The specificity of the FOXL2 c.402C>G somatic mutation: a survey of solid tumors - Wikidata - wikimedia - TriplyDB

The specificity of the FOXL2 c.402C>G somatic mutation: a survey of solid tumors

The specificity of the FOXL2 c.402C>G somatic mutation: a survey of solid tumors

http://www.wikidata.org/entity/Q30943889

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The FOXL2 C134W mutation is characteristic of adult granulosa cell tumors of the ovary.Reinventing diagnostics for personalized therapy in oncology The disparate origins of ovarian cancers: pathogenesis and prevention strategies.Functional exploration of the adult ovarian granulosa cell tumor-associated somatic FOXL2 mutation p.Cys134Trp (c.402C>G).FOXL2 suppresses proliferation, invasion and promotes apoptosis of cervical cancer cells Aromatase is a direct target of FOXL2: C134W in granulosa cell tumors via a single highly conserved binding site in the ovarian specific promoter MicroRNA profiling of ovarian granulosa cell tumours reveals novel diagnostic and prognostic markers.Molecular pathogenesis in granulosa cell tumor is not only due to somatic FOXL2 mutation.The transcriptional targets of mutant FOXL2 in granulosa cell tumours.Molecular analyses of juvenile granulosa cell tumors bearing AKT1 mutations provide insights into tumor biology and therapeutic leads.FOXL2 molecular testing in ovarian neoplasms: diagnostic approach and procedural guidelines.Overexpression of wild-type but not C134W mutant FOXL2 enhances GnRH-induced cell apoptosis by increasing GnRH receptor expression in human granulosa cell tumors.Mutation and loss of expression of ARID1A in uterine low-grade endometrioid carcinoma.Minireview: roles of the forkhead transcription factor FOXL2 in granulosa cell biology and pathology Fine map of the Gct1 spontaneous ovarian granulosa cell tumor locus.Chromosome X loci and spontaneous granulosa cell tumor development in SWR mice: epigenetics and epistasis at work for an ovarian phenotype.Essential but differential role of FOXL2wt and FOXL2C134W in GDF-9 stimulation of follistatin transcription in co-operation with Smad3 in the human granulosa cell line COV434.FOXL2 molecular status in adult granulosa cell tumors of the ovary: A study of primary and metastatic cases A current perspective on the pathological assessment of FOXL2 in adult-type granulosa cell tumours of the ovary.Mutational heterogeneity in non-serous ovarian cancers.Molecularly Defined Adult Granulosa Cell Tumor of the Ovary: The Clinical Phenotype.The changing landscape of gynaecological cancer diagnosis: implications for histopathological practice in the 21st century.Characterization of the inhibitor of kappaB kinase (IKK) complex in granulosa cell tumors of the ovary and granulosa cell tumor-derived cell lines.Adult ovarian granulosa cell tumor transcriptomics: prevalence of FOXL2 target genes misregulation gives insights into the pathogenic mechanism of the p.Cys134Trp somatic mutation.Transcription factor FOXL2 protects granulosa cells from stress and delays cell cycle: role of its regulation by the SIRT1 deacetylase.Differential apoptotic activities of wild-type FOXL2 and the adult-type granulosa cell tumor-associated mutant FOXL2 (C134W).Mutational analysis of FOXL2 p.C134W and expression of bone morphogenetic protein 2 in Japanese patients with granulosa cell tumor of ovary.Pathogenesis and treatment of adult-type granulosa cell tumor of the ovary.FOXL2 posttranslational modifications mediated by GSK3β determine the growth of granulosa cell tumours.The C134W (402 C>G) FOXL2 mutation is absent in ovarian gynandroblastoma: insights into the genesis of an unusual tumour.Nuclear Receptor Profiling of Ovarian Granulosa Cell Tumors Adult Granulosa Cell Tumors of the Ovary: A Retrospective Study of 36 FIGO Stage I Cases with Emphasis on Prognostic Pathohistological Features

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The specificity of the FOXL2 c.402C>G somatic mutation: a survey of solid tumors

http://www.wikidata.org/entity/Q30943889

description

2009 nî lūn-bûn

@nan

2009 թուականի Նոյեմբերին հրատարակուած գիտական յօդուած

@hyw

2009 թվականի նոյեմբերին հրատարակված գիտական հոդված

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2009年の論文

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2009年論文

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2009年論文

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2009年論文

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2009年論文

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2009年論文

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2009年论文

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name

The specificity of the FOXL2 c.402C>G somatic mutation: a survey of solid tumors

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The specificity of the FOXL2 c.402C>G somatic mutation: a survey of solid tumors

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type

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The specificity of the FOXL2 c.402C>G somatic mutation: a survey of solid tumors

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The specificity of the FOXL2 c.402C>G somatic mutation: a survey of solid tumors

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prefLabel

The specificity of the FOXL2 c.402C>G somatic mutation: a survey of solid tumors

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The specificity of the FOXL2 c.402C>G somatic mutation: a survey of solid tumors

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The specificity of the FOXL2 c.402C>G somatic mutation: a survey of solid tumors

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Alireza Heravi-Moussavi

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Bella Gorbatcheva

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C Blake Gilks

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Clara Salamanca

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David G Huntsman

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Janine Senz

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Nataliya Melnyk

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Sarah Maines-Bandiera

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Susanna L Cooke

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P2860

The putative forkhead transcription factor FOXL2 is mutated in blepharophimosis/ptosis/epicanthus inversus syndrome

The murine winged-helix transcription factor Foxl2 is required for granulosa cell differentiation and ovary maintenance

Expanded instrument comparison of amplicon DNA melting analysis for mutation scanning and genotyping.

Potential targets of FOXL2, a transcription factor involved in craniofacial and follicular development, identified by transcriptomics.

Granulosa cell tumor of the ovary: tumor review.

Positive and negative feedback regulates the transcription factor FOXL2 in response to cell stress: evidence for a regulatory imbalance induced by disease-causing mutations.

Differential aggregation and functional impairment induced by polyalanine expansions in FOXL2, a transcription factor involved in cranio-facial and ovarian development.

Establishment and characterization of a steroidogenic human granulosa-like tumor cell line, KGN, that expresses functional follicle-stimulating hormone receptor.

Long-term growth and steroidogenic potential of human granulosa-lutein cells immortalized with SV40 large T antigen.

Identification of 34 novel and 56 known FOXL2 mutations in patients with Blepharophimosis syndrome.

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James D Brenton

Kasmintan A Schrader

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2009-11-24T00:00:00Z

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