Acquisition of a specific and potent PTP1B inhibitor from a novel combinatorial library and screening procedure.
about
The role of protein-tyrosine phosphatase 1B in integrin signalingProtein tyrosine phosphatases--from housekeeping enzymes to master regulators of signal transductionSmall molecule tools for functional interrogation of protein tyrosine phosphatasesA novel role for protein tyrosine phosphatase 1B as a positive regulator of neuroinflammation.Crystal structure of PTP1B complexed with a potent and selective bidentate inhibitorCrystal structure of the Yersinia protein-tyrosine phosphatase YopH complexed with a specific small molecule inhibitorCrystal structure of Thermoanaerobacter tengcongensis hypoxanthine-guanine phosphoribosyl transferase L160I mutant--insights into inhibitor designStructural genomics of protein phosphatasesAryl Vinyl Sulfonates and Sulfones as Active Site-Directed and Mechanism-Based Probes for Protein Tyrosine PhosphatasesInsights into the Reaction of Protein-tyrosine Phosphatase 1B: CRYSTAL STRUCTURES FOR TRANSITION STATE ANALOGS OF BOTH CATALYTIC STEPSA Highly Selective and Potent PTP-MEG2 Inhibitor with Therapeutic Potential for Type 2 DiabetesSRC kinase regulation in progressively invasive cancerIdentification of small molecule inhibitors of PTPσ through an integrative virtual and biochemical approachAurintricarboxylic acid blocks in vitro and in vivo activity of YopH, an essential virulent factor of Yersinia pestis, the agent of plague.Inhibitors of Src homology-2 domain containing protein tyrosine phosphatase-2 (Shp2) based on oxindole scaffolds.Identifying potent, selective protein tyrosine phosphatase inhibitors from a library of Au(I) complexes.Targeting PTPs with small molecule inhibitors in cancer treatmentSuggestion of suitable animal models for in vivo studies of protein tyrosine phosphatase 1b (PTP1B) inhibitors using computational approaches.High-resolution dose-response screening using droplet-based microfluidics.Chimeric design, synthesis, and biological assays of a new nonpeptide insulin-mimetic vanadium compound to inhibit protein tyrosine phosphatase 1BA combinatorial strategy for the acquisition of potent and specific protein tyrosine phosphatase inhibitorsDesign and synthesis of nonpeptidic, small molecule inhibitors for the Mycobacterium tuberculosis protein tyrosine phosphatase PtpBUsing small molecules to study big questions in cellular microbiology.Targeting protein tyrosine phosphatases for anticancer drug discovery.Substrate selection influences molecular recognition in a screen for lymphoid tyrosine phosphatase inhibitorsIntegrating virtual and biochemical screening for protein tyrosine phosphatase inhibitor discovery.Double click reaction for the acquisition of a highly potent and selective mPTPB inhibitorPTP1B inhibitors as potential therapeutics in the treatment of type 2 diabetes and obesity.Recent advances in protein tyrosine phosphatase 1B inhibitors.Exploring the Existing Drug Space for Novel pTyr Mimetic and SHP2 InhibitorsSpecific inhibition of sensitized protein tyrosine phosphatase 1B (PTP1B) with a biarsenical probeBicyclic benzofuran and indole-based salicylic acids as protein tyrosine phosphatase inhibitorsGeneration of inhibitor-sensitive protein tyrosine phosphatases via active-site mutations.Targeting the PTPome in human disease.Allele-specific inhibition of divergent protein tyrosine phosphatases with a single small molecule.Increased hypothalamic protein tyrosine phosphatase 1B contributes to leptin resistance with ageComparative Analysis of Protein Tyrosine Phosphatases Regulating Microglial Activation.Protein tyrosine phosphatases as drug targets: strategies and challenges of inhibitor development.Protein tyrosine phosphatase structure-function relationships in regulation and pathogenesis.Covalent inhibition of protein tyrosine phosphatases.
P2860
Q24301273-6BCAFDC8-AA79-42A7-8F9C-EC85E2EA68EDQ24622527-40758D40-2759-4846-A3FF-7A824DE24391Q26852276-A8A608D6-D4B1-4365-949A-32DDB094E600Q27303165-081C1137-6446-48C9-AD0E-EB4897BCCC5CQ27640358-199E3B1A-6A41-4893-8BE0-882A668E9421Q27641444-05A1BFE1-497B-4FA6-A227-09F7FB15062BQ27646914-709BD5D3-EED2-4C02-82A9-67DA03F9E374Q27649211-D9C82372-659E-4D32-941A-D06643EB284CQ27650751-1911998B-CC08-4F31-A3C8-71C471946DECQ27660261-EC675DE5-ED52-4856-A365-479DD380C1AAQ27674611-F4F6C887-147A-4760-A93C-E936FAFF4809Q28484914-AF0DB2BE-E1DF-4243-997E-4A4A42E06962Q28485264-52389085-B7C8-494D-9FF7-21B6443ED4A1Q31151176-736DB025-39C9-455C-90A4-10254907A27CQ33357659-63A05C77-CD7D-4509-9B4A-F1F5D8B34E24Q33514906-ECC59106-423E-41CA-8170-674D7BEC9483Q33554884-9856D55B-7144-469D-8624-1762477D61CCQ34043456-A0662668-E28F-40AB-ACC7-003781E460D4Q34112944-EEA3E0E9-BC6B-4D09-9453-C886F513FBF0Q34170125-A95F9DDA-D4F4-400D-817B-6B4260DFE1BAQ34407569-7DCAF86E-AC62-454A-AAB0-6DD16559EC88Q34437023-08D201D8-AB88-4159-BFC7-1068705282B7Q34782644-1A52E944-0314-492A-994D-C2CD1B6BB972Q34789961-98220C58-1D8A-47AA-B1A3-98FB43255116Q34954874-A9AD8105-FFF5-4000-A28D-DAA1414C0551Q34967191-1E354B03-0877-44D6-8F8F-1686A8C5DB6DQ35052636-D696661A-7D41-4D0B-B877-BF61C677799EQ35056063-5ECFE87F-FAA8-4A0D-AC09-9272421D40BAQ35688217-48430F37-8AD2-47E6-920E-F905B1EA25D1Q35697362-2986A1EC-9D11-497E-A0EB-4D624EAD44F7Q35785858-4D97BAAB-A473-4AE6-97E3-45ABBD0E81D4Q35815528-A5FD8AD3-D20E-45D2-9434-DAE45F8AA1E0Q35945120-553F8A71-BFB2-4E29-8746-608BCD4D9CC6Q36379394-D5606546-E23D-4964-968F-DC193DB64DE2Q36922657-FD4F4B37-924C-4B71-8810-2C19620E9BCCQ37001171-1227D215-C012-453F-9573-965ED0B1511FQ37368903-C9615602-F57B-4EF0-BC5E-009511113978Q37855897-E7ECB611-269B-402E-BDDF-ED3D31C0A6E8Q38017355-487578E8-1636-453C-AAD2-2B707C02280CQ39324501-3A35FA15-F495-494F-A68B-849C92543377
P2860
Acquisition of a specific and potent PTP1B inhibitor from a novel combinatorial library and screening procedure.
description
2001 nî lūn-bûn
@nan
2001 թուականի Հոկտեմբերին հրատարակուած գիտական յօդուած
@hyw
2001 թվականի հոտեմբերին հրատարակված գիտական հոդված
@hy
2001年の論文
@ja
2001年論文
@yue
2001年論文
@zh-hant
2001年論文
@zh-hk
2001年論文
@zh-mo
2001年論文
@zh-tw
2001年论文
@wuu
name
Acquisition of a specific and ...... brary and screening procedure.
@ast
Acquisition of a specific and ...... brary and screening procedure.
@en
type
label
Acquisition of a specific and ...... brary and screening procedure.
@ast
Acquisition of a specific and ...... brary and screening procedure.
@en
prefLabel
Acquisition of a specific and ...... brary and screening procedure.
@ast
Acquisition of a specific and ...... brary and screening procedure.
@en
P2093
P2860
P356
P1476
Acquisition of a specific and ...... brary and screening procedure.
@en
P2093
P2860
P304
47311-47319
P356
10.1074/JBC.M106568200
P407
P577
2001-10-02T00:00:00Z