
Akiko Koide
Johanna Abend
Julie Richards
Michelle Miller
Shohei Koide
P304
P356
10.1016/S0022-2836(03)00082-2
P407
P577
2003-03-01T00:00:00Z