The NER proteins XPC and CSB, but not ERCC1, regulate the sensitivity to the novel DNA binder S23906: implications for recognition and repair of antitumor alkylators.
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Protein Recognition in Drug-Induced DNA Alkylation: When the Moonlight Protein GAPDH Meets S23906-1/DNA Minor Groove AdductsAtaxia telangiectasia mutated- and Rad3-related kinase drives both the early and the late DNA-damage response to the monofunctional antitumour alkylator S23906.DNA-Destabilizing Agents as an Alternative Approach for Targeting DNA: Mechanisms of Action and Cellular ConsequencesBRCA2 is needed for both repair and cell cycle arrest in mammalian cells exposed to S23906, an anticancer monofunctional DNA binder.Chronic chemotherapeutic stress promotes evolution of stemness and WNT/beta-catenin signaling in colorectal cancer cells: implications for clinical use of WNT-signaling inhibitors.Dual inhibition of ATR and ATM potentiates the activity of trabectedin and lurbinectedin by perturbing the DNA damage response and homologous recombination repair.
P2860
The NER proteins XPC and CSB, but not ERCC1, regulate the sensitivity to the novel DNA binder S23906: implications for recognition and repair of antitumor alkylators.
description
2010 nî lūn-bûn
@nan
2010 թուականի Ապրիլին հրատարակուած գիտական յօդուած
@hyw
2010 թվականի ապրիլին հրատարակված գիտական հոդված
@hy
2010年の論文
@ja
2010年論文
@yue
2010年論文
@zh-hant
2010年論文
@zh-hk
2010年論文
@zh-mo
2010年論文
@zh-tw
2010年论文
@wuu
name
The NER proteins XPC and CSB, ...... epair of antitumor alkylators.
@ast
The NER proteins XPC and CSB, ...... epair of antitumor alkylators.
@en
type
label
The NER proteins XPC and CSB, ...... epair of antitumor alkylators.
@ast
The NER proteins XPC and CSB, ...... epair of antitumor alkylators.
@en
prefLabel
The NER proteins XPC and CSB, ...... epair of antitumor alkylators.
@ast
The NER proteins XPC and CSB, ...... epair of antitumor alkylators.
@en
P2093
P50
P1476
The NER proteins XPC and CSB, ...... repair of antitumor alkylators
@en
P2093
Aimery de Gramont
Alain Sarasin
Annette K Larsen
Daniele G Soares
João A P Henriques
Karima El Ouadrani
Virginie Poindessous
P304
P356
10.1016/J.BCP.2010.04.012
P407
P577
2010-04-22T00:00:00Z