Structurally modified curcumin analogs inhibit STAT3 phosphorylation and promote apoptosis of human renal cell carcinoma and melanoma cell lines. - Wikidata - wikimedia - TriplyDB

Structurally modified curcumin analogs inhibit STAT3 phosphorylation and promote apoptosis of human renal cell carcinoma and melanoma cell lines.

Structurally modified curcumin analogs inhibit STAT3 phosphorylation and promote apoptosis of human renal cell carcinoma and melanoma cell lines.

http://www.wikidata.org/entity/Q31085777

about

Targeted inhibition of STATs and IRFs as a potential treatment strategy in cardiovascular disease Phytochemicals for the Management of Melanoma Identification of STAT1 and STAT3 specific inhibitors using comparative virtual screening and docking validation STAT inhibitors for cancer therapy.Therapeutic modulators of STAT signalling for human diseases Progress towards the development of SH2 domain inhibitors.Curcumin induces apoptosis through mitochondrial pathway and caspases activation in human melanoma cells.Hirsutinolide Series Inhibit Stat3 Activity, Alter GCN1, MAP1B, Hsp105, G6PD, Vimentin, TrxR1, and Importin α-2 Expression, and Induce Antitumor Effects against Human Glioma.Relevance of Interferon Regulatory Factor-8 Expression in Myeloid-Tumor Interactions.Curcumin ameliorates neuropathic pain by down-regulating spinal IL-1β via suppressing astroglial NALP1 inflammasome and JAK2-STAT3 signalling.Therapeutic targeting of myeloid-derived suppressor cells involves a novel mechanism mediated by clusterin.Myeloid-derived suppressor cell development is regulated by a STAT/IRF-8 axis Pancreatic cancer-associated stellate cells promote differentiation of myeloid-derived suppressor cells in a STAT3-dependent manner.Morphoproteomics and biomedical analytics confirm the mTORC2/Akt pathway as a resistance signature and activated ERK and STAT3 as concomitant prosurvival/antiapoptotic pathways in metastatic renal cell carcinoma (RCC) progressing on rapalogs: pathog Nutritional control of IL-23/Th17-mediated autoimmune disease through HO-1/STAT3 activation Curcuma Contra Cancer? Curcumin and Hodgkin's Lymphoma.Salidroside reduces renal cell carcinoma proliferation by inhibiting JAK2/STAT3 signaling.Use of Polyphenolic Compounds in Dermatologic Oncology.Curcumin: A new candidate for melanoma therapy?Anticancer effect of salidroside on colon cancer through inhibiting JAK2/STAT3 signaling pathway.Signal transducer and activator of transcription proteins: regulators of myeloid-derived suppressor cell-mediated immunosuppression in cancer.STAT3 targeting by polyphenols: Novel therapeutic strategy for melanoma.CRM1 is a cellular target of curcumin: new insights for the myriad of biological effects of an ancient spice.Unleashing the immune response against childhood solid cancers.The potential for targeting the STAT3 pathway as a novel therapy for melanoma.FLLL32, a curcumin analog, ameliorates intestinal injury in necrotizing enterocolitis.Curcumin and Melanoma: From Chemistry to Medicine.The Role of Compounds Derived from Natural Supplement as Anticancer Agents in Renal Cell Carcinoma: A Review.Interferon-α adjuvant therapy decreases the recurrence of early clear cell renal cell carcinoma and improves the prognosis of Chinese patients.PAC exhibits potent anti-colon cancer properties through targeting cyclin D1 and suppressing epithelial-to-mesenchymal transition.L61H46 shows potent efficacy against human pancreatic cancer through inhibiting STAT3 pathway.Co-delivery of curcumin and STAT3 siRNA using deformable cationic liposomes to treat skin cancer.Investigation of the effects of curcumin on serum cytokines in obese individuals: a randomized controlled trial.Genome-Wide Inhibition of Pro-atherogenic Gene Expression by Multi-STAT Targeting Compounds as a Novel Treatment Strategy of CVDs

P2860

Q26750725-6DD49EA7-1132-4955-A784-1ECB0D118026 Q26766708-6DB06C1B-3A94-4496-99EE-C69AD8D47A04 Q28543632-092380B5-23DE-4194-B79F-542370F9B495 Q33644206-5D4012AB-E2C4-4C3C-9257-32C6ED95850A Q33684732-8B25766B-CA22-4515-8FB5-11BE1A044E3C Q34581878-A4E354F4-1F5B-497A-92D8-B9C58D0AD1DE Q35281874-286C0DED-E72B-4EEB-80FD-E13C332EFD5F Q35761986-6BCD42F2-0BBA-4AF6-9184-31FE3D29B8EF Q37062216-D0F54DBE-87FA-4972-B2CA-9CCA27DE3A14 Q37067714-A5E97721-7202-40B6-932D-369B1E12CFBC Q37089543-BD54F93B-C0F7-40A9-9156-F7B6BD866007 Q37200858-E6FFCA0F-A396-4AC8-935A-A0629DC5FF45 Q37203714-033C9801-ECCE-46BC-84F1-07031A6967A7 Q37520310-45B7C895-7EED-4E3A-B9AD-0B569D2F4978 Q37698792-99A6A663-BA50-431D-BC2C-DE0E0949F766 Q38199088-682B1AF2-F606-4F8D-87FD-2732C55B5669 Q38763934-83506497-2992-43F6-9503-416E9CC0E2D1 Q38831160-CC35C245-DF9E-4B81-92BA-E4233F9CE3ED Q38859978-9A76D5E4-0C96-47C8-9164-13C8DC81A86F Q38901701-77F3BD7F-3E72-4DC8-B81C-76A651E54CC4 Q38939956-AFBA8FA9-1DFD-4A47-B791-4649F9B56BB0 Q39023307-FB0B341D-27E3-482F-A11F-6DC359DF2A6E Q39129924-665058C5-EBA0-4B95-BA74-231D40FD9E58 Q39224315-33932B8A-C8D3-4477-85E2-A3DC70C10B03 Q39388206-DEA76160-1E31-4ACF-A059-12B5A2EDA51B Q40156995-CA560816-3C04-450A-AC60-52591F070D60 Q47210956-80E40B00-A21F-45A2-AC29-A066F9C7E47A Q47664030-C799CE7D-2E92-428A-9A3C-A820F503DFBF Q49184688-4B1EC60F-1C7E-4A7C-86AF-258A5C28F14E Q51499892-8DF52535-60A3-4F63-905A-3049B176BA71 Q52614677-0D538C1F-D91C-456B-B117-0FB4979A7495 Q52836414-E502A3F4-3E5C-47CE-86A0-C7D837E8C581 Q55057905-84AF8BB6-F4E9-4FFB-8181-DC60FF4E596A Q57072670-83AEFEA7-C298-4F4B-B892-21A3D34D411C

P2860

Structurally modified curcumin analogs inhibit STAT3 phosphorylation and promote apoptosis of human renal cell carcinoma and melanoma cell lines.

http://www.wikidata.org/entity/Q31085777

description

2012 nî lūn-bûn

@nan

2012 թուականի Օգոստոսին հրատարակուած գիտական յօդուած

@hyw

2012 թվականի օգոստոսին հրատարակված գիտական հոդված

@hy

2012年の論文

@ja

2012年学术文章

@wuu

2012年学术文章

@zh-cn

2012年学术文章

@zh-hans

2012年学术文章

@zh-my

2012年学术文章

@zh-sg

2012年學術文章

@yue

name

Structurally modified curcumin ...... inoma and melanoma cell lines.

@ast

Structurally modified curcumin ...... inoma and melanoma cell lines.

@en

type

label

Structurally modified curcumin ...... inoma and melanoma cell lines.

@ast

Structurally modified curcumin ...... inoma and melanoma cell lines.

@en

prefLabel

Structurally modified curcumin ...... inoma and melanoma cell lines.

@ast

Structurally modified curcumin ...... inoma and melanoma cell lines.

@en

P1433

Q31085777-F5566ACC-65AE-4CE1-A14E-AB5633080D07

P1476

Q31085777-5C228F02-3538-4B27-A106-717B5A314606

P2093

Q31085777-07A04244-3C97-463E-B26F-3968BBB4BAFF

Q31085777-0E3B6209-B005-4008-A8AF-6A9702D641FC

Q31085777-2EFABBF6-C6E6-4697-900D-82D5D8250D63

Q31085777-5062D352-7E4D-41B4-8665-1754B6E74757

Q31085777-527193DF-BB1B-4816-A1BB-1B305B550694

Q31085777-8199390B-1E4C-4659-81C7-EE89E1B0C64A

Q31085777-A224C3FA-0270-4613-B85B-71728E2F58C2

Q31085777-A84935FE-E00F-4BC2-A4EF-84E58631C94C

Q31085777-B677E817-748F-46E1-8970-F86E39C79EA4

Q31085777-E593DD02-B9A0-4BE2-BAC7-A418FAA97ED6

P2860

Q31085777-0AD57B3E-8AD6-4F2A-8250-50EB23F8882D

Q31085777-0E44A273-7A15-4053-98EF-DBDB1481E524

Q31085777-150AADD7-1F86-4ECE-87AD-98EB7BCB6B53

Q31085777-17773F2B-546C-4A5D-A061-DAF29D72F797

Q31085777-19DE3DF6-FAD0-45BB-B44E-2FFADBCC2561

Q31085777-2257A91F-02B4-4A48-8C7C-33DD00481958

Q31085777-2D04DC42-3B8D-4299-B230-7207000DF5C0

Q31085777-3087DE9B-8511-458A-86ED-83089B17DC62

Q31085777-3F5403E4-2CD6-46AD-BD13-EC4ECCACFE6C

Q31085777-4030C841-C244-4491-BB6F-F514D2FAB69E

P304

Q31085777-C1ED0196-005B-4CA3-8ECD-4288C5E4E5C9

P31

Q31085777-ABD2DA83-0C5A-4547-A130-8FAFBD100714

P356

Q31085777-A5293086-F9D0-40A6-93C1-8EEDCC146B6A

P407

Q31085777-BD222CA3-F7E6-4FBE-8139-792D800C86B4

P433

Q31085777-0B192A68-9214-4FB6-B3D3-1BBE8C2650DA

P478

Q31085777-D9070376-BAEB-49C9-B2A8-59A922A2CCFA

P50

Q31085777-6AF42D17-E700-4501-85DC-5CCF6BB1B9C8

P577

Q31085777-04A630FB-53AC-4FA7-A230-D195DB0D2496

P5875

Q31085777-6F714439-5652-4E26-A4AB-CBD36AF7AB60

P698

Q31085777-D02EE4F3-61D1-42FC-979E-A3358463FCC1

P921

Q31085777-21FF4C9F-F36B-49C3-80B7-68941B6E44DB

Q31085777-43f25671-e78d-45fd-84c0-b88e27e0ccb3

Q31085777-B3EFFBDD-33C5-4754-985B-313E4903E00A

P932

Q31085777-57D7C7C2-BFB5-49CF-9542-06486A450B25

P356

JOURNAL.PONE.0040724

P1433

P1476

Structurally modified curcumin ...... inoma and melanoma cell lines.

@en

P2093

Chenglong Li

http://www.w3.org/2001/XMLSchema#string

Eric B Schwartz

http://www.w3.org/2001/XMLSchema#string

Gregory B Lesinski

http://www.w3.org/2001/XMLSchema#string

Gregory S Young

http://www.w3.org/2001/XMLSchema#string

James R Fuchs

http://www.w3.org/2001/XMLSchema#string

Jiayuh Lin

http://www.w3.org/2001/XMLSchema#string

Jonathan P Etter

http://www.w3.org/2001/XMLSchema#string

Lei He

http://www.w3.org/2001/XMLSchema#string

Li Lin

http://www.w3.org/2001/XMLSchema#string

Matthew A Bill

http://www.w3.org/2001/XMLSchema#string

P2860

Regulation of hypoxia-inducible factor 1alpha expression and function by the mammalian target of rapamycin.

The European Medicines Agency review of pazopanib for the treatment of advanced renal cell carcinoma: summary of the scientific assessment of the Committee for Medicinal Products for Human Use

Cancer statistics, 2010

TOR, a central controller of cell growth.

Stat3 mediates myeloid cell-dependent tumor angiogenesis in mice

A semiempirical free energy force field with charge-based desolvation

Identification of the von Hippel-Lindau disease tumor suppressor gene

A novel small molecule inhibits STAT3 phosphorylation and DNA binding activity and exhibits potent growth suppressive activity in human cancer cells.

High-throughput screening fluorescence polarization assay for tumor-specific Hsp90.

Myeloid derived suppressor cells inhibit natural killer cells in patients with hepatocellular carcinoma via the NKp30 receptor.

P304

e40724

http://www.w3.org/2001/XMLSchema#string

P31

scholarly article

P356

10.1371/JOURNAL.PONE.0040724

http://www.w3.org/2001/XMLSchema#string

P407

P433

8

http://www.w3.org/2001/XMLSchema#string

P478

7

http://www.w3.org/2001/XMLSchema#string

P50

Courtney Nicholas

P577

2012-08-10T00:00:00Z

http://www.w3.org/2001/XMLSchema#dateTime

P5875

230686396

http://www.w3.org/2001/XMLSchema#string

P698

22899991

http://www.w3.org/2001/XMLSchema#string

P921

apoptotic process

phosphorylation

P932

3416819

http://www.w3.org/2001/XMLSchema#string