Loss of Gcn5l2 leads to increased apoptosis and mesodermal defects during mouse development. - Wikidata - wikimedia - TriplyDB

Loss of Gcn5l2 leads to increased apoptosis and mesodermal defects during mouse development.

Loss of Gcn5l2 leads to increased apoptosis and mesodermal defects during mouse development.

http://www.wikidata.org/entity/Q30936148

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Human STAGA complex is a chromatin-acetylating transcription coactivator that interacts with pre-mRNA splicing and DNA damage-binding factors in vivo Glucocorticoid-stimulated preadipocyte differentiation is mediated through acetylation of C/EBPbeta by GCN5 The double-histone-acetyltransferase complex ATAC is essential for mammalian development Human ATAC Is a GCN5/PCAF-containing acetylase complex with a novel NC2-like histone fold module that interacts with the TATA-binding protein Host cell factor and an uncharacterized SANT domain protein are stable components of ATAC, a novel dAda2A/dGcn5-containing histone acetyltransferase complex in Drosophila Chromatin "prepattern" and histone modifiers in a fate choice for liver and pancreas Lessons from genome-wide studies: an integrated definition of the coactivator function of histone acetyl transferases PCAF acetylates {beta}-catenin and improves its stability Multivalent binding of p53 to the STAGA complex mediates coactivator recruitment after UV damage Essential function of p300 acetyltransferase activity in heart, lung and small intestine formation A novel human Ada2 homologue functions with Gcn5 or Brg1 to coactivate transcription Acetylation-mediated transcriptional activation of the ETS protein ER81 by p300, P/CAF, and HER2/Neu Structure and Functional Diversity of GCN5-Related N-Acetyltransferases (GNAT)KATs in cancer: functions and therapies Dimeric structure of p300/CBP associated factor Gcn5p plays an important role in centromere kinetochore function in budding yeast.H2B ubiquitin protease Ubp8 and Sgf11 constitute a discrete functional module within the Saccharomyces cerevisiae SAGA complex.Toxoplasma gondii lysine acetyltransferase GCN5-A functions in the cellular response to alkaline stress and expression of cyst genes Glucagon regulates gluconeogenesis through KAT2B- and WDR5-mediated epigenetic effects The murine SNF5/INI1 chromatin remodeling factor is essential for embryonic development and tumor suppression.MRG15 regulates embryonic development and cell proliferation.Lysine acetyltransferase GCN5b interacts with AP2 factors and is required for Toxoplasma gondii proliferation Histone acetyltransferase MOZ acts as a co-activator of Nrf2-MafK and induces tumour marker gene expression during hepatocarcinogenesis Parathyroid hormone activation of matrix metalloproteinase-13 transcription requires the histone acetyltransferase activity of p300 and PCAF and p300-dependent acetylation of PCAF A novel complex regulates cardiac actin gene expression through interaction of Emb, a class VI POU domain protein, MEF2D, and the histone transacetylase p300 Differential role of p300 and CBP acetyltransferase during myogenesis: p300 acts upstream of MyoD and Myf5 Loss of Gcn5 acetyltransferase activity leads to neural tube closure defects and exencephaly in mouse embryos The histone H3 acetylase dGcn5 is a key player in Drosophila melanogaster metamorphosis.Gcn5 loss-of-function accelerates cerebellar and retinal degeneration in a SCA7 mouse model.Histone acetylation, acetyltransferases, and ataxia--alteration of histone acetylation and chromatin dynamics is implicated in the pathogenesis of polyglutamine-expansion disorders The SAGA continues: expanding the cellular role of a transcriptional co-activator complex.Gcn5 and SAGA regulate shelterin protein turnover and telomere maintenance.A novel histone fold domain-containing protein that replaces TAF6 in Drosophila SAGA is required for SAGA-dependent gene expression.Homozygous disruption of the Tip60 gene causes early embryonic lethality.Reconstitution of enhancer function in paternal pronuclei of one-cell mouse embryos.Chromatin remodeling and transcriptional activation: the cast (in order of appearance).Gcn5 and PCAF regulate PPARγ and Prdm16 expression to facilitate brown adipogenesis N-Myc and GCN5 regulate significantly overlapping transcriptional programs in neural stem cells.Pair of unusual GCN5 histone acetyltransferases and ADA2 homologues in the protozoan parasite Toxoplasma gondii.Chromatin modifiers and remodellers: regulators of cellular differentiation

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P2860

Loss of Gcn5l2 leads to increased apoptosis and mesodermal defects during mouse development.

http://www.wikidata.org/entity/Q30936148

description

2000 nî lūn-bûn

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2000 թուականի Հոկտեմբերին հրատարակուած գիտական յօդուած

@hyw

2000 թվականի հոտեմբերին հրատարակված գիտական հոդված

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2000年の論文

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2000年論文

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2000年論文

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2000年論文

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2000年論文

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2000年論文

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2000年论文

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Loss of Gcn5l2 leads to increa ...... ects during mouse development.

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Loss of Gcn5l2 leads to increa ...... ects during mouse development.

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Loss of Gcn5l2 leads to increa ...... ects during mouse development.

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Loss of Gcn5l2 leads to increa ...... ects during mouse development.

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Loss of Gcn5l2 leads to increa ...... ects during mouse development.

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Nature Genetics

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Loss of Gcn5l2 leads to increa ...... ects during mouse development.

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P2093

Behringer RR

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Edmondson DG

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Evrard YA

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Roth SY

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Wakamiya M

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Xu W

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P2860

A p300/CBP-associated factor that competes with the adenoviral oncoprotein E1A

Mammalian GCN5 and P/CAF acetyltransferases have homologous amino-terminal domains important for recognition of nucleosomal substrates

p53 sites acetylated in vitro by PCAF and p300 are acetylated in vivo in response to DNA damage

Regulation of histone acetyltransferases p300 and PCAF by the bHLH protein twist and adenoviral oncoprotein E1A

Gene dosage-dependent embryonic development and proliferation defects in mice lacking the transcriptional integrator p300

Differential roles of p300 and PCAF acetyltransferases in muscle differentiation

The M-twist gene of Mus is expressed in subsets of mesodermal cells and is closely related to the Xenopus X-twi and the Drosophila twist genes

HNF-3 beta is essential for node and notochord formation in mouse development

DNA damage activates p53 through a phosphorylation-acetylation cascade

Sonic hedgehog, a member of a family of putative signaling molecules, is implicated in the regulation of CNS polarity

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229-232

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10.1038/79973

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11017084

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