Small molecule inhibitors of the RNA-dependent protein kinase.
about
Suppression of PKR promotes network excitability and enhanced cognition by interferon-γ-mediated disinhibitionWest Nile Virus-Induced Interferon Production Is Mediated by the Double-Stranded RNA-Dependent Protein Kinase PKRDiscovery of Diverse Small-Molecule Inhibitors of Mammalian Sterile20-like Kinase 3 (MST3)Satratoxin G-induced apoptosis in PC-12 neuronal cells is mediated by PKR and caspase independentHepatitis C virus controls interferon production through PKR activationThe potent Cdc7-Dbf4 (DDK) kinase inhibitor XL413 has limited activity in many cancer cell lines and discovery of potential new DDK inhibitor scaffoldsInflammatory Stress on Autophagy in Peripheral Blood Mononuclear Cells from Patients with Alzheimer's Disease during 24 Months of Follow-UpThe oxindole/imidazole derivative C16 reduces in vivo brain PKR activationActivation of double-stranded RNA-activated protein kinase by mild impairment of oxidative metabolism in neuronsInhibition of ATF-3 expression by B-Raf mediates the neuroprotective action of GW5074Interaction of double-stranded RNA-dependent protein kinase (PKR) with the death receptor signaling pathway in amyloid beta (Abeta)-treated cells and in APPSLPS1 knock-in miceListeria monocytogenes induces an interferon-enhanced activation of the integrated stress response that is detrimental for resolution of infection in miceStress granule formation mediates the inhibition of colonic Hsp70 translation by interferon-gamma and tumor necrosis factor-alpha.PKR is activated by cellular dsRNAs during mitosis and acts as a mitotic regulatorActivation of PKR causes amyloid ß-peptide accumulation via de-repression of BACE1 expression.Free mRNA in excess upon polysome dissociation is a scaffold for protein multimerization to form stress granules.Signaling pathways initiated by beta-hydroxy-beta-methylbutyrate to attenuate the depression of protein synthesis in skeletal muscle in response to cachectic stimuli.Hepatitis C virus reveals a novel early control in acute immune response.The double-stranded RNA-dependent protein kinase differentially regulates insulin receptor substrates 1 and 2 in HepG2 cellsThe small molecule ISRIB reverses the effects of eIF2α phosphorylation on translation and stress granule assemblyAttenuation of muscle atrophy in a murine model of cachexia by inhibition of the dsRNA-dependent protein kinaseEffect of branched-chain amino acids on muscle atrophy in cancer cachexia.Direct activation of ribosome-associated double-stranded RNA-dependent protein kinase (PKR) by deoxynivalenol, anisomycin and ricin: a new model for ribotoxic stress response inductionA chemical compound commonly used to inhibit PKR, {8-(imidazol-4-ylmethylene)-6H-azolidino[5,4-g] benzothiazol-7-one}, protects neurons by inhibiting cyclin-dependent kinase.Ethanol promotes thiamine deficiency-induced neuronal death: involvement of double-stranded RNA-activated protein kinase.Stimulators of translation identified during a small molecule screening campaignMicroRNA-122 Inhibits the Production of Inflammatory Cytokines by Targeting the PKR Activator PACT in Human Hepatic Stellate CellsThe double-stranded RNA bluetongue virus induces type I interferon in plasmacytoid dendritic cells via a MYD88-dependent TLR7/8-independent signaling pathway.PKR Transduces MDA5-Dependent Signals for Type I IFN Induction.Duplex RNA-binding enzymes: headliners from neurobiology, virology, and development.Enzyme kinetics and distinct modulation of the protein kinase N family of kinases by lipid activators and small molecule inhibitors.The use of novel selectivity metrics in kinase research.Translational inhibition of colonic epithelial heat shock proteins by IFN-gamma and TNF-alpha in intestinal inflammation.Requirement for protein kinase R in interleukin-1alpha-stimulated effects in cartilage.Movements of HIV-1 genomic RNA-APOBEC3F complexes and PKR reveal cytoplasmic and nuclear PKR defenses and HIV-1 evasion strategies.HIV-1-infected and/or immune-activated macrophages regulate astrocyte CXCL8 production through IL-1beta and TNF-alpha: involvement of mitogen-activated protein kinases and protein kinase R.Interferon-induced RIP1/RIP3-mediated necrosis requires PKR and is licensed by FADD and caspasesRepression of PKR mediates palmitate-induced apoptosis in HepG2 cells through regulation of Bcl-2.eIF2α phosphorylation controls thermal nociception.Involvement of interleukin-1β in the autophagic process of microglia: relevance to Alzheimer's disease
P2860
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P2860
Small molecule inhibitors of the RNA-dependent protein kinase.
description
2003 nî lūn-bûn
@nan
2003 թուականի Օգոստոսին հրատարակուած գիտական յօդուած
@hyw
2003 թվականի օգոստոսին հրատարակված գիտական հոդված
@hy
2003年の論文
@ja
2003年論文
@yue
2003年論文
@zh-hant
2003年論文
@zh-hk
2003年論文
@zh-mo
2003年論文
@zh-tw
2003年论文
@wuu
name
Small molecule inhibitors of the RNA-dependent protein kinase.
@ast
Small molecule inhibitors of the RNA-dependent protein kinase.
@en
type
label
Small molecule inhibitors of the RNA-dependent protein kinase.
@ast
Small molecule inhibitors of the RNA-dependent protein kinase.
@en
prefLabel
Small molecule inhibitors of the RNA-dependent protein kinase.
@ast
Small molecule inhibitors of the RNA-dependent protein kinase.
@en
P2093
P1476
Small molecule inhibitors of the RNA-dependent protein kinase.
@en
P2093
Landon R Whitby
Narasimham V Jammi
Peter A Beal
P356
10.1016/S0006-291X(03)01318-4
P407
P577
2003-08-01T00:00:00Z