Gene therapy with novel adeno-associated virus vectors substantially diminishes atherosclerosis in a murine model of familial hypercholesterolemia.
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Structure of Adeno-Associated Virus Serotype 8, a Gene Therapy VectorStructural Studies of Adeno-Associated Virus Serotype 8 Capsid Transitions Associated with Endosomal TraffickingIdentification and functional characterization in vivo of a novel splice variant of LDLR in rhesus macaquesGene therapy in a humanized mouse model of familial hypercholesterolemia leads to marked regression of atherosclerosisAAV2/8-mediated correction of OTC deficiency is robust in adult but not neonatal Spf(ash) mice.Sexually dimorphic patterns of episomal rAAV genome persistence in the adult mouse liver and correlation with hepatocellular proliferationLong-term physiologically regulated expression of the low-density lipoprotein receptor in vivo using genomic DNA mini-gene constructsIntensive pharmacological immunosuppression allows for repetitive liver gene transfer with recombinant adenovirus in nonhuman primatesRH10 provides superior transgene expression in mice when compared with natural AAV serotypes for neonatal gene therapy.LDLR-Gene therapy for familial hypercholesterolaemia: problems, progress, and perspectivesEvaluation of adeno-associated viral vectors for liver-directed gene transfer in dogs.Gene transfer of wild-type apoA-I and apoA-I Milano reduce atherosclerosis to a similar extentGene therapy for dyslipidemia: a review of gene replacement and gene inhibition strategiesGene therapy applications of viral vectors.Targeted In Situ Gene Correction of Dysfunctional APOE Alleles to Produce Atheroprotective Plasma ApoE3 Protein.Low-density lipoprotein receptor-related protein 1: a physiological Aβ homeostatic mechanism with multiple therapeutic opportunities.Gene therapy for lipoprotein disorders.Adeno-associated virus serotype 8 gene therapy leads to significant lowering of plasma cholesterol levels in humanized mouse models of homozygous and heterozygous familial hypercholesterolemia.Novel vectors for in vivo gene delivery to vascular tissue.Potential of AAV vectors in the treatment of metabolic disease.AAV-mediated gene therapy for liver diseases: the prime candidate for clinical application?AAV-mediated gene therapy for atherosclerosis.Recent Developments in Gene Therapy for Homozygous Familial Hypercholesterolemia.Niemann-Pick type C2 protein regulates liver cancer progression via modulating ERK1/2 pathway: Clinicopathological correlations and therapeutical implications.RNAi-mediated knockdown of HMG CoA reductase enhances gene expression from physiologically regulated low-density lipoprotein receptor therapeutic vectors in vivo.Long-term inhibition of hepatitis B virus in transgenic mice by double-stranded adeno-associated virus 8-delivered short hairpin RNA.Construction of minicircle DNA vectors capable of correcting familial hypercholesterolemia phenotype in a LDLR-deficient mouse model.Effects of transient immunosuppression on adenoassociated, virus-mediated, liver-directed gene transfer in rhesus macaques and implications for human gene therapy.Efficient AAV1-AAV2 hybrid vector for gene therapy of hemophilia.The incretin hormone GIP is upregulated in patients with atherosclerosis and stabilizes plaques in ApoE-/- mice by blocking monocyte/macrophage activation.Novel Approaches for the Treatment of Familial Hypercholesterolemia: Current Status and Future Challenges
P2860
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P2860
Gene therapy with novel adeno-associated virus vectors substantially diminishes atherosclerosis in a murine model of familial hypercholesterolemia.
description
2004 nî lūn-bûn
@nan
2004 թուականի Յունիսին հրատարակուած գիտական յօդուած
@hyw
2004 թվականի հունիսին հրատարակված գիտական հոդված
@hy
2004年の論文
@ja
2004年論文
@yue
2004年論文
@zh-hant
2004年論文
@zh-hk
2004年論文
@zh-mo
2004年論文
@zh-tw
2004年论文
@wuu
name
Gene therapy with novel adeno- ...... familial hypercholesterolemia.
@ast
Gene therapy with novel adeno- ...... familial hypercholesterolemia.
@en
type
label
Gene therapy with novel adeno- ...... familial hypercholesterolemia.
@ast
Gene therapy with novel adeno- ...... familial hypercholesterolemia.
@en
prefLabel
Gene therapy with novel adeno- ...... familial hypercholesterolemia.
@ast
Gene therapy with novel adeno- ...... familial hypercholesterolemia.
@en
P2093
P921
P356
P1476
Gene therapy with novel adeno- ...... familial hypercholesterolemia.
@en
P2093
Corinna Lebherz
Daniel Rader
Guangping Gao
Jean-Pierre Louboutin
John Millar
P304
P356
10.1002/JGM.554
P577
2004-06-01T00:00:00Z